The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Intrinsic and acquired resistance mechanisms in enterococcus
Open accessAbstract
Enterococci have the potential for resistance to virtually all clinically useful antibiotics. Their emergence as important nosocomial pathogens has coincided with increased expression of antimicrobial resistance by members of the genus. The mechanisms underlying antibiotic resistance in enterococci may be intrinsic to the species or acquired through mutation of intrinsic genes or horizontal exchange of genetic material encoding resistance determinants. This paper reviews the antibiotic resistance mechanisms in Enterococcus faecium and Enterococcus faecalis and discusses treatment options.
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“Furthermore, the presence of this bifunctional enzyme accounts for most of high-level gentamicin resistance detected in enterococci (including in vancomycin-resistant strains) and methicillin-resistant S. aureus worldwide (13).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [13]
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Kohanski, M. A., Dwyer, D. J., Hayete, B., Lawrence, C. A., & Collins, J. J. (2007) · Cell · doi:10.1016/j.cell.2007.06.049 · Cited by 2,982
How antibiotics kill bacteria: from targets to networks
Kohanski, M. A., Dwyer, D. J., & Collins, J. J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2333 · Cited by 2,377
The life and times of the Enterococcus
Murray, B. E. (1990) · Clinical Microbiology Reviews · doi:10.1128/cmr.3.1.46 · Cited by 1,887
Baddour, L. M., Wilson, W. R., Bayer, A. S., Fowler, V. G., Bolger, A. F., Levison, M. E., Ferrieri, P., Gerber, M. A., Tani, L. Y., Gewitz, M. H., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.165564 · Cited by 1,707
Genetic Analysis of a High-Level Vancomycin-Resistant Isolate of Staphylococcus aureus
Weigel, L. M., Clewell, D. B., Gill, S. R., Clark, N. C., McDougal, L. K., Flannagan, S. E., Kolonay, J. F., Shetty, J., Killgore, G., & Tenover, F. C. (2003) · Science · doi:10.1126/science.1090956 · Cited by 909
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Genetics and mechanisms of glycopeptide resistance in enterococci
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Penicillin-binding proteins and β-lactam resistance
Zapun, A., Contreras‐Martel, C., & Vernet, T. (2008) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2007.00095.x · Cited by 690
Correlation of Daptomycin Bactericidal Activity and Membrane Depolarization in Staphylococcus aureus
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- 10.1179/joc.2008.18.1.27 · DOI
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Mechanisms of Antibiotic Resistance
Munita, J. M., & Arias, C. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0016-2015 · Cited by 2,782
Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators
Singer, A. C., Shaw, H., Rhodes, V., & Hart, A. J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01728 · Cited by 895
Cong, Y., Yang, S., & Rao, X. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2019.10.005 · Cited by 571
Selleck, E. M., Tyne, D. V., & Gilmore, M. S. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0053-2018 · Cited by 521
Mechanisms of antibiotic resistance
Munita, J. M., & Arias, C. A. (2016) · Virulence Mechanisms of Bacterial Pathogens · doi:10.1128/9781555819286.ch17 · Cited by 421
Metadata
- Authors
- Hollenbeck, B. L., & Rice, L. B.
- Affiliations
- Brown University (US)
- Corresponding author
- Rice, Louis B.
- Venue
- Virulence
- Publisher
- Informa UK Limited
- Published
- 2012-08-15
- Volume
- 3
- Issue
- 5
- Pages
- 421-569
- ISSN
- 2150-5594 (ISSN-L)
- 2150-5608
- PMC
- PMC3485979
- OpenAlex
- W2084266616
- Semantic Scholar
- b2c50fe60fe2e1bec43d7eace3a0b0d59c75b2e7
- Cited by
- 795
- References
- 147
- Citations by year
- 2026: 66 · 2025: 55 · 2024: 87 · 2023: 67 · 2022: 80 · 2021: 84 · 2020: 66 · 2019: 59 · 2018: 61 · 2017: 46 · 2016: 48 · 2015: 28 · 2014: 27 · 2013: 20 · 2012: 1
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Virulence (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Enterococcus, antibiotic resistance, intrinsic resistance, acquired resistance, Enterococcus faecium, Enterococcus faecalis, nosocomial pathogens, horizontal gene transfer, resistance determinants, antibiotic resistance mechanisms, treatment options
- MeSH terms
- Anti-Bacterial Agents, Cross Infection, Humans, Enterococcus faecalis, Gram-Positive Bacterial Infections, Enterococcus faecium, Drug Resistance, Bacterial
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