The DOI matches its Crossref record.
Observations on Two Plasmodium Falciparum Infections with an Abnormal Response to Chloroquine
Abstract
SummaryThe first of two patients with Plasmodium falciparum infections which failed to respond to chloroquine therapy administered in Colombia, South America, received three further courses of 1.5 g of chloroquine and experienced clinical and parasitic relapses 12 and 8 days, respectively, after the first two courses. Upon the completion of the third course the drug was continued for 14 more days at a dosage of 0.3 g daily. Blood smears remained positive during this period. A 3-day course of quinine sulphate (90 grains) produced negative blood smears, but a parasitic relapse occurred after 17 days. An apparent cure was effected by a 10-day course of quinine.The second patient experienced a clinical and parasitic relapse approximately 20 days after a first course of chloroquine; and after a second course (2.1 g) followed by a 14-day course of primaquine, a recurrence of parasitemia accompanied by minor symptoms approximately 21 days after the completion of the chloroquine therapy was observed. A 10-day course of quinine produced an apparent cure.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Reversal of Chloroquine Resistance in Plasmodium falciparum by Verapamil
Martin, S. K., Oduola, A. M. J., & Milhous, W. K. (1987) · Science · doi:10.1126/science.3544220 · Cited by 579
Foote, S. J., Thompson, J. K., Cowman, A. F., & Kemp, D. J. (1989) · Cell · doi:10.1016/0092-8674(89)90330-9 · Cited by 573
Mechanisms of Resistance of Malaria Parasites to Antifolates
Gregson, A., & Plowe, C. V. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.4 · Cited by 499
Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator
Hänscheid, T., Egan, T. J., & Grobusch, M. P. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70238-4 · Cited by 128
Sridaran, S., McClintock, S. K., Syphard, L. M., Herman, K. M., Barnwell, J. W., & Udhayakumar, V. (2010) · Malaria Journal · doi:10.1186/1475-2875-9-247 · Cited by 124
Metadata
- Authors
- Moore, D. V., & Lanier, J. E.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1961-01
- Volume
- 10
- Issue
- 1
- Pages
- 5-9
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2416597985
- Cited by
- 259
- References
- 0
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Observations on Two Plasmodium Falciparum Infections with an Abnormal Response to Chloroquine. https://app.cochat.ai/papers/10.4269/ajtmh.1961.10.5
- The paper
- Moore, D. V., & Lanier, J. E. (1961). Observations on Two Plasmodium Falciparum Infections with an Abnormal Response to Chloroquine. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.1961.10.5
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
