RAS signaling pathways, mutations and their role in colorectal cancer

A genetic model for colorectal tumorigenesis

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The PI3K Pathway As Drug Target in Human Cancer

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The RASSF1A tumor suppressor

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The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

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Prevalence and Heterogeneity of KRAS, BRAF, and PIK3CA Mutations in Primary Colorectal Adenocarcinomas and Their Corresponding Metastases

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Biomarkers in Cancer Detection, Diagnosis, and Prognosis

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RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression

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Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease

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LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions

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Conceptual Evolution of Cell Signaling

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The Importance of Being PI3K in the RAS Signaling Network

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Emerging microRNAs in cancer diagnosis, progression, and immune surveillance

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miRNAs as cornerstones in colorectal cancer pathogenesis and resistance to therapy: A spotlight on signaling pathways interplay — A review

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Emerging Approaches to Overcome Acquired Drug Resistance Obstacles to Osimertinib in Non-Small-Cell Lung Cancer

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LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer

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Ellagic acid as a potent anticancer drug: A comprehensive review on in vitro, in vivo, in silico, and drug delivery studies

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A Gene Signature of Survival Prediction for Kidney Renal Cell Carcinoma by Multi-Omic Data Analysis

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Prevalence and coexistence of KRAS, BRAF, PIK3CA, NRAS, TP53, and APC mutations in Indian colorectal cancer patients: Next-generation sequencing–based cohort study

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Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes

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Exploring the Differential Expression and Prognostic Significance of the COL11A1 Gene in Human Colorectal Carcinoma: An Integrated Bioinformatics Approach

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Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis

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Current and Future Molecular Targets for Acute Myeloid Leukemia Therapy

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Lectins as mitosis stimulating factors: Briefly reviewed

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Therapeutic targeting of Ras/Raf/MAPK pathway by natural products: A systematic and mechanistic approach for neurodegeneration

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Targeting the RAS upstream and downstream signaling pathway for cancer treatment

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Implications of farnesyltransferase and its inhibitors as a promising strategy for cancer therapy

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In vitro characterization of spheres derived from colorectal cancer cell lines

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Highlights on Specific Biological Targets; Cyclin-Dependent Kinases, Epidermal Growth Factor Receptors, Ras Protein, and Cancer Stem Cells in Anticancer Drug Development

Hawash, M. (2019) · Drug Research · doi:10.1055/a-0898-7347 · Cited by 46

Role of Human Galectins in Inflammation and Cancers Associated with Endometriosis

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Paradoxical effects of statins on endothelial and cancer cells: the impact of concentrations

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Emerging methods and techniques for cancer biomarker discovery

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Monoterpenoids: An upcoming class of therapeutic agents for modulating cancer metastasis

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Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma

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Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer

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Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells

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Oncolytic Viruses as Therapeutic Tools for Pediatric Brain Tumors

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Molecular detection of exosomal miRNAs of blood serum for prognosis of colorectal cancer

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Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression

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Identification of genes critical for inducing ulcerative colitis and exploring their tumorigenic potential in human colorectal carcinoma

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Dietary Insulin Load and Cancer Recurrence and Survival in Patients With Stage III Colon Cancer: Findings From CALGB 89803 (Alliance)

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Molecular characterization of colorectal cancer using whole‐exome sequencing in a Taiwanese population

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Factors regulating dynamics of angiotensin-converting enzyme-2 (ACE2), the gateway of SARS-CoV-2: Epigenetic modifications and therapeutic interventions by epidrugs

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Genome-wide Analysis Reveals DNA Methylation Alterations in Obesity Associated with High Risk of Colorectal Cancer

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Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of small interfering RNA

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Frequency and coexistence of KRAS, NRAS, BRAF and PIK3CA mutations and occurrence of MMR deficiency in Danish colorectal cancer patients

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Transcriptional Profiles of Skeletal Muscle Associated With Increasing Severity of White Striping in Commercial Broilers

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Diterpenoid C of Radix Curcumae: An inhibitor of proliferation and inducer of apoptosis in human colon adenocarcinoma cells acting via inhibiting MAPK signaling pathway

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Clinical performance evaluation of the Idylla NRAS-BRAF mutation test on retrospectively collected formalin-fixed paraffin-embedded colorectal cancer tissue

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Inducible Intestine-Specific Expression of kras Triggers Intestinal Tumorigenesis In Transgenic Zebrafish

