Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions
Abstract
Hyperseborrhoea has been considered as a major aetiopathogenetic factor of acne. However, changes in sebaceous gland activity not only correlate with seborrhoea but also with alterations in sebum fatty acid composition. Current findings indicate that sebum lipid fractions with proinflammatory properties and inflammatory tissue cascades are associated in the process of the development of acne lesions. The oxidant/antioxidant ratio of the skin surface lipids and alterations of lipid composition are the main players in the induction of acne inflammation. Nutrition may influence the development of seborrhoea, the fractions of sebum lipids and acne. Acne is an inflammatory disease probably triggered, among others, by proinflammatory sebum lipid fractions.
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Acne patients have elevated sebum production.
“In the recent years numerous studies have showed, that in addition to an elevated sebum production, acne patients have a markedly altered sebum composition.24,25”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [25]
Acne patients have a markedly altered sebum composition.
“In the recent years numerous studies have showed, that in addition to an elevated sebum production, acne patients have a markedly altered sebum composition.24,25”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [25]
Sebum composition plays a key role in regulating immune responses against bacteria such as P. acnes.
“These results shed light on how sebum composition plays a key role in regulating immune responses against bacteria, such as P. acnes, proving that sebum lipids not only can regulate macrophage function, but also integrate into disease-specific settings, such as acne.25”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [25]
Sebum lipids not only can regulate macrophage function, but also integrate into disease-specific settings, such as acne.
“These results shed light on how sebum composition plays a key role in regulating immune responses against bacteria, such as P. acnes, proving that sebum lipids not only can regulate macrophage function, but also integrate into disease-specific settings, such as acne.25”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [25]
The leptin-induced changes in sebum lipids are characteristics for acne patients' sebum.
“which altogether are also the characteristics for acne patients' sebum.24,25,44”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [25]
Leptin affects lipogenesis by increasing triglyceride levels, increasing the ratio of monounsaturated or polyunsaturated fatty acids to saturated fatty acids, and decreasing the levels of vitamin E.
“also affects lipogenesis by increasing triglyceride levels, thus increasing the ratio of monounsaturated fatty acids or polyunsaturated fatty acids to saturated fatty acids and by decreasing the levels of vitamin E”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [25]
Leptin induces the expression of inflammatory cytokines such as IL-6 and IL-8 in sebocytes.
“Moreover, we have demonstrated that leptin “the satiety hormone”, besides inducing the expression of inflammatory cytokines such as IL-6 and IL-8 in sebocytes also affects lipogenesis by increasing triglyceride levels”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [25]
Cites
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Pollution and acne: is there a link?
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Sebum lipids influence macrophage polarization and activation
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Self-citationIn vivo study of orange peel fermentation and improvement of androgen overproduction causing acne
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- Authors
- Zouboulis, C. C., Jourdan, E., & Picardo, M.
- Affiliations
- Städtisches Klinikum Dessau (DE)
- Bioderma (France) (FR)
- San Gallicano Hospital (IT)
- Corresponding author
- Zouboulis, C.C.
- Venue
- Journal of the European Academy of Dermatology and Venereology
- Publisher
- Wiley
- Published
- 2013-10-18
- Volume
- 28
- Issue
- 5
- Pages
- 527-532
- ISSN
- 0926-9959 (ISSN-L)
- 1468-3083
- OpenAlex
- W1997764251
- Cited by
- 286
- References
- 4
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 20 · 2023: 27 · 2022: 25 · 2021: 39 · 2020: 26 · 2019: 25 · 2018: 18 · 2017: 23 · 2016: 15 · 2015: 14 · 2014: 12 · 2013: 1
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the European Academy of Dermatology and Venereology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- acne, sebum composition, sebaceous gland activity, skin surface lipids, acne inflammation, nutrition
- MeSH terms
- Acne Vulgaris, Humans, Inflammation, Sebum
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