The DOI matches its Crossref record; 209 of the 209 references it cites were found in a registry or an index.
BMP signaling in mesenchymal stem cell differentiation and bone formation
Open accessAbstract
Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily and have diverse functions during development and organogenesis. BMPs play a major role in skeletal development and bone formation, and disruptions in BMP signaling cause a variety of skeletal and extraskeletal anomalies. Several knockout models have provided insight into the mechanisms responsible for these phenotypes. Proper bone formation requires the differentiation of osteoblasts from mesenchymal stem cell (MSC) precursors, a process mediated in part by BMP signaling. Multiple BMPs, including BMP2, BMP6, BMP7 and BMP9, promote osteoblastic differentiation of MSCs both in vitro and in vivo. BMP9 is one of the most osteogenic BMPs, yet it is a poorly characterized member of the BMP family. Several studies demonstrate that the mechanisms controlling BMP9-mediated osteogenesis differ from other osteogenic BMPs, but little is known about these specific mechanisms. Several pathways critical to BMP9-mediated osteogenesis are also important in the differentiation of other cell lineages, including adipocytes and chondrocytes. BMP9 has also demonstrated translational promise in spinal fusion and bone fracture repair. This review will summarize our current knowledge of BMP-mediated osteogenesis, with a focus on BMP9, by presenting recently completed work which may help us to further elucidate these pathways.
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1 retracted
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Yoon, J.-Y., Kim, T.-S., Ahn, J.-H., Yoon, J.-U., Kim, H.-J., & Kim, E.-J. (2019) · Journal of Dental Anesthesia and Pain Medicine · doi:10.17245/jdapm.2019.19.2.91 · Cited by 12
Hyperthyroidism-driven bone loss depends on BMP receptor Bmpr1a expression in osteoblasts
Lademann, F., Rijntjes, E., Köhrle, J., Tsourdi, E., Hofbauer, L. C., & Rauner, M. (2024) · Communications Biology · doi:10.1038/s42003-024-06227-0 · Cited by 8
Metadata
- Authors
- Beederman, M., Lamplot, J. D., Nan, G., Wang, J., Liu, X., Yin, L., Li, R., Shui, W., Zhang, H., Kim, S. H., Zhang, W., Zhang, J., Kong, Y., Denduluri, S., Rogers, M. R., Pratt, A., Haydon, R. C., Luu, H. H., Angeles, J., Shi, L. L., & He, T.-C.
- Venue
- Journal of Biomedical Science and Engineering
- Publisher
- Scientific Research Publishing, Inc.
- Published
- 2013
- Volume
- 06
- Issue
- 08
- Pages
- 32-52
- ISSN
- 1937-6871 (ISSN-L)
- 1937-688X
- OpenAlex
- W1968755117
- Cited by
- 318
- References
- 209
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- diamond
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- The paper
- Beederman, M., Lamplot, J. D., Nan, G., Wang, J., Liu, X., Yin, L., Li, R., Shui, W., Zhang, H., Kim, S. H., Zhang, W., Zhang, J., Kong, Y., Denduluri, S., Rogers, M. R., Pratt, A., Haydon, R. C., Luu, H. H., Angeles, J., . . . He, T.-C. (2013). BMP signaling in mesenchymal stem cell differentiation and bone formation. Journal of Biomedical Science and Engineering. https://doi.org/10.4236/jbise.2013.68a1004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
