Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Annual Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007

Hidron, Alicia I.; Edwards, Jonathan R.; Patel, Jean; Horan, Teresa C.; Sievert, Dawn M.; Pollock, Daniel A.; Fridkin, Scott K.; National Healthcare Safety Network Team and Participating National Healthcare Safety Network Facilities

doi:10.1086/591861

Cited by 3,724Infection Control in HealthcareAntibiotic Resistance in BacteriaNosocomial Infections in ICU

Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Annual Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007

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Hidron, Alicia I., Edwards, Jonathan R., Patel, Jean, Horan, Teresa C., Sievert, Dawn M., Pollock, Daniel A., Fridkin, Scott K., National Healthcare Safety Network Team and Participating National Healthcare Safety Network Facilities·2008·Infection Control & Hospital Epidemiology

DOI 10.1086/591861PMC PMC6857725

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Abstract

Objective.: To describe the frequency of selected antimicrobial resistance patterns among pathogens causing device-associated and procedure-associated healthcare-associated infections (HAIs) reported by hospitals in the National Healthcare Safety Network (NHSN). Methods.: Data are included on HAIs (ie, central line-associated bloodstream infections, catheter-associated urinary tract infections, ventilator-associated pneumonia, and surgical site infections) reported to the Patient Safety Component of the NHSN between January 2006 and October 2007. The results of antimicrobial susceptibility testing of up to 3 pathogenic isolates per HAI by a hospital were evaluated to define antimicrobial-resistance in the pathogenic isolates. The pooled mean proportions of pathogenic isolates interpreted as resistant to selected antimicrobial agents were calculated by type of HAI and overall. The incidence rates of specific device-associated infections were calculated for selected antimicrobial-resistant pathogens according to type of patient care area; the variability in the reported rates is described. Results.: Overall, 463 hospitals reported 1 or more HAIs: 412 (89%) were general acute care hospitals, and 309 (67%) had 200-1,000 beds. There were 28,502 HAIs reported among 25,384 patients. The 10 most common pathogens (accounting for 84% of any HAIs) were coagulase-negative staphylococci (15%), Staphylococcus aureus (15%), Enterococcus species (12%), Candida species (11%), Escherichia coli (10%), Pseudomonas aeruginosa (8%), Klebsiella pneumoniae (6%), Enterobacter species (5%), Acinetobacter baumannii (3%), and Klebsiella oxytoca (2%). The pooled mean proportion of pathogenic isolates resistant to antimicrobial agents varied significantly across types of HAI for some pathogen-antimicrobial combinations. As many as 16% of all HAIs were associated with the following multidrug-resistant pathogens: methicillin-resistant S. aureus (8% of HAIs), vancomycin-resistant Enterococcus faecium (4%), carbapenem-resistant P. aeruginosa (2%), extended-spectrum cephalosporin-resistant K. pneumoniae (1%), extended-spectrum cephalosporin-resistant E. coli (0.5%), and carbapenem-resistant A. baumannii, K. pneumoniae, K. oxytoca, and E. coli (0.5%). Nationwide, the majority of units reported no HAIs due to these antimicrobial-resistant pathogens.

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Invasive fungal infections and fungal sepsis in the intensive care unit are increasing and are associated with considerable morbidity and mortality.
“Invasive fungal infections (IFI) and fungal sepsis in the intensive care unit (ICU) are increasing and are associated with considerable morbidity and mortality.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [2]
In the intensive care unit, invasive fungal infections are predominantly caused by Candida species.
“In this setting, IFI are predominantly caused by Candida species.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [2]
Candidemia is currently the fourth most common health care-associated bloodstream infection.
“Currently, candidemia represents the fourth most common health care-associated blood stream infection.[1][2][3]”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [2]

