The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Sebaceous gland lipids
Open accessAbstract
The principal activity of mature sebaceous glands is producing and secreting sebum, which is a complex mixture of lipids. Sebum composition is different among species and this difference is probably due to the function that sebum has to absolve. In human sebum there are unique lipids, such as squalene and wax esters not found anywhere else in the body nor among the epidermal surface lipids. Moreover, they correspond to major components supplying the skin with protection. However, the ultimate role of human sebum, as well the metabolic pathways regulating its composition and secretion rate, are far from a complete understanding. Increased sebum secretion is considered, among all features, the major one involved in the pathophysiology of acne. Along with increased sebum secretion rate, quali- and quantitative modifications of sebum are likely to occur in this pathology. Understanding the factors and mechanisms that regulate sebum production is needed in order to identify new targets that can be addressed to achieve a selective modulation of lipid biosynthesis as a novel therapeutic strategy to correct lipid disregulations in acne and other disorders of the pilosebaceous unit.
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“Due to the rapid degradation of linoleic acid in the sebaceous cells, stearoyl-CoA Δ-6 desaturase is able to convert palmitic acid (C16:0) into sapienic acid (C16:1Δ6).3”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [3]
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In the citing paper
“Furthermore, studies also detected decreased level of vitamin E in acne subjects, which also leads to inflammation and underlines a general importance of lipid peroxidation in the development of acne.3”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [3]
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“The elongation and further desaturation of sapienic acid yields another unique sebaceous gland fatty acid, sebaleic acid (18:2Δ5, 8).3”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [3]
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“Sebum is primarily composed of cell debris and nonpolar (neutral) lipids, namely triglycerides, wax esters, squalene, cholesterol and free fatty acids.3,4”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [3]
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Cites
Schweiger, D., Baufeld, C., Drescher, P., Oltrogge, B., Höpfner, S., Mess, A., Lüttke, J., Rippke, F., Filbry, A. W., & Max, H. (2013) · Skin Pharmacology and Physiology · doi:10.1159/000348473 · Cited by 1,349
Dietary polyunsaturated fatty acids and inflammatory mediator production
James, M. J., Gibson, R. A., & Cleland, L. G. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.343s · Cited by 1,129
Polyunsaturated fatty acids in the food chain in the United States
Kris-Etherton, P., Taylor, D. S., Yu-Poth, S., Huth, P., Moriarty, K., Fishell, V., Hargrove, R. L., Zhao, G., & Etherton, T. D. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.179s · Cited by 1,023
Acne vulgaris: a disease of Western civilization
Cordain, L., Lindeberg, S., Hurtado, M., Hill, K., Eaton, S. B., & Brand-Miller, J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.12.1584 · Cited by 500
Thematic review series: Skin Lipids. Sebaceous gland lipids: friend or foe?
Smith, K. R., & Thiboutot, D. M. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r700015-jlr200 · Cited by 388
Anatomical Variation in the Amount and Composition of Human Skin Surface Lipid
Greene, R. S., Downing, D. T., Pochi, P. E., & Strauss, J. S. (1970) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12280318 · Cited by 303
Essential fatty acids and acne
Downing, D. T., Stewart, M. E., Wertz, P. W., & Strauss, J. S. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70025-x · Cited by 261
Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse
Zheng, Y., Eilertsen, K. J., Ge, L., Zhang, L., Sundberg, J. P., Prouty, S. M., Stenn, K. S., & Parimoo, S. (1999) · Nature Genetics · doi:10.1038/15446 · Cited by 249
Trebble, T. M., Arden, N., Stroud, M. A., Wootton, S. A., Burdge, G. C., Miles, E. A., Ballinger, A., Thompson, R. L., & Calder, P. C. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2003892 · Cited by 230
Sebaceous Gland Secretion is a Major Physiologic Route of Vitamin E Delivery to Skin
Packer, L., Weber, S. U., & Thiele, J. J. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00794.x · Cited by 222
Research works printed but not linked: 4
- Cunliffe WJ, 1989, Acne
- Picardo M, 1991, Photodermatol Photoimmunol Photomed, 8, 105
- Llewellyn A, 1967, Proc Nutr Soc, 26, 11
- MacDonald L, 1967, Br J Dermatol, 79, 119
Cited by
Sorted by citations
Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806
Wearable sensors: modalities, challenges, and prospects
Heikenfeld, J., Jajack, A., Rogers, J., Gutruf, P., Tian, L., Pan, T., Li, R., Khine, M., Kim, J., Wang, J., et al. (2018) · Lab on a Chip · doi:10.1039/c7lc00914c · Cited by 1,434
Schweiger, D., Baufeld, C., Drescher, P., Oltrogge, B., Höpfner, S., Mess, A., Lüttke, J., Rippke, F., Filbry, A. W., & Max, H. (2013) · Skin Pharmacology and Physiology · doi:10.1159/000348473 · Cited by 1,349
Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies
Aggarwal, N., Kitano, S., Puah, G. R. Y., Kittelmann, S., Hwang, I. Y., & Chang, M. W. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00431 · Cited by 571
Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions
Zouboulis, C. C., Jourdan, E., & Picardo, M. (2014) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12298 · Cited by 286
Self-citation
Metadata
- Authors
- Picardo, M., Ottaviani, M., Camera, E., & Mastrofrancesco, A.
- Affiliations
- San Gallicano Hospital (IT)
- Corresponding author
- Picardo, Mauro
- Venue
- Dermato-Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2009-03
- Volume
- 1
- Issue
- 2
- Pages
- 68-71
- ISSN
- 1938-1972 (ISSN-L)
- 1938-1980
- PMC
- PMC2835893
- OpenAlex
- W1987764203
- Cited by
- 368
- References
- 38
- Citations by year
- 2026: 28 · 2025: 39 · 2024: 39 · 2023: 39 · 2022: 27 · 2021: 28 · 2020: 27 · 2019: 17 · 2018: 23 · 2017: 19 · 2016: 19 · 2015: 19 · 2014: 16 · 2013: 12 · 2012: 3
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Dermato-Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- sebaceous glands, sebum, sebum lipids, squalene, wax esters, skin protection, acne, lipogenesis, pilosebaceous unit, lipid dysregulation
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