Highly Efficient Rinse-Off/Leave-On Scalp Care Treatments to Reduce Moderate to Severe Dandruff
Open accessAbstract
Background/Aim: Dandruff is a common scalp problem associated with flaky and inflamed skin. In this study, we investigated the efficacy of a shampoo containing piroctone olamine and climbazole and the combination of this shampoo with a scalp tonic containing piroctone olamine and licochalcone A, derived from Glycyrrhiza inflata root extract, to reduce dandruff. Study Design/Methods: After conditioning, 102 subjects (♂ 56 and 46 ♀) with moderate to very strong dandruff affection underwent a randomized half head study for 4 weeks. The volunteers’ heads were washed regularly either with a placebo or the anti-dandruff shampoo, followed by the anti-dandruff tonic application or no treatment. In a 2-week post-treatment phase, subjects only applied placebo shampoo. Every two weeks, trained experts assessed dandruff affection based on a scale of 1 to 6. At study start and after every 2 weeks, cytokine concentrations and anti-fungal activity of test products were determined in scalp wash-ups by enzyme-linked immunosorbant assays or a Malassezia colony-forming assay, respectively. Results: Results of expert grading and anti-fungal activity revealed a significant reduction in dandruff affection and Malassezia colony-forming units after treatment with the anti-dandruff shampoo or its combination with the tonic. Dandruff affection even remained reduced in the post-treatment phase when levels of Malassezia colony-forming units had returned to baseline. Cytokine analyses proved a significant decrease in pro-inflammatory dandruff markers after treatment with both anti-dandruff products. For the shampoo/tonic combination, a superior reduction of one scalp inflammatory marker was determined even after the post-treatment phase. Conclusion: Both the rinse-off shampoo as well as its combination with the leave-on tonic excellently alleviated dandruff and its associated micro-inflammation. Both treatments showed anti-fungal activity. The superior benefit, exerted by the combination, is primarily based on the known anti-inflammatory effect of licochalcone A and the improved scalp substantivity of the leave-on application.
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The combination of piroctone, olamine, and licochalcone A significantly reduced Malassezia colony-forming units after treatment with the anti-dandruff shampoo.
“Moreover, the anti-fungal activity of test products was detected, revealing a significant reduction of Malassezia colony-forming units after treatment with the anti-dandruff shampoo.”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [89]
The benefit of the combination of piroctone, olamine, and licochalcone A was primarily based on the anti-inflammatory effect of licochalcone A.
“The benefit exerted by the combination was primarily based on the known anti-inflammatory effect of licochalcone A [89].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [89]
In a clinical trial of 102 subjects with moderate to very strong dandruff, a combination of piroctone, olamine, and licochalcone A significantly decreased pro-inflammatory dandruff markers after treatment.
“In this study, a cytokine analysis was performed, and the results proved a significant decrease in pro-inflammatory dandruff markers after treatment with the tested products.”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [89]
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Cites
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“Regarding human skin, licochalcone A has been associated with anti-inflammatory effects in vitro [10,11] and in vivo [11,12].”
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Method
Flagged first, then by citations
5 of the 25 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
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Cited by
Sorted by citations
Cerulli, A., Masullo, M., Montoro, P., & Piacente, S. (2022) · Cosmetics · doi:10.3390/cosmetics9010007 · Cited by 83 · see citing works
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“Various natural product extracts have anti-dandruff activities, such as Camellia sinensis, Rosmarinus officinalis, Glycyrrhiza glabra, Glycyrrhiza inflata, Mentha piperita, Thymus vulgaris, Zingiber officinalis, Sesamum indicum, and Ipomoea aquatica (Borda & Wikramanayake, 2015; Chhavi et al., 2011; Schweiger et al.,…”
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- Authors
- Schweiger, D., Rippke, F., Drescher, P., Braren, S., Lüttke, J., Filbry, A., & Max, H.
- Affiliations
- Beiersdorf (Germany) (DE)
- Corresponding author
- Schweiger, Dorothea
- Venue
- Journal of Cosmetics, Dermatological Sciences and Applications
- Publisher
- Scientific Research Publishing, Inc.
- Published
- 2013
- Volume
- 03
- Issue
- 01
- Pages
- 46-55
- ISSN
- 2161-4105 (ISSN-L)
- 2161-4512
- OpenAlex
- W2061195436
- Cited by
- 5
- References
- 25
- Citations by year
- 2025: 1 · 2022: 2 · 2020: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Cosmetics Dermatological Sciences and Applications (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Epidemiology › Nail Diseases and Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Keywords
- dandruff, anti-dandruff shampoo, piroctone olamine, climbazole, licochalcone A, Malassezia, antifungal activity, scalp inflammation, cytokines, substantivity
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