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National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2003, issued August 2003
System, A. R. F. T. N. (2003) · American Journal of Infection Control · doi:10.1016/j.ajic.2003.09.002 · Cited by 2,923 · see citing works
The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee
Vincent, J. (1995) · JAMA · doi:10.1001/jama.274.8.639 · Cited by 2,381 · see citing works
National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004
System, A. R. F. T. N. (2004) · American Journal of Infection Control · doi:10.1016/j.ajic.2004.10.001 · Cited by 2,354 · see citing works
The Prevalence of Nosocomial Infection in Intensive Care Units in Europe
Vincent, J. (1995) · JAMA · doi:10.1001/jama.1995.03530080055041 · Cited by 1,646 · see citing works
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(1999) · American Journal of Infection Control · doi:10.1016/s0196-6553(99)70031-3 · Cited by 899 · see citing works
Intercontinental emergence of Escherichia coli clone O25:H4-ST131 producing CTX-M-15
Nicolas-Chanoine, M.-H., Blanco, J., Leflon‐Guibout, V., Demarty, R., Alonso, M. P., Caniça, M., Park, Y. J., Lavigne, J., Pitout, J. D. D., & Johnson, J. R. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm464 · Cited by 815 · see citing works
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Klevens, R. M., Edwards, J. R., Tenover, F. C., McDonald, L. C., Horan, T., Gaynes, R. P., & System, N. N. I. S. (2006) · Clinical Infectious Diseases · doi:10.1086/499367 · Cited by 551 · see citing works
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Fridkin, S. K., Steward, C. D., Edwards, J. R., Pryor, E. R., McGowan, J. E., Archibald, L. K., Gaynes, R. P., & Tenover, F. C. (1999) · Clinical Infectious Diseases · doi:10.1086/520193 · Cited by 486 · see citing works
Self-citation
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Bradford, P. A., Bratu, S., Urban, C. M., Visalli, M., Mariano, N., Landman, D., Rahal, J. J., Brooks, S., Cebular, S., & Quale, J. M. (2004) · Clinical Infectious Diseases · doi:10.1086/421495 · Cited by 485 · see citing works
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Chambers, H. F. “. (2005) · New England Journal of Medicine · doi:10.1056/nejme058023 · Cited by 422 · see citing works
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Lockhart, S. R., Abramson, M. A., Beekmann, S. E., Gallagher, G., Riedel, S. F., Diekema, D. J., Quinn, J. P., & Doern, G. V. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.01284-07 · Cited by 396 · see citing works
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Edwards, J. R., Peterson, K. D., Andrus, M. L., Tolson, J. S., Goulding, J. S., Dudeck, M. A., Mincey, R. B., Pollock, D. A., & Horan, T. C. (2007) · American Journal of Infection Control · doi:10.1016/j.ajic.2007.04.001 · Cited by 388 · see citing works
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Pfaller, M. A., Jones, R. N., & Beach, M. L. (1999) · Clinical Infectious Diseases · doi:10.1086/598640 · Cited by 312 · see citing works
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Huang, S. S., Yokoe, D. S., Hinrichsen, V. L., Spurchise, L. S., Datta, R., Miroshnik, I. L., & Platt, R. G. (2006) · Clinical Infectious Diseases · doi:10.1086/507636 · Cited by 286 · see citing works
Emerging resistance among bacterial pathogens in the intensive care unit – a European and North American Surveillance study (2000–2002)
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First Report of the Emergence of CTX-M-Type Extended-Spectrum β-Lactamases (ESBLs) as the Predominant ESBL Isolated in a U.S. Health Care System
Lewis, J. S., Herrera, M., Wickes, B. L., PATTERSON, J. E., & Jorgensen, J. H. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00576-07 · Cited by 228 · see citing works
Assessment of pathogen occurrences and resistance profiles among infected patients in the intensive care unit: report from the SENTRY Antimicrobial Surveillance Program (North America, 2001)
Streit, J. M., Jones, R. N., Sader, H. S., et al. (2004) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2003.12.019 · Cited by 192 · see citing works
Temporal Changes in Prevalence of Antimicrobial Resistance in 23 U.S. Hospitals
Fridkin, S. K., Hill, H. A., Volkova, N. V., et al. (2002) · Emerging infectious diseases · doi:10.3201/eid0807.010427 · Cited by 134 · see citing works
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Richards, C. L., Emori, T. G., Edwards, J. R., Fridkin, S. K., Tolson, J. S., & Gaynes, R. P. (2001) · American Journal of Infection Control · doi:10.1067/mic.2001.118408 · Cited by 96 · see citing works
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Weiner, L. M., Fridkin, S. K., Torres, Z. A., Avery, L., Coffin, N., Dudeck, M. A., Edwards, J. R., Jernigan, J. A., Konnor, R. Y., Soe, M. M., et al. (2016) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6509e1 · Cited by 72 · see citing works
Self-citation
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Chea, N., Bulens, S. N., Kongphet-Tran, T., Lynfield, R., Shaw, K. M., Vagnone, P. S., Kainer, M. A., Muleta, D. B., Wilson, L. E., Vaeth, E., et al. (2015) · Emerging infectious diseases · doi:10.3201/eid2109.150198 · Cited by 67 · see citing works
Frequency of isolation of pathogens from bloodstream, nosocomial pneumonia, skin and soft tissue, and urinary tract infections occurring in European patients.
Fluit, A. C., Schmitz, F.-J., & Verhoef, J. (2001) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-001-8078-8 · Cited by 21 · see citing works

