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Cited by 131Probiotics and Fermented FoodsGut microbiota and healthMicrobial Metabolites in Food Biotechnology

Effect of probiotic and synbiotic supplementation on inflammatory markers in health and disease status: A systematic review and meta-analysis of clinical trials

Kazemi, Asma, Soltani, Sepideh, Ghorabi, Sima, Keshtkar, Abbas, Daneshzad, Elnaz, Nasri, Fatemeh, Mazloomi, Seyed Mohammad·2020·Clinical Nutrition
DOI 10.1016/j.clnu.2019.04.004
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Abstract

The current systematic review and meta-analysis investigated the effect of probiotic/synbiotic on a wide range of inflammatory and anti-inflammatory markers in healthy and various disease conditions. PubMed, SCOPUS and Web of Science databases were searched. All clinical trials which investigated the effect of oral administration of probiotic or synbiotic on inflammatory markers (C-reactive protein (CRP), interleukin (IL) 1β, IL-4, IL-6, IL-8, IL-10, IL-12, tumor necrosis factor (TNF) α, interferon (IFN) γ and transforming growth factor (TGF) β) for more than one week with concurrent control groups were included. One-hundred sixty seven publications was analysed. Results were as follows: CRP decreased in healthy, metabolic disorders, inflammatory bowel disease (IBD), arthritis and critically ill condition but not in renal failure. IL-1B: no change in healthy subjects and arthritis. TNF-α: decreased in healthy, fatty liver, IBD and hepatic cirrhosis, no change in diabetes, metabolic syndrome (MS) + PCOS (polycystic ovary syndrome) and arthritis. IL-6: no change in healthy, metabolic disorders and arthritis, increased in cirrhosis and renal failure, decreased in PCOS + MS. IL-10: no change in healthy, IBD and metabolic disorders, increased in arthritis. IL-4, IL-8, IL-12, IFN-g and TGF-b: no change in healthy subjects. In conclusion, probiotic/synbiotic decreased some of the inflammatory markers. The intervention was most effective in CRP and TNF-α reduction in healthy or disease state. Moreover, the intervention decreased inflammation most effectively in the following disease conditions, respectively: IBD, arthritis, fatty liver. PROSPERO REGISTRATION NUMBER: CRD42018088688.

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  • Numerous studies have shown that dietary modification, or treatment with probiotics or synbiotics, has the potential to restore normal insulin function.

    “Numerous studies have shown that dietary modification [168,169,170], or treatment with probiotics or synbiotics, has the potential to restore normal insulin function [57,171].”

    From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [171]

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Authors
Kazemi, A., Soltani, S., Ghorabi, S., Keshtkar, A., Daneshzad, E., Nasri, F., & Mazloomi, S. M.
Affiliations
  • Shiraz University (IR)
  • Iran University of Medical Sciences (IR)
  • Tehran University of Medical Sciences (IR)
  • Shiraz University of Medical Sciences (IR)
Corresponding author
Mazloomi, Seyed Mohammad
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2020-03
Volume
39
Issue
3
Pages
789-819
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2019.04.004
OpenAlex
W2940410648
Cited by
131
References
28
Citations by year
2026: 8 · 2025: 18 · 2024: 17 · 2023: 23 · 2022: 27 · 2021: 23 · 2020: 12 · 2019: 2
FWCI
1.44
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
Shiraz University of Medical Sciences
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
probiotics, synbiotics, inflammatory markers, C-reactive protein, TNF-α, interleukin-6, IL-10, anti-inflammatory activity, inflammatory bowel disease, arthritis, hepatic steatosis, metabolic syndrome, polycystic ovary syndrome, liver cirrhosis, renal failure, critically ill patients
MeSH terms
Health Status, Humans, Inflammation, Dietary Supplements, Probiotics, Synbiotics

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