Anti-inflammatory efficacy of Licochalcone A: Correlation of clinical potency and in vitro effects
Abstract
Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-controlled clinical trials to assess the anti-irritative efficacy of cosmetic formulations containing LicA in a post-shaving skin irritation model and on UV-induced erythema formation. The clinical trials were accompanied by a series of in vitro experiments to characterize anti-inflammatory properties of LicA on several dermatologically relevant cell types. Topical LicA causes a highly significant reduction in erythema relative to the vehicle control in both the shave- and UV-induced erythema tests, demonstrating the anti-irritative properties of LicA. Furthermore, LicA is a potent inhibitor of pro-inflammatory in vitro responses, including N-formyl-MET-LEU-PHE (fMLP)- or zymosan-induced oxidative burst of granulocytes, UVB-induced PGE(2) release by keratinocytes, lipopolysaccharide (LPS)-induced PGE(2) release by adult dermal fibroblasts, fMLP-induced LTB(4) release by granulocytes, and LPS-induced IL-6/TNF-alpha secretion by monocyte-derived dendritic cells. The reported data suggest therapeutic skin care benefits from LicA when applied to sensitive or irritated skin.
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A formulation with licochalcone A causes a highly noteworthy reduction in UV-induced erythema tests, resulting in powerful inhibition of pro-inflammatory in vitro reactions, including UV-B-induced PGE2 release by keratinocytes.
“The formulation caused a highly noteworthy reduction in UV-induced erythema tests, resulting in a powerful inhibition of pro-inflammatory in vitro reactions, including UV-B-induced PGE2 release by keratinocytes [71].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [71]
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The Role of Polyphenols in Rosacea Treatment: A Systematic Review
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“Regarding human skin, licochalcone A has been associated with anti-inflammatory effects in vitro [10,11] and in vivo [11,12].”
Background
- Authors
- Kolbe, L., Immeyer, J., Batzer, J., Wensorra, U., Dieck, K. T., Mundt, C., Wolber, R., Stäb, F., Schönrock, U., Ceilley, R. I., & Wenck, H.
- Affiliations
- Beiersdorf (Germany) (DE)
- University of Iowa (US)
- Corresponding author
- Kolbe, Ludger
- Venue
- Archives of Dermatological Research
- Published
- 2006-03-22
- Volume
- 298
- Issue
- 1
- Pages
- 23-30
- ISSN
- 0003-9187 (ISSN-L)
- 0340-3696
- 1432-069X
- OpenAlex
- W2052562717
- Cited by
- 151
- References
- 18
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 5 · 2023: 4 · 2022: 11 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 5 · 2013: 12 · 2012: 5
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Dermatological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- licochalcone A, Glycyrrhiza inflata, licorice, anti-inflammatory activity, UV-induced erythema, respiratory burst, granulocytes, prostaglandin E2 release, leukotriene B4, lipopolysaccharide, interleukin-6, TNF-α, dendritic cells, keratinocytes, dermal fibroblasts
- MeSH terms
- Administration, Topical, Adult, Anti-Inflammatory Agents, Cells, Cultured, Erythema, Granulocytes, Humans, Leukotriene B4, Middle Aged, Plant Extracts, Prospective Studies, Tumor Necrosis Factor-alpha, Ultraviolet Rays, Zymosan, Dinoprostone, Keratinocytes, Interleukin-6, Respiratory Burst, Chalcones
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