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Cited by 97Atrial Fibrillation Management and OutcomesCoronary Interventions and DiagnosticsCardiovascular and Diving-Related Complications

Percutaneous left atrial appendage occlusion in patients with non-valvular atrial fibrillation: implantation and up to four years follow-up of the AMPLATZER Cardiac Plug

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Santoro, Gennaro, Meucci, Francesco, Stolcova, Miroslava, Rezzaghi, Marco, Mori, Fabio, Palmieri, Cataldo, Paradossi, Umberto, Pastormerlo, Luigi Emilio +2 more·2016·EuroIntervention
DOI 10.4244/eijy14m10_12
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Abstract

AIMS: Invasive imaging modalities have shown restoration of vasomotion, prevention of restenosis and, most importantly, increase in lumen area between six months and two years after first-generation everolimus-eluting bioresorbable vascular scaffold (Absorb BVS) implantation. Our aim was to assess whether these positive findings were sustained in the long term. METHODS AND RESULTS: Patients included in the ABSORB cohort A from the Thoraxcenter Rotterdam cohort underwent coronary catheterisation including angiography, intravascular ultrasound (IVUS), virtual histology, optical coherence tomography (OCT) and vasomotion testing at five years. Eight out of 16 patients underwent catheterisation and scaffold assessment with multiple imaging modalities. A trend towards an increase in minimum luminal diameter was observed between two and five years by angiography (1.95±0.37 mm vs. 2.14±0.38 mm; p=0.09). IVUS data showed an increase in mean lumen area at five years (6.96±1.13 mm2) compared to six months (6.17±0.74 mm2; p=0.06) and two years (6.56±1.16 mm2; p=0.12), primarily due to a persistent reduction in plaque area size between six months and five years (9.17±1.86 mm2 vs. 7.57±1.63 mm2; p=0.03). The necrotic core area was reduced at five years compared to post-procedural results. In OCT, an increase in mean and minimal luminal area was observed. Moreover, no scaffold struts could be identified and a smooth endoluminal lining was observed. The scaffolded coronary segment did not show signs of endothelial dysfunction with acetylcholine testing. CONCLUSIONS: At five years, the Absorb BVS is no longer discernible by any invasive imaging method and endothelial function is restored. Late luminal enlargement persists up to five years of follow-up without adaptive vessel remodelling.

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  1. Cutlip DE, Windecker S, Mehran R, Boam A, Cohen DJ, van Es GA, Steg PG, Morel MA, Mauri L, Vranckx P, McFadden E, Lansky A, Hamon M, Krucoff MW, Serruys PW; Academic Research Consortium. Clinical end points in coronary stent trials: a case for standardized definitions. Circulation. 2007;115:2344-51.
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Authors
Santoro, G., Meucci, F., Stolcova, M., Rezzaghi, M., Mori, F., Palmieri, C., Paradossi, U., Pastormerlo, L. E., Rosso, G., & Berti, S.
Affiliations
Erasmus MC (NL)
Venue
EuroIntervention
Publisher
Europa Digital & Publishing
Published
2016-02
Volume
11
Issue
10
Pages
1188-1194
ISSN
1774-024X (ISSN-L)
DOI
10.4244/eijy14m10_12
OpenAlex
W2417657882
Cited by
97
References
31
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 13 · 2019: 9 · 2018: 15 · 2017: 16 · 2016: 21 · 2015: 10 · 2014: 1
FWCI
16.77
Type
journal article
Language
en
Open access
Locations
  • EuroIntervention (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders
  • Erasmus Medisch Centrum
  • Abbott Vascular
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
Keywords
Amplatzer Cardiac Plug, left atrial appendage closure, non-valvular atrial fibrillation, percutaneous left atrial appendage closure, bioresorbable vascular scaffolds, everolimus-eluting scaffold, Absorb BVS, long-term follow-up, intravascular ultrasound, optical coherence tomography, virtual histology, restenosis, endothelial function, necrotic core, plaque area
MeSH terms
Everolimus, Aged, Cardiovascular Agents, Coronary Artery Disease, Coronary Vessels, Female, Humans, Male, Middle Aged, Necrosis, Netherlands, Predictive Value of Tests, Time Factors, Treatment Outcome, Coronary Angiography, Ultrasonography, Interventional, Coated Materials, Biocompatible, Absorbable Implants, Tomography, Optical Coherence, Plaque, Atherosclerotic, Percutaneous Coronary Intervention, Multimodal Imaging, Vascular Remodeling

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