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Cited by 77Dermatology and Skin DiseasesReceptor Mechanisms and SignalingPeroxisome Proliferator-Activated Receptors

Sebaceous gland receptors

Open access
Zouboulis, Christos C.·2009·Dermato-Endocrinology
DOI 10.4161/derm.1.2.7804PMC PMC2835895
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Abstract

Receptors are proteins, embedded in a cell or cytoplasmic membrane, to which a mobile signaling molecule may attach. Receptor ligands may be peptides (such as neurotransmitters), hormones, pharmaceutical drugs and/or a toxins, whereas "binding" ordinarily initiates a cellular response. Human sebocytes are biologically and metabolically very active cells and consequently express numerous receptors. Three of four groups of peptide/neurotransmitter receptors, the so-called serpentine receptor group are present (corticotropin-releasing hormone receptors 1 and 2, melanocortin-1 and 5 receptors, mu-opiate receptors, VPAC receptors, cannabinoid receptors 1 and 2, vascular endothelial growth factor receptor and histamine 1 receptor). The single-transmembrane domain receptors are represented by the insulin-like growth factor-I receptor and the third group, which does not possess intrinsic tyrosine kinase activity, by the growth factor receptor. Nuclear receptors expressed in sebocytes are grouped into two major subtypes. From the steroid receptor family, the androgen receptor and the progesterone receptor are expressed. The thyroid receptor family includes the estrogen receptors (alpha and beta isotypes), the retinoic acid receptors (isotypes alpha and gamma) and retinoid X receptors (isotypes alpha, beta, gamma), the vitamin D receptor, the peroxisome proliferator-activated receptors (isotypes alpha, delta and gamma) and the liver X receptors (alpha and beta isotypes). The vanilloid receptor belongs to the transient ion channels and is expressed in differentiating human sebocytes. Further sebocyte receptors, which may influence their function are fibroblast growth factor receptor 2, epidermal growth factor receptor, c-MET, CD14, Toll-like receptor 2, Toll-like receptor 4 and Toll-like receptor 6. Receptor-ligand interactions control sebocyte proliferation, differentiation and lipid synthesis. However, not every ligand that binds to a sebocyte receptor also activates it, such ligands are receptor antagonists and inverse agonists.

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  • LXR receptors have a well-defined role in cellular cholesterol homeostasis and lipid metabolism.

    “The Liver X Receptor (LXR) receptors which have a well-defined role in cellular cholesterol homeostasis and lipid metabolism75,76”

    From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [76]

    The Sebocyte Receptors section (page not available) reports that LXR ligands increase lipogenesis in SZ95 sebocytes and induce lipid-synthesis targets, supporting a role in lipid metabolism. It does not describe a role in cellular cholesterol homeostasis, and its discussion is limited to sebocytes rather than cells generally. (LLM, conf=0.85)

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Authors
Zouboulis, C. C.
Affiliations
Städtisches Klinikum Dessau (DE)
Corresponding author
Zouboulis, Christos C.
ORCID
Zouboulis, Christos C.
Venue
Dermato-Endocrinology
Publisher
Informa UK Limited
Published
2009-03
Volume
1
Issue
2
Pages
77-80
ISSN
  • 1938-1972 (ISSN-L)
  • 1938-1980
DOI
10.4161/derm.1.2.7804
PMC
PMC2835895
OpenAlex
W1978020926
Cited by
77
References
3
Citations by year
2026: 5 · 2025: 6 · 2024: 1 · 2023: 6 · 2022: 8 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 2 · 2014: 7 · 2013: 6 · 2012: 3
FWCI
3.76
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Dermato-Endocrinology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
sebocytes, sebaceous glands, cell surface receptors, serpentine receptors, nuclear receptors, steroid hormone receptors, thyroid hormone receptor, vanilloid receptor, Toll-like receptors, FGFR2, epidermal growth factor receptor, c-Met, CD14, receptor antagonists, inverse agonists, sebocyte differentiation, lipogenesis

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