The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression
Abstract
Several studies linking alterations in differential placental methylation with pregnancy disorders have implicated (de)regulation of the placental epigenome with fetal programming and later-in-life disease. We have previously demonstrated that maternal tobacco use is associated with alterations in promoter methylation of placental CYP1A1 and that these changes are correlated with CYP1A1 gene expression and fetal growth restriction. In this study we sought to expand our analysis of promoter methylation by correlating it to gene expression on a genome-wide scale. Employing side-by-side IlluminaHG-12 gene transcription with Infinium27K methylation arrays, we interrogated correlative changes in placental gene expression and DNA methylation associated with maternal tobacco smoke exposure at an epigenome-wide level and in consideration of signature gene pathways. We observed that the expression of 623 genes and the methylation of 1024 CpG dinucleotides are significantly altered among smokers, with only 38 CpGs showing significant differential methylation (differing by a methylation level of ≥10%). We identified a significant Pearson correlation (≥0.7 or ≤-0.7) between placental transcriptional regulation and differential CpG methylation in only 25 genes among non-smokers but in 438 genes among smokers (18-fold increase, p < 0.0001), with a dominant effect among oxidative stress pathways. Differential methylation at as few as 6 sites was attributed to maternal smoking-mediated birth…
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“Studies have shown that prenatal smoking can cause epigenetic changes in fetal and placental tissues, such as altered DNA methylation and dysregulated miRNA expression (67–69)”
Citations
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Cited by
Sorted by citations
DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
Joubert, B. R., Felix, J. F., Yousefi, P., Bakulski, K. M., Just, A. C., Breton, C., Reese, S. E., Markunas, C. A., Richmond, R. C., Xu, C.-J., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.02.019 · Cited by 886
Joubert, B. R., Håberg, S. E., Nilsen, R. M., Wang, X., Vollset, S. E., Murphy, S. K., Huang, Z., Hoyo, C., Midttun, Ø., Cupul-Uicab, L. A., et al. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1205412 · Cited by 716
Placental DNA hypomethylation in association with particulate air pollution in early life
Janssen, B. G., Godderis, L., Pieters, N., Poels, K., Kiciński, M., Cuypers, A., Fierens, F., Penders, J., Plusquin, M., Gyselaers, W., et al. (2013) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-10-22 · Cited by 222
Braun, T., Challis, J. R., Newnham, J. P., & Sloboda, D. M. (2013) · Endocrine Reviews · doi:10.1210/er.2013-1012 · Cited by 196
Janssen, B. G., Byun, H.-M., Gyselaers, W., Lefebvre, W., Baccarelli, A. A., & Nawrot, T. S. (2015) · Epigenetics · doi:10.1080/15592294.2015.1048412 · Cited by 187
Metadata
- Authors
- Suter, M., Ma, J., Harris, A. S., Patterson, L., Brown, K. A., Shope, C., Showalter, L., Abramovici, A., & Aagaard-Tillery, K. M.
- Venue
- Epigenetics
- Publisher
- Informa UK Limited
- Published
- 2011-11
- Volume
- 6
- Issue
- 11
- Pages
- 1284-1294
- ISSN
- 1559-2294
- 1559-2308
- Cited by
- 243
- References
- 2
- Language
- en
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- Suter, M., Ma, J., Harris, A. S., Patterson, L., Brown, K. A., Shope, C., Showalter, L., Abramovici, A., & Aagaard-Tillery, K. M. (2011). Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression. Epigenetics. https://doi.org/10.4161/epi.6.11.17819