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Research works printed but not linked: 2

[1]Hidron AI, Edwards JR, Patel J, Antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007 (published correction appears in Infect Control Hosp Epidemiol 2009;30:107). Infect Control Hosp Epidemiol 2008; 29: 996– 1011. 18947320
[10]Clinical and Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing: 24th informational supplement. Wayne, PA: CLSI; 2014: M100– S24.

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Burnham, J. P., Olsen, M. A., Stwalley, D., Kwon, J. H., Babcock, H. M., & Kollef, M. H. (2018) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofy026 · Cited by 90 · see citing works
The Empirical Combination of Vancomycin and a -Lactam for Staphylococcal Bacteremia
McConeghy, K. W., Bleasdale, S. C., & Rodvold, K. A. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit560 · Cited by 90 · see citing works
Toward repurposing ciclopirox as an antibiotic against drug-resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae
Carlson-Banning, K. M., Chou, A., Liu, Z., Hamill, R. J., Song, Y., & Zechiedrich, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069646 · Cited by 73 · see citing works
The Transcription Factor Homolog CTF1 Regulates β-Oxidation in Candida albicans
Ramírez, M. A., & Lorenz, M. C. (2009) · Eukaryotic Cell · doi:10.1128/ec.00206-09 · Cited by 67 · see citing works
Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species
Schell, W. A., Jones, A. M., Borroto-Esoda, K., & Alexander, B. D. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01102-17 · Cited by 66 · see citing works
Automatic Digital Analysis of Chromogenic Media for Vancomycin-Resistant-Enterococcus Screens Using Copan WASPLab
Faron, M. L., Buchan, B. W., Coon, C., Liebregts, T., van Bree, A., Jansz, A. R., Soucy, G., Korver, J., & Ledeboer, N. A. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.01040-16 · Cited by 63 · see citing works
Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting
Lepak, A., & Andes, D. (2011) · Critical Care Clinics · doi:10.1016/j.ccc.2010.11.001 · Cited by 62 · see citing works
Changing epidemiology of candidemia in a medical center in middle Taiwan
Hii, I.-M., Chang, H.-L., Lin, L.-C., Lee, Y.-L., Liu, Y.-M., Liu, C.-E., Chen, C.-H., Cheng, Y.-R., & Chang, C.-Y. (2015) · Journal of Microbiology, Immunology and Infection · doi:10.1016/j.jmii.2013.08.017 · Cited by 56 · see citing works
Rat Indwelling Urinary Catheter Model of Candida albicans Biofilm Infection
Nett, J. E., Brooks, E. G., Cabezas-Olcoz, J., Sanchez, H., Zarnowski, R., Marchillo, K., & Andes, D. R. (2014) · Infection and Immunity · doi:10.1128/iai.02284-14 · Cited by 58 · see citing works
Candidemia surveillance in Iowa: emergence of echinocandin resistance
Matsumoto, E., Boyken, L., Tendolkar, S., McDanel, J., Castanheira, M., Pfaller, M., & Diekema, D. (2014) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2014.02.016 · Cited by 50 · see citing works
The antimicrobial activity of lapachol and its thiosemicarbazone and semicarbazone derivatives
Souza, M. A., Johann, S., Lima, L. A. R. D. S., Campos, F. F., Mendes, I. C., Beraldo, H., Souza-Fagundes, E. M. D., Cisalpino, P. S., Rosa, C. A., Alves, T. M. D. A., et al. (2013) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762013000300013 · Cited by 49 · see citing works
Fungal infections in the ICU
Zilberberg, M. D., & Shorr, A. F. (2009) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2009.04.008 · Cited by 42 · see citing works
Potential Role of Lysine Acetylation in Antibiotic Resistance of Escherichia coli
Fang, Z., Lai, F., Cao, K., Zhang, Z., Cao, L., Liu, S., Duan, Y., Yin, X., Ge, R., He, Q.-Y., et al. (2022) · mSystems · doi:10.1128/msystems.00649-22 · Cited by 40 · see citing works
Inhibition of ergosterol synthesis in Candida albicans by novel eugenol tosylate congeners targeting sterol 14α-demethylase (CYP51) enzyme
Lone, S. A., Khan, S., & Ahmad, A. (2020) · Archives of Microbiology · doi:10.1007/s00203-019-01781-2 · Cited by 32 · see citing works
Broadly reactive human CD4 + T cells against Enterobacteriaceae are found in the naïve repertoire and are clonally expanded in the memory repertoire
Cassotta, A., Goldstein, J. D., Durini, G., Jarrossay, D., Baggi Menozzi, F., Venditti, M., Russo, A., Falcone, M., Lanzavecchia, A., Gagliardi, M. C., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202048630 · Cited by 23 · see citing works
Study to Reduce Infection Prior to Elective Cesarean Deliveries (STRIPES): a randomized clinical trial of chlorhexidine
Stone, J., Bianco, A., Monro, J., Overybey, J. R., Cadet, J., Choi, K. H., Pena, J., Robles, B. N., Mella, M. T., Matthews, K. C., et al. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.05.021 · Cited by 18 · see citing works
Exploring the antimicrobial potential of lactobacilli against early-stage and mature biofilms of Staphylococcus aureus and Pseudomonas aeruginosa
Singh, N., Gulhane, R. D., Singh, A., Goel, M., Udelal, P. P., Sangwan, V., Sihag, M. K., Goel, G., Panwar, H., & Puniya, A. K. (2025) · Frontiers in Chemistry · doi:10.3389/fchem.2025.1425666 · Cited by 9 · see citing works
Flow cytometry-based method to detect persisters in Candida albicans
Chang, W., Zhang, M., Li, Y., & Lou, H. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00255-15 · Cited by 7 · see citing works
The structure of KPN03535 (gi|152972051), a novel putative lipoprotein fromKlebsiella pneumoniae, reveals an OB-fold
Das, D., Kozbial, P., Han, G. W., Carlton, D., Jaroszewski, L., Abdubek, P., Astakhova, T., Axelrod, H. L., Bakolitsa, C., Chen, C., et al. (2010) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309109018168 · Cited by 2 · see citing works

Authors: Hidron, A. I., Edwards, J. R., Patel, J., Horan, T. C., Sievert, D. M., Pollock, D. A., Fridkin, S. K., & National Healthcare Safety Network Team and Participating National Healthcare Safety Network Facilities
Affiliations: Centers for Disease Control and Prevention (US)
Corresponding author: Sievert, Dawn M.
ORCID: Edwards, Jonathan R.
Patel, Jean
Horan, Teresa C.
Pollock, Daniel A.
Fridkin, Scott K.
Venue: Infection Control & Hospital Epidemiology
Publisher: Cambridge University Press (CUP)
Published: 2008-11
Volume: 29
Issue: 11
Pages: 996-1011
ISSN: 0899-823X (ISSN-L)
1559-6834
DOI: 10.1086/591861
PMC: PMC6857725
OpenAlex: W2087865186
Cited by: 3,724
References: 36
Citations by year: 2026: 22 · 2025: 49 · 2024: 132 · 2023: 154 · 2022: 182 · 2021: 241 · 2020: 295 · 2019: 324 · 2018: 273 · 2017: 325 · 2016: 288 · 2015: 329 · 2014: 318 · 2013: 247 · 2012: 173
FWCI: 79.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.cambridge.org/core/terms (unspecified, 2253 d)
Locations: Infection Control and Hospital Epidemiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Keywords: nosocomial infections, antimicrobial resistance, device-related infection, central line-associated bloodstream infection, catheter-associated urinary tract infection, ventilator-associated pneumonia, surgical site infection, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, carbapenem-resistant Pseudomonas aeruginosa, multidrug-resistant pathogens, antimicrobial susceptibility testing, National Healthcare Safety Network, hospital infection surveillance
MeSH terms: Anti-Infective Agents, Electronic Data Processing, Bacteria, Bacterial Infections, Centers for Disease Control and Prevention, U.S., Cross Infection, Fungi, Hospitals, Humans, Mycoses, United States, Drug Resistance, Bacterial, Drug Resistance, Multiple, Bacterial, Pneumonia, Ventilator-Associated, Catheter-Related Infections

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