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Cited by 7Gestational Diabetes Research and ManagementDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

Estimated impact of introduction of new diagnostic criteria for gestational diabetes mellitus

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Wit, Leon de, Zijlmans, Anna B, Rademaker, Doortje, Naaktgeboren, Christiana A, DeVries, J Hans, Franx, Arie, Painter, Rebecca C, van Rijn, Bas B·2021·World Journal of Diabetes
DOI 10.4239/wjd.v12.i6.868PMC PMC8192254
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Abstract

BACKGROUND: Implementation of new diagnostic criteria for gestational diabetes mellitus (GDM) are still a subject of debate, mostly due to concerns regarding the effects on the number of women diagnosed with GDM and the risk profile of the women newly diagnosed. AIM: To estimate the impact of the World Health Organization (WHO) 2013 criteria compared with the WHO 1999 criteria on the incidence of gestational diabetes mellitus as well as to determine the diagnostic accuracy for detecting adverse pregnancy outcomes. METHODS: We retrospectively analyzed a single center Dutch cohort of 3338 women undergoing a 75 g oral glucose tolerance test where the WHO 1999 criteria to diagnose GDM were clinically applied. Women were categorized into four groups: non-GDM by both criteria, GDM by WHO 1999 only (excluded from GDM), GDM by WHO 2013 only (newly diagnosed) and GDM by both criteria. We compared maternal characteristics, pregnancy outcomes and likelihood ratios for adverse pregnancy outcomes. RESULTS: = 0.015). Positive likelihood ratios for adverse outcomes in all groups were generally low, ranging from 0.54 to 2.95. CONCLUSION: Applying the WHO 2013 criteria would result in a substantial increase in GDM diagnoses. Newly diagnosed women are at increased risk for pregnancy adverse outcomes. This risk, however, seems to be lower than those identified by the WHO 1999 criteria. This could potentially influence the treatment effect that can be achieved in this group. Evidence on treatment effects in newly diagnosed women is urgently needed.

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  • In a single-center cohort study from Utrecht, de Wit et al. confirmed an increase in GDM prevalence using IADPSG/WHO 2013 criteria compared to WHO 1999, at 32.4% vs. 19.3%.

    “In a single center cohort study from Utrecht de Wit et al. confirmed an increase in GDM prevalence using the IADPSG/WHO 2013 criteria compared to the WHO 1999 strategy, at 32.4% vs. 19.3% [149].”

    From Evolution of Gestational Diabetes Mellitus across Continents in 21st Century (2022) · cites this paper as [149]

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Authors
Wit, L. D., Zijlmans, A. B., Rademaker, D., Naaktgeboren, C. A., DeVries, J. H., Franx, A., Painter, R. C., & van Rijn, B. B.
Affiliations
  • University Medical Center Utrecht (NL)
  • Ziekenhuis Gelderse Vallei (NL)
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Erasmus MC (NL)
ORCID
Venue
World Journal of Diabetes
Publisher
Baishideng Publishing Group Inc.
Published
2021-06-15
Volume
12
Issue
6
Pages
868-882
ISSN
1948-9358 (ISSN-L)
DOI
10.4239/wjd.v12.i6.868
PMC
PMC8192254
OpenAlex
W3171612354
Cited by
7
References
11
Citations by year
2025: 1 · 2023: 2 · 2022: 4
FWCI
1.36
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Diabetes (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by-nc)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
gestational diabetes mellitus, diagnostic criteria, 75 g oral glucose tolerance test, incidence, adverse pregnancy outcomes, diagnostic accuracy, likelihood ratios, maternal characteristics

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