Developability Assessment During the Selection of Novel Therapeutic Antibodies

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Challenges in the Development of High Protein Concentration Formulations

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Recovery and purification process development for monoclonal antibody production

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Glycosylation of Recombinant Antibody Therapeutics

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Identification of multiple sources of charge heterogeneity in a recombinant antibody

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Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding

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Hydrophobic interaction chromatography of proteins

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Biophysical Properties of Human Antibody Variable Domains

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Molecular Mechanisms of Ion-Specific Effects on Proteins

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The Degradation of Polysorbates 20 and 80 and its Potential Impact on the Stability of Biotherapeutics

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Rational Design of Stable Lyophilized Protein Formulations: Theory and Practice

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Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequential enzymatic digestion.

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The Influence of Charge Distribution on Self-Association and Viscosity Behavior of Monoclonal Antibody Solutions

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In Vivo Deamidation Characterization of Monoclonal Antibody by LC/MS/MS

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In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

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Forced Degradation of Therapeutic Proteins

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Disrupting the hydrophobic patches at the antibody variable/constant domain interface: improved in vivo folding and physical characterization of an engineered scFv fragment

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A strategy for risk mitigation of antibodies with fast clearance

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Therapeutic antibodies: Market considerations, disease targets and bioprocessing

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Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

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Methionine, tryptophan, and histidine oxidation in a model protein, PTH: Mechanisms and stabilization

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Assessment of Net Charge and Protein–Protein Interactions of Different Monoclonal Antibodies

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A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior

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Isomerization of an Aspartic Acid Residue in the Complementarity-Determining Regions of a Recombinant Antibody to Human IgE: Identification and Effect on Binding Affinity

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Reversal of the Hofmeister Series: Specific Ion Effects on Peptides

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Modulation of hydrophobic interactions by proximally immobilized ions

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Prediction of aggregation prone regions of therapeutic proteins

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High throughput thermostability screening of monoclonal antibody formulations

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Viscosity Behavior of High-Concentration Monoclonal Antibody Solutions: Correlation with Interaction Parameter and Electroviscous Effects

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Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain

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Production of Monoclonal Antibodies

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Extending Serum Half-life of Albumin by Engineering Neonatal Fc Receptor (FcRn) Binding

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Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences

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Assessment of chemical modifications of sites in the CDRs of recombinant antibodies

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Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-Cell Responses In Vitro

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Enrichment and Analysis of Nonenzymatically Glycated Peptides: Boronate Affinity Chromatography Coupled with Electron-Transfer Dissociation Mass Spectrometry

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Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions

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Monoclonal Antibody Self-Association, Cluster Formation, and Rheology at High Concentrations

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Antibody humanization methods – a review and update

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High-throughput dynamic light scattering method for measuring viscosity of concentrated protein solutions

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Impact of variable domain glycosylation on antibody clearance: an LC/MS characterization.

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The therapeutic antibodies market to 2008

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High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy

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Deamidation of Asparagine Residues: Direct Hydrolysis versus Succinimide-Mediated Deamidation Mechanisms

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Separation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications

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Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface in dilute salt solutions

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Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

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Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties

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Effect of Ions on Agitation- and Temperature-Induced Aggregation Reactions of Antibodies

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Phase Separation of an IgG1 Antibody Solution under a Low Ionic Strength Condition

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Aspartate Isomerization in the Complementarity-Determining Regions of Two Closely Related Monoclonal Antibodies

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Human antibody Fc deamidation in vivo

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Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies

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Rational design of stable protein formulations : theory and practice

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Glycation during storage and administration of monoclonal antibody formulations

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Developability studies before initiation of process development

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Unveiling a Glycation Hot Spot in a Recombinant Humanized Monoclonal Antibody

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Accumulation of Succinimide in a Recombinant Monoclonal Antibody in Mildly Acidic Buffers Under Elevated Temperatures

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Effects of Ionic Strength and Sugars on the Aggregation Propensity of Monoclonal Antibodies: Influence of Colloidal and Conformational Stabilities

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Isomerization of a Single Aspartyl Residue of Anti-Epidermal Growth Factor Receptor Immunoglobulin γ2 Antibody Highlights the Role Avidity Plays in Antibody Activity

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Concomitant Raman spectroscopy and dynamic light scattering for characterization of therapeutic proteins at high concentrations

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Characterization and Comparison of Disulfide Linkages and Scrambling Patterns in Therapeutic Monoclonal Antibodies: Using LC-MS with Electron Transfer Dissociation

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Kinetics and Thermodynamics of Dimer Formation and Dissociation for a Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor

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High‐Throughput Assessment of Thermal and Colloidal Stability Parameters for Monoclonal Antibody Formulations

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Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions

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An Interactive Web Site Providing Major Histocompatibility Ligand Predictions: Application to HIV Research

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Position Effects of Variable Region Carbohydrate on the Affinity and In Vivo Behavior of an Anti-(1→6) Dextran Antibody

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On the role of salt type and concentration on the stability behavior of a monoclonal antibody solution

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Characterization of Site-Specific Glycation During Process Development of a Human Therapeutic Monoclonal Antibody

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Characterization of the Degradation Products of a Color-Changed Monoclonal Antibody: Tryptophan-Derived Chromophores

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Toward aggregation-resistant antibodies by design

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Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody

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Therapeutic Monoclonal Antibodies

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Rates and impact of human antibody glycation in vivo

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Immunogenicity screening in protein drug development

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SVMHC: a server for prediction of MHC-binding peptides

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Replacing Antibodies: Engineering New Binding Proteins

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Stabilizing mechanisms in commercial albumin preparations: octanoate and N-acetyl-l-tryptophanate protect human serum albumin against heat and oxidative stress

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Controlling glycation of recombinant antibody in fed‐batch cell cultures

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