The DOI matches its Crossref record.
Parasite Lactate Dehydrogenase as an Assay for Plasmodium falciparum Drug Sensitivity
Abstract
This report compares the use of the lactate dehydrogenase (pLDH) assay with 3H-hypoxanthine incorporation and Giemsa microscopy for the evaluation of anti-malaria drug inhibition of the growth of P. falciparum in vitro. The inhibition profiles and IC50 determinations of the pLDH assay were directly comparable to those determined by the radioactive uptake and microscopic methods. Furthermore, the pLDH culture sensitivity assay is reproducible, easily interpreted, rapid and inexpensive to perform, suggesting field applicability.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Rapid Diagnostic Tests for Malaria Parasites
Moody, A. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.1.66-78.2002 · Cited by 1,418
In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa
Clarkson, C., Maharaj, V. J., Crouch, N. R., Grace, O. M., Pillay, P., Matsabisa, M. G., Bhagwandin, N., Smith, P. J., & Folb, P. I. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.02.011 · Cited by 592
Toxicity of Nanomaterials: Exposure, Pathways, Assessment, and Recent Advances
Ganguly, P., Breen, A., & Pillai, S. C. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00068 · Cited by 341
Rickards, R. W., Rothschild, J. M., Willis, A. C., de Chazal, N. M., Kirk, J., Kirk, K., Saliba, K. J., & Smith, G. D. (1999) · Tetrahedron · doi:10.1016/s0040-4020(99)00833-9 · Cited by 249
Antimicrobial and antiprotozoal activities of twenty-four Nigerian medicinal plant extracts
Ogbole, O. O., Segun, P. A., & Fasinu, P. S. (2018) · South African Journal of Botany · doi:10.1016/j.sajb.2018.05.028 · Cited by 52
Metadata
- Authors
- Makler, M. T., Ries, J. M., Williams, J. A., Bancroft, J. E., Piper, R. C., Gibbins, B. L., & Hinrichs, D. J.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1993-06
- Volume
- 48
- Issue
- 6
- Pages
- 739-741
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2296263363
- Cited by
- 740
- References
- 0
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Parasite Lactate Dehydrogenase as an Assay for Plasmodium falciparum Drug Sensitivity. https://app.cochat.ai/papers/10.4269/ajtmh.1993.48.739
- The paper
- Makler, M. T., Ries, J. M., Williams, