The Surprising Efficiency of Artemisia annua Powder Capsules
Abstract
The administration of powdered leaves of Artemisia annua, used as preventive treatment of malaria attack, was evaluated in 25 patients, most of them children, and all of them were operated for orthopaedic disorder. The duration of the treatment was 36 hours in 11 patients and 60 hours in 14 patients. The average parasitemia was reduced from 432 parasites/ml to 165 parasites/ml, i.e. 62% improvement, without significant difference according to the duration of the treatment. The efficacy was similar whatever the age and the weight of the patient. These results were obtained with a very low amount of powder (400 to 500 mg per day), and with very low quantity of artemisinin (0.4 to 0.5 mg per day). It is concluded that the Artemisia annua powder is apparently more effective than the tea preparation, but more costly and maybe not routinely available. The tea preparation, inexpensive and available everywhere, is still the best method for prevention and treatment of malaria on a large scale and should be preferred in the poorest countries.
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Given that many diseases have responded to treatments using A. annua tea infusions or other forms of directly using the plant, obtaining ever increasing levels of artemisinin may not be as critically needed as previously considered.
“Given that many of the diseases, e.g. malaria, schistosomiasis, leishmania etc., that have responded to treatments using A. annua tea infusions (Munyangi et al. 2018, 2019) or other forms of directly using the plant, e.g. encapsulated powdered leaves (Onimus et al. 2013; Mesa et al. 2017) or compressed leaf tablets (Daddy et al. 2017), obtaining ever increasing levels of artemisinin may not be as”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Onimus et al. 2013
Cites
Ferreira, J., Luthria, D. L., Sasaki, T., & Heyerick, A. (2010) · Molecules · doi:10.3390/molecules15053135 · Cited by 532 · see citing works
Weathers, P. J., Arsenault, P. R., Covello, P. S., McMickle, A., Teoh, K. H., & Reed, D. W. (2010) · Phytochemistry Reviews · doi:10.1007/s11101-010-9166-0 · Cited by 202 · see citing works
Bottius, E., Guanzirolli, A., Trape, J.-F., Rogier, C., Konate, L., & Druilhe, P. (1996) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(96)90463-0 · Cited by 190 · see citing works
Mueller, M. S., Balagizi, I. K., Hirt, H. M., & Wemakor, E. (2000) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00289-0 · Cited by 172 · see citing works
Terpenes Arrest Parasite Development and Inhibit Biosynthesis of Isoprenoids inPlasmodium falciparum
Goulart, H. R., Kimura, E. A., Peres, V. J., Couto, A. S., Duarte, F. A. A., & Katzin, A. M. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.7.2502-2509.2004 · Cited by 162 · see citing works
RÄTH, K., Taxis, K., WALZ, G., Gleiter, C. H., Li, S.-M., & Heide, L. E. (2004) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2004.70.128 · Cited by 144 · see citing works
Dried Whole Plant Artemisia annua as an Antimalarial Therapy
Elfawal, M. A., Towler, M. J., Reich, N. G., Golenbock, D. T., Weathers, P. J., & Rich, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052746 · Cited by 128 · see citing works
de Magalhães, P. M., Dupont, I. E., Hendrickx, A., Joly, A., Raas, T., Dessy, S., Sergent, T., & Schneider, Y. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.02.195 · Cited by 98 · see citing works
Fractionation and characterization of biologically-active polysaccharides from Artemisia tripartita
Xie, G., Schepetkin, I. A., Siemsen, D. W., Kirpotina, L. N., Wiley, J. A., & Quinn, M. T. (2008) · Phytochemistry · doi:10.1016/j.phytochem.2008.01.009 · Cited by 94 · see citing works
Willcox, M. L., Burton, S., Oyweka, R., Namyalo, R., Challand, S., & Lindsey, K. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-84 · Cited by 46 · see citing works
Ogwang, P. E. (2011) · Journal of Pharmaceutical Research International · doi:10.9734/bjpr/2011/392 · Cited by 30 · see citing works
Silva, L. F. R. E., de Magalhães, P. M., Costa, M. R. F., Alecrim, M. D. G. C., Chaves, F. C. M., Hidalgo, A. D. F., Pohlit, A. M., & Vieira, P. P. (2012) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762012000700004 · Cited by 24 · see citing works
[Studies on the antimalarial action of gelatin capsule of Artemisia annua].
Yd, W., Qz, Z., & Js, W. (1992) · PubMed · Cited by 19 · see citing works
Kodippili, K., Ratnasooriya, W. D., Premakumara, G. A. S., et al. (2011) · International Journal of Green Pharmacy · doi:10.22377/ijgp.v5i4.213 · Cited by 9 · see citing works
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Daddy, N. B., Kalisya, L. M., Bagire, P. G., Watt, R. L., Towler, M. J., & Weathers, P. J. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.04.006 · Cited by 79 · see citing works
Wani, K. I., Choudhary, S., Zehra, A., Naeem, M., Weathers, P., & Aftab, T. (2021) · Planta · doi:10.1007/s00425-021-03676-3 · Cited by 74 · see citing works
Towler, M. J., & Weathers, P. J. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.01.007 · Cited by 51 · see citing works
Mesa, L. E., Vasquez, D., Lutgen, P., Vélez, I. D., Restrepo, A. M., Ortiz, I., & Robledo, S. M. (2017) · Revista da Sociedade Brasileira de Medicina Tropical · doi:10.1590/0037-8682-0457-2016 · Cited by 39 · see citing works
- Authors
- Onimus, M.
- Corresponding author
- Onimus, Michel
- Venue
- Medicinal & Aromatic Plants
- Publisher
- OMICS Publishing Group
- Published
- 2013
- Volume
- 02
- Issue
- 03
- ISSN
- 2167-0412 (ISSN-L)
- OpenAlex
- W2142064383
- Cited by
- 25
- References
- 14
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicinal & Aromatic Plants (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Ethnobotanical and Medicinal Plants Studies
- Keywords
- Artemisia annua, artemisinin, malaria, malaria prevention, parasitemia reduction, herbal tea preparation, children
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