First experience with endovascular ultrasound renal denervation for the treatment of resistant hypertension
Abstract
AIMS: To evaluate a novel modality utilising ultrasound for renal denervation designed to reduce the duration of the intervention as well as to increase the consistency of the clinical outcome. METHODS AND RESULTS: Eleven consecutive patients suffering from resistant hypertension as defined by the ESH-ESC guidelines were treated by transcatheter renal denervation using the CE-marked PARADISE™ technology (ReCor Medical, Ronkonkoma, NY, USA). An average of 5.1 ultrasound emissions were delivered in each subject for a total denervation duration of less than four minutes and the treatment was well tolerated by all patients. Both office and home blood pressure measurements showed an immediate, significant and sustained decrease in blood pressure. Three-month results were comparable to published data on radiofrequency renal denervation with an average reduction in office and home blood pressure of -36/-17 mmHg and -22/-12 mmHg, respectively. CONCLUSIONS: Ultrasound renal denervation appears to be a safe and effective treatment for resistant hypertension and further studies will be performed to confirm these preliminary results.
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Efferent sympathetic renal denervation can be achieved with luminal delivery of radiofrequency and ultrasonic energy.
“Efferent sympathetic renal denervation can be achieved with luminal delivery of radiofrequency and ultrasonic energy.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [123]
In humans, the renal nerves pass from the sympathetic chain and ganglia to the kidneys via the outer adventitia of the renal arteries, or just beyond in perirenal adipose tissue and connective tissue, potentially within reach of radiofrequency energy delivered by a catheter in the artery lumen.
“In humans, the nerves pass from the sympathetic chain and ganglia to the kidneys via the outer adventitia of the renal arteries, or just beyond in perirenal adipose tissue and connective tissue, potentially within reach of radiofrequency energy delivered by a catheter in the artery lumen120–124.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [123]
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- Authors
- Mabin, T., Sapoval, M., Cabane, V., Stemmett, J., & Iyer, M.
- Corresponding author
- Mabin, Tom
- ORCID
- Sapoval, Marc
- Venue
- EuroIntervention
- Publisher
- Europa Digital & Publishing
- Published
- 2012-05
- Volume
- 8
- Issue
- 1
- Pages
- 57-61
- ISSN
- 1774-024X (ISSN-L)
- OpenAlex
- W2145427049
- Cited by
- 134
- References
- 14
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 9 · 2015: 17 · 2014: 44 · 2013: 22 · 2012: 4
- FWCI
- 17.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- EuroIntervention (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- resistant hypertension, renal denervation, catheter ablation, blood pressure reduction, treatment efficacy and safety
- MeSH terms
- Adult, Aged, Aged, 80 and over, Antihypertensive Agents, Blood Pressure, Drug Resistance, Feasibility Studies, Female, Humans, Hypertension, Kidney, Male, Middle Aged, South Africa, Time Factors, Ultrasonic Therapy, Treatment Outcome, Autonomic Denervation, Endovascular Procedures
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