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RAS signaling pathways, mutations and their role in colorectal cancer
Open accessAbstract
Two of the main cellular pathways in which the RAS protein operates are the mitogen-activated protein kinases (MAPK) and phosphoinositide-3 kinase (PI3K) pathways. In a normal cell, these are important in controlling several functions, such as cell growth and survival. It becomes self-evident that these events will be disrupted in a malignant cell with a deregulated MAPK or PI3K pathway. Mutations in genes involved in these pathways and interacting with RAS, as well as RAS itself will be discussed. The second part of this review concentrates on how crucial RAS signaling is in colorectal cancer progression, with references to treatment response and prognosis when RAS or other related mutations are present.
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“They are also associated with lower response rates to chemotherapy and shorter overall survival in several clinical cohorts [7].”
From RAS Mutations in Advanced Colorectal Cancer: Mechanisms, Clinical Implications, and Novel Therapeutic Approaches (2025) · cites this paper as [7]
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Additional file 1 of Prognostic value and biological function of LRRN4 in colorectal cancer
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Additional file 4 of Prognostic value and biological function of LRRN4 in colorectal cancer
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Additional file 5 of Prognostic value and biological function of LRRN4 in colorectal cancer
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Metadata
- Authors
- Zenonos, K.
- Affiliations
- University of Birmingham (GB)
- Corresponding author
- Zenonos, Kypros
- Venue
- World Journal of Gastrointestinal Oncology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2013
- Volume
- 5
- Issue
- 5
- Pages
- 97
- ISSN
- 1948-5204 (ISSN-L)
- PMC
- PMC3682174
- OpenAlex
- W2080354187
- Cited by
- 156
- References
- 32
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 11 · 2023: 15 · 2022: 27 · 2021: 19 · 2020: 15 · 2019: 13 · 2018: 15 · 2017: 12 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 1
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastrointestinal Oncology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- Ras signaling, colorectal cancer, RAS mutations, MAPK signaling, PI3K signaling, tumor progression, treatment response, prognosis, cell growth and survival
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