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Cited by 12Parasitic Diseases Research and TreatmentHelminth infection and controlParasites and Host Interactions

Changes in the levels of eicosanoids in cats naturally and experimentally infected with Dirofilaria immitis

Morchón, R., Roca, F., López-Belmonte, J., Genchi, M., Venco, L., Rodríguez-Barbero, A., Simón, F.·2007·Veterinary Parasitology
DOI 10.1016/j.vetpar.2007.04.010
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Abstract

Feline heartworm (Dirofilaria immitis) infection is a severe, life-threatening disease. The eicosanoids are lipid mediators derived from the metabolism of the arachidonic acid, involved in the regulation of the immune response and of inflammatory reactions. In this study, naturally infected cats showed significant higher levels of prostaglandin E(2) (PGE2), thromboxane B(2) (TXB(2)) and leukotriene B(4) (LTB4) than uninfected cats. Changes in the levels of eicosanoids during the infection were observed in experimentally infected cats. PGE2 increased significantly during the first 60 days post-infection, then progressively decreased until day 180 post-infection. At this time, PGE2 values are still significantly higher than those observed before the infection. TxB2 and LTB4 increased progressively from the beginning of infection and reached their maximum levels 180 days post-infection. In experimentally infected, ivermectin-treated cats, 15 days after treatment (45 days after infection) both PGE2 and LTB4 levels were similar to those observed in experimentally infected, untreated cats. No significant differences of PGE2 levels were found before the infection and at the end of the experiment (165 days post-treatment, 195 days post-infection). Increased levels of LTB4 were found 15 days post-treatment, afterward they progressively decreased. These data show that D. immitis infection influences the production of intravascular eicosanoids in cats. The high levels of PGE2 observed in the early phase of infection could be related to the survival of the worms, while those of TxB2 and LTB4 detected at the end of the study could mediate the inflammatory reactions and thrombi formation during the feline dirofilariosis.

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Crossref · 10.1016/j.vetpar.2007.04.010

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  • In experimental feline D. immitis infections, thromboxane B2 (TxB2) and leukotriene B4 (LTB4) reach maximal levels at 180 days post-infection, when inflammatory and obstructive reactions begin as preadult worms reach pulmonary arteries.

    “In experimental feline infections, both thromboxane B2 (TxB2), which stimulates vasoconstriction, platelet aggregation, and the proinflammatory Th1 response, and leukotriene B4 (LTB4), which is active in chemotactic and leukocyte activation (369), reach their maximal levels at 180 d.p.i., when inflammatory and obstructive reactions begin as preadult worms reach the pulmonary arteries (295).”

    From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [295]

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Authors
Morchón, R., Roca, F., López-Belmonte, J., Genchi, M., Venco, L., Rodríguez-Barbero, A., & Simón, F.
Affiliations
  • Universidad de Salamanca (ES)
  • University of Puerto Rico, Medical Sciences Campus (PR)
  • University of Milan (IT)
Corresponding author
Simón, F.
ORCID
Venue
Veterinary Parasitology
Publisher
Elsevier BV
Published
2007-07
Volume
147
Issue
3-4
Pages
271-275
ISSN
0304-4017 (ISSN-L)
DOI
10.1016/j.vetpar.2007.04.010
OpenAlex
W1984855515
Cited by
12
References
24
Citations by year
2017: 1 · 2015: 1 · 2013: 1 · 2012: 2
FWCI
1.48
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Veterinary Parasitology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministerio de Ciencia y Tecnología
Topics
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
  • Health Sciences › Veterinary › Small Animals › Helminth infection and control
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Keywords
feline heartworm disease, Dirofilaria immitis, eicosanoids, prostaglandin E2, thromboxane B2, leukotriene B4, arachidonic acid metabolism, ivermectin treatment, experimental infection, inflammation, thrombosis, cats
MeSH terms
Animals, Cat Diseases, Cats, Dirofilaria immitis, Dirofilariasis, Eicosanoids

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