The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Role of Hox genes in stem cell differentiation
Open accessAbstract
Hox genes are an evolutionary highly conserved gene family. They determine the anterior-posterior body axis in bilateral organisms and influence the developmental fate of cells. Embryonic stem cells are usually devoid of any Hox gene expression, but these transcription factors are activated in varying spatial and temporal patterns defining the development of various body regions. In the adult body, Hox genes are among others responsible for driving the differentiation of tissue stem cells towards their respective lineages in order to repair and maintain the correct function of tissues and organs. Due to their involvement in the embryonic and adult body, they have been suggested to be useable for improving stem cell differentiations in vitro and in vivo. In many studies Hox genes have been found as driving factors in stem cell differentiation towards adipogenesis, in lineages involved in bone and joint formation, mainly chondrogenesis and osteogenesis, in cardiovascular lineages including endothelial and smooth muscle cell differentiations, and in neurogenesis. As life expectancy is rising, the demand for tissue reconstruction continues to increase. Stem cells have become an increasingly popular choice for creating therapies in regenerative medicine due to their self-renewal and differentiation potential. Especially mesenchymal stem cells are used more and more frequently due to their easy handling and accessibility, combined with a low tumorgenicity and little ethical concerns. This review therefore intends to summarize to date known correlations between natural Hox gene expression patterns in body tissues and during the differentiation of various stem cells towards their respective lineages with a major focus on mesenchymal stem cell differentiations. This overview shall help to understand the complex interactions of Hox genes and differentiation processes all over the body as well as in vitro for further improvement of stem cell treatments in future regenerative medicine approaches.
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Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
Hajer, G. R., van Haeften, T. W., & Visseren, F. L. J. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn387 · Cited by 1,410
Modulating Hox gene functions during animal body patterning
Pearson, J. C., Lemons, D., & McGinnis, W. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1726 · Cited by 879
Retinoic acid in development: Towards an integrated view
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Signals and switches in mammalian neural crest cell differentiation
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Cited by
Key transcription factors in the differentiation of mesenchymal stem cells
Almalki, S. G., & Agrawal, D. K. (2016) · Differentiation · doi:10.1016/j.diff.2016.02.005 · Cited by 420
Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells
Qadir, A., Liang, S., Wu, Z., Chen, Z., Hu, L., & Qian, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010349 · Cited by 268
Garcia-Gomez, A., Li, T., de la Calle-Fabregat, C., Rodríguez-Ubreva, J., Ciudad, L., Català-Moll, F., Godoy-Tena, G., Martín-Sánchez, M., San-Segundo, L., Muntión, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20715-x · Cited by 57
Carnesecchi, J., Boumpas, P., van Nierop y Sanchez, P., Domsch, K., Pinto, H. D., Borges Pinto, P., & Lohmann, I. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1250 · Cited by 25
A Live Cell Protein Complementation Assay for ORFeome-Wide Probing of Human HOX Interactomes
Jia, Y., Reboulet, J., Gillet, B., Hughes, S., Forcet, C., Tribollet, V., Hajj Sleiman, N., Kundlacz, C., Vanacker, J.-M., Bleicher, F., et al. (2023) · Cells · doi:10.3390/cells12010200 · Cited by 10
Metadata
- Authors
- Seifert, A.
- Venue
- World Journal of Stem Cells
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2015
- Volume
- 7
- Issue
- 3
- Pages
- 583
- ISSN
- 1948-0210 (ISSN-L)
- OpenAlex
- W2398852852
- Cited by
- 165
- References
- 8
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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