Cited by 151Pharmacological Effects of Natural CompoundsSkin Protection and AgingPhytochemistry and Biological Activities

Anti-inflammatory efficacy of Licochalcone A: Correlation of clinical potency and in vitro effects

Kolbe, Ludger, Immeyer, Jeannine, Batzer, Jan, Wensorra, Ursula, Dieck, Karen tom, Mundt, Claudia, Wolber, Rainer, Stäb, Franz +3 more·2006·Archives of Dermatological Research

Abstract

Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-controlled clinical trials to assess the anti-irritative efficacy of cosmetic formulations containing LicA in a post-shaving skin irritation model and on UV-induced erythema formation. The clinical trials were accompanied by a series of in vitro experiments to characterize anti-inflammatory properties of LicA on several dermatologically relevant cell types. Topical LicA causes a highly significant reduction in erythema relative to the vehicle control in both the shave- and UV-induced erythema tests, demonstrating the anti-irritative properties of LicA. Furthermore, LicA is a potent inhibitor of pro-inflammatory in vitro responses, including N-formyl-MET-LEU-PHE (fMLP)- or zymosan-induced oxidative burst of granulocytes, UVB-induced PGE(2) release by keratinocytes, lipopolysaccharide (LPS)-induced PGE(2) release by adult dermal fibroblasts, fMLP-induced LTB(4) release by granulocytes, and LPS-induced IL-6/TNF-alpha secretion by monocyte-derived dendritic cells. The reported data suggest therapeutic skin care benefits from LicA when applied to sensitive or irritated skin.

Integrity signals

Registry

Crossref · 10.1007/s00403-006-0654-4

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A formulation with licochalcone A causes a highly noteworthy reduction in UV-induced erythema tests, resulting in powerful inhibition of pro-inflammatory in vitro reactions, including UV-B-induced PGE2 release by keratinocytes.

    “The formulation caused a highly noteworthy reduction in UV-induced erythema tests, resulting in a powerful inhibition of pro-inflammatory in vitro reactions, including UV-B-induced PGE2 release by keratinocytes [71].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kolbe, L., Immeyer, J., Batzer, J., Wensorra, U., Dieck, K. T., Mundt, C., Wolber, R., Stäb, F., Schönrock, U., Ceilley, R. I., & Wenck, H.
Affiliations
  • Beiersdorf (Germany) (DE)
  • University of Iowa (US)
Corresponding author
Kolbe, Ludger
Venue
Archives of Dermatological Research
Published
2006-03-22
Volume
298
Issue
1
Pages
23-30
ISSN
  • 0003-9187 (ISSN-L)
  • 0340-3696
  • 1432-069X
OpenAlex
W2052562717
Cited by
151
References
18
Citations by year
2026: 11 · 2025: 9 · 2024: 5 · 2023: 4 · 2022: 11 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 5 · 2013: 12 · 2012: 5
FWCI
4.28
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Dermatological Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords
licochalcone A, Glycyrrhiza inflata, licorice, anti-inflammatory activity, UV-induced erythema, respiratory burst, granulocytes, prostaglandin E2 release, leukotriene B4, lipopolysaccharide, interleukin-6, TNF-α, dendritic cells, keratinocytes, dermal fibroblasts
MeSH terms
Administration, Topical, Adult, Anti-Inflammatory Agents, Cells, Cultured, Erythema, Granulocytes, Humans, Leukotriene B4, Middle Aged, Plant Extracts, Prospective Studies, Tumor Necrosis Factor-alpha, Ultraviolet Rays, Zymosan, Dinoprostone, Keratinocytes, Interleukin-6, Respiratory Burst, Chalcones

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review