The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Recovery and purification process development for monoclonal antibody production
Open accessAbstract
Hundreds of therapeutic monoclonal antibodies (mAbs) are currently in development, and many companies have multiple antibodies in their pipelines. Current methodology used in recovery processes for these molecules are reviewed here. Basic unit operations such as harvest, Protein A affinity chromatography, and additional polishing steps are surveyed. Alternative processes such as flocculation, precipitation, and membrane chromatography are discussed. We also cover platform approaches to purification methods development, use of high throughput screening methods, and offer a view on future developments in purification methodology as applied to mAbs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
High-performance tangential flow filtration using charged membranes
van Reis, R., Brake, J. M., Charkoudian, J., Burns, D. B., & Zydney, A. L. (1999) · Journal of Membrane Science · doi:10.1016/s0376-7388(99)00048-4 · Cited by 182
Cited by
Developability Assessment During the Selection of Novel Therapeutic Antibodies
Jarasch, A., Koll, H., Regula, J. T., Bader, M., Papadimitriou, A., & Kettenberger, H. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24430 · Cited by 242
Johnson, J., Law, S. Q. K., Shojaee, M., Hall, A. S., Bhuiyan, S., Lim, M. B. L., Silva, A., Kong, K. J. W., Schoppet, M., Blyth, C., et al. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12332 · Cited by 188
Patel, B. A., Gospodarek, A., Larkin, M., Kenrick, S. A., Haverick, M. A., Tugcu, N., Brower, M. A., & Richardson, D. D. (2018) · mAbs · doi:10.1080/19420862.2018.1505178 · Cited by 52
Dada, O. O., Zhao, Y., Jaya, N., & Salas-Solano, O. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03405 · Cited by 20
Wang, C., van Haperen, R., Gutiérrez-Álvarez, J., Li, W., Okba, N. M. A., Albulescu, I., Widjaja, I., van Dieren, B., Fernandez-Delgado, R., Sola, I., et al. (2020) · doi:10.1101/2020.10.20.346916 · Cited by 15
Metadata
- Authors
- Liu, H. F., Ma, J., Winter, C., & Bayer, R.
- Venue
- mAbs
- Publisher
- Informa UK Limited
- Published
- 2010-09
- Volume
- 2
- Issue
- 5
- Pages
- 480-499
- ISSN
- 1942-0862 (ISSN-L)
- 1942-0870
- OpenAlex
- W2010948143
- Cited by
- 561
- References
- 1
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Recovery and purification process development for monoclonal antibody production. https://app.cochat.ai/papers/10.4161/mabs.2.5.12645
- The paper
- Liu, H. F., Ma, J., Winter, C., & Bayer, R. (2010). Recovery and purification process development for monoclonal antibody production. mAbs. https://doi.org/10.4161/mabs.2.5.12645
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