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Complex karyotype in myelodysplastic syndromes: Diagnostic procedure and prognostic susceptibility

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Clinical Translation of Combined MAPK and Autophagy Inhibition in RAS Mutant Cancer

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Significance of histone methyltransferase SETDB 1 expression in colon adenocarcinoma

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Immune-Related Nine-MicroRNA Signature for Predicting the Prognosis of Gastric Cancer

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Miniaturized Real-Time PCR on a Q3 System for Rapid KRAS Genotyping

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Penicillium genus as a source for anti-leukemia compounds: an overview from 1984 to 2020

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Oxygen and viruses: a breathing story

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Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrations

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β-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer

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Emerging drug targets for colon cancer: A preclinical assessment

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Genome-wide methylation analysis identifies novel prognostic methylation markers in colon adenocarcinoma

Xue, W., Wu, X., Wang, F., Han, P., & Cui, B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.043 · Cited by 15

KRAS-associated microRNAs in colorectal cancer

Ibrahim, H., & Lim, Y. C. (2020) · Oncology Reviews · doi:10.4081/oncol.2020.454 · Cited by 14

Immune response in colorectal carcinoma: a review of its significance as a predictive and prognostic biomarker

Bell, P. D., & Pai, R. K. (2022) · Histopathology · doi:10.1111/his.14713 · Cited by 14

Translational research of new developments in targeted therapy of colorectal cancer

Yang, L., Atakhanova, N. E., Arellano, M. T. C., Mohamed, M. Y., Hani, T., Fahdil, A. A., Castillo-Acobo, R. Y., Juyal, A., Hussein, A. K., Amin, A. H., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154888 · Cited by 14

Microvesicles mediate sorafenib resistance in liver cancer cells through attenuating p53 and enhancing FOXM1 expression

Ali, D. J., He, C., Xu, H., Kumaravel, S., Sun, B., Zhou, Y., Liu, R., & Xiao, Z. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119149 · Cited by 14

Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance

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Integrated analysis of cell cycle and p53 signaling pathways related genes in breast, colorectal, lung, and pancreatic cancers: implications for prognosis and drug sensitivity for therapeutic potential

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Hyaluronic acid cloaked oleic acid nanoparticles inhibit MAPK signaling with sub-cellular DNA damage in colon cancer cells

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Reciprocal Graphical Models for Integrative Gene Regulatory Network Analysis

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IDENTIFICATION OF MUTANT K-RAS IN PITUITARY MACROADENOMA

Aran, V., Heringer, M., Pereira, P. J. D. M., Kasuki, L., Miranda, R. L., Andreiuolo, F. D. M., Chimelli, L. M. C., Filho, P. N., Gadelha, M. R., & Moura‐Neto, V. (2021) · Pituitary · doi:10.1007/s11102-021-01151-6 · Cited by 13

Hsa-miR-6165 downregulates insulin-like growth factor-1 receptor (IGF-1R) expression and enhances apoptosis in SW480 cells

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Performance of Idylla™ RAS-BRAF mutation test for formalin-fixed paraffin-embedded tissues of colorectal cancer

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Innovative dual system approach for selective eradication of cancer cells using viral-based delivery of natural bacterial toxin–antitoxin system

Shapira, S., Boustanai, I., Kazanov, D., Shimon, M. B., Fokra, A., & Arber, N. (2021) · Oncogene · doi:10.1038/s41388-021-01792-8 · Cited by 11

Drug Target Identification in Triple Negative Breast Cancer Stem Cell Pathways: A Computational Study of Gene Regulatory Pathways Using Boolean Networks

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The non-enzymatic RAS effector RASSF7 inhibits oncogenic c-Myc function

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A phase I study of the farnesyltransferase inhibitor Tipifarnib in combination with the epidermal growth factor tyrosine kinase inhibitor Erlotinib in patients with advanced solid tumors

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Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells

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RAS Mutations in Advanced Colorectal Cancer: Mechanisms, Clinical Implications, and Novel Therapeutic Approaches

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Advances in the Diagnosis and Treatment of Myeloproliferative Neoplasms (MPNs)

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The potential of PIK3CA, KRAS, BRAF, and APC hotspot mutations as a non-invasive detection method for colorectal cancer

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Mutational landscape of pan-cancer patients with PIK3CA alterations in Chinese population

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Relevance of different prior knowledge sources for inferring gene interaction networks

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Molecular characteristics of uveal melanoma and intraocular tumors (Review)

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