Release of prostaglandin E2 by microfilariae of Wuchereria bancrofti and Brugia malayi
Abstract
To elucidate the local release of immunomodulatory prostaglandins by intravascular filarial parasites, the formation of prostaglandin E2 (PGE2) was examined in individual microfilariae of Wuchereria bancrofti and Brugia malayi. Following incubation of living microfilariae immobilized in an agar matrix, prostaglandins released by the parasites were fixed by carbodiimide and localized by indirect immunofluorescence. Prostaglandin E2 was specifically detected around the entire surface of microfilariae with anti-PGE2 antiserum, but not with control nonimmune or PGE2 affinity-immunoadsorbed antiserum. These results provide direct evidence that individual microfilariae of W. bancrofti as well as B. malayi release prostaglandins into their microenvironment. The release of PGE2 by these intravascular parasites may modulate host leukocyte responses, and thereby contribute to the immune defects observed in infected humans with peripheral microfilaremia.
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T. suis, S. mansoni, and filarial nematode secretions contain PGE2.
“T. suis, S. mansoni, and filarial nematode secretions contain PGE2 (Laan et al., 2017, Liu et al., 1992)”
From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as Liu et al., 1992
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Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules
Maizels, R. M., Smits, H. H., & McSorley, H. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.016 · Cited by 435 · see citing works
D’Avila, H., Melo, R. C. N., Parreira, G. G., Werneck-Barroso, E., Castro-Faria-Neto, H. C., & Bozza, P. T. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.5.3087 · Cited by 289 · see citing works
Osborne, J., & Devaney, E. (1999) · Infection and Immunity · doi:10.1128/iai.67.4.1599-1605.1999 · Cited by 77 · see citing works
Morchón, R., Roca, F., López-Belmonte, J., Genchi, M., Venco, L., Rodríguez-Barbero, A., & Simón, F. (2007) · Veterinary Parasitology · doi:10.1016/j.vetpar.2007.04.010 · Cited by 12 · see citing works
- Authors
- Liu, L. X., Buhlmann, J. E., & Weller, P. F.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1992-05
- Volume
- 46
- Issue
- 5
- Pages
- 520-523
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2413890310
- Cited by
- 58
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r22ai023826-03, 5k11ai000965-02)
- National Institute of Allergy and Infectious Diseases (K11 AI00965, AI 23826)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Keywords
- prostaglandin E2, microfilariae, Wuchereria bancrofti, Brugia malayi, filarial nematodes, immunomodulation, host-parasite interactions, leukocyte response
- MeSH terms
- Animals, Brugia, Fluorescent Antibody Technique, Humans, Microfilariae, Wuchereria bancrofti, Dinoprostone
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