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Cited by 117Probiotics and Fermented FoodsHIV Research and TreatmentReproductive tract infections research

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Effect of 25 weeks probiotic supplementation on immune function of HIV patients

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Hummelen, Ruben, Changalucha, John, Butamanya, Nicodemus L., Koyama, Tara E., Cook, Adrian, Habbema, J. Dik F., Reid, Gregor·2011·Gut Microbes
DOI 10.4161/gmic.2.2.15787
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Abstract

INTRODUCTION: Studies with a follow-up of < 8 weeks have indicated immune-preserving effects of yogurt probiotic supplementation among HIV patients. To evaluate the impact of 25 weeks use of probiotics, a randomized, double blind, controlled study was undertaken on 65 women who were naïve to anti-retroviral treatment. RESULTS: Ten participants were excluded post-randomization due to non-eligibility. Thirty participants were assigned placebo, of whom 25 completed the study versus 19 of 25 completing the study in the probiotics group (p = 0.5). From baseline to 10 weeks follow-up, the CD4 count declined on average 3 CD4 cells/μl (95% Confidence Interval: -97; 91) with placebo versus an increase of 50 cells/μl (95% CI: -61; 162) with probiotics (p = 0.5). From baseline to 25 weeks, the CD4 count increased with 19 cells/μl (95% CI: -90; 129) in the placebo group versus 46 cells/μl (95% CI: -100; 192) with probiotics (p = 0.8). No differences in immune markers, diarrhea incidence or adverse events were observed. DISCUSSION: Lactobacillus GR-1 and RC-14 may be safely consumed at 2 x 10(9) CFU/day by moderately immune compromised HIV patients but this did not universally preserve immune-function. PATIENTS AND METHODS: Women were randomized to receive oral capsules containing Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 (2 x 10(9) colony forming units) or placebo twice daily for 25 weeks. The CD4 count and immune markers (IgG, IgE, IFNγ and IL-10) were measured at baseline and during follow-up, the occurrence of diarrhea was reported daily.

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Metadata

Authors
Hummelen, R., Changalucha, J., Butamanya, N. L., Koyama, T. E., Cook, A., Habbema, J. D. F., & Reid, G.
Affiliations
Lawson Health Research Institute (CA)
Corresponding author
Hummelen, Ruben
ORCID
Venue
Gut Microbes
Publisher
Informa UK Limited
Published
2011-03-28
Volume
2
Issue
2
Pages
80-85
ISSN
  • 1949-0976 (ISSN-L)
  • 1949-0984
DOI
10.4161/gmic.2.2.15787
OpenAlex
W2112914354
Cited by
117
References
31
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 11 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 12 · 2012: 9
FWCI
16.35
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Gut Microbes (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders
  • Advanced Foods and Materials Network
  • Danone Institute of Canada
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
probiotics, HIV, immune function, CD4 count, Lactobacillus rhamnosus GR-1, Lactobacillus reuteri RC-14, women, immunological markers, diarrhea, untreated HIV patients
MeSH terms
Administration, Oral, Adult, Diet Therapy, Female, Humans, Immunologic Factors, Placebos, HIV Infections, CD4 Lymphocyte Count, Probiotics, Lacticaseibacillus rhamnosus

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