The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Effects of intestinal microbiota on anxiety-like behavior
Open accessAbstract
The acquisition of intestinal microbiota in the immediate postnatal period has a defining impact on the development and function of many immune and metabolic systems integral to health and well-being. Recent research has shown that the presence of gut microbiota regulates the set point for hypothalamic-pituitary-adrenal (HPA) axis activity.1 Accordingly, we sought to investigate if there were other changes of brain function such as behavioral alterations in germ free (GF) mice, and if so, to compare these to behavior of mice with normal gut microbiota. Our recent paper showed reduced anxietylike behavior in the elevated plus maze (EPM) in adult GF mice when compared to conventionally reared specific pathogen-free (SPF) mice.2 Here, we present data collected when we next colonized the adult GF mice with SPF feces thereby introducing normal gut microbiota, and then reassessed anxiety-like behavior. Interestingly, the anxiolytic behavioral phenotype observed in GF mice persisted after colonization with SPF intestinal microbiota. These data show that gut-brain interactions are important to CNS development of stress systems and that a critical window may exist after which reconstitution of microbiota and the immune system does not normalize the behavioral phenotype.
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In the citing paper
“Preliminary studies have demonstrated that alterations in the GI microbiota can lead to long-term increased anxiety (69, 115, 116) and altered exploratory behavior in mice (18, 19).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [115]
In the citing paper
“Subsequent microbial colonization reverses these processes.”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [88]
In the citing paper
“Absence of colonization results in differential expression of proteins involved in synaptogenesis [87] and atypical development [88].”
From Gut microbiota changes in children with autism spectrum disorder: a systematic review (2020) · cites this paper as [88]
Citations
Cites
Normal gut microbiota modulates brain development and behavior
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Cited by
Sorted by citations
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460
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Gut/brain axis and the microbiota
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How informative is the mouse for human gut microbiota research?
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Metadata
- Authors
- Neufeld, K.-A. M., Kang, N., Bienenstock, J., & Foster, J. A.
- Affiliations
- McMaster University (CA)
- St. Joseph’s Healthcare Hamilton (CA)
- Corresponding author
- Foster, Jane A.
- Venue
- Communicative & Integrative Biology
- Publisher
- Informa UK Limited
- Published
- 2011-07
- Volume
- 4
- Issue
- 4
- Pages
- 492-494
- ISSN
- 1942-0889 (ISSN-L)
- PMC
- PMC3181531
- OpenAlex
- W2137150469
- Cited by
- 311
- References
- 20
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 21 · 2023: 20 · 2022: 28 · 2021: 37 · 2020: 25 · 2019: 34 · 2018: 24 · 2017: 27 · 2016: 19 · 2015: 26 · 2014: 10 · 2013: 12 · 2012: 4
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Communicative & Integrative Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, anxiety-like behavior, germ-free mice, fecal microbiota transplantation, gut-brain axis, hypothalamic-pituitary-adrenal axis, stress response, central nervous system development
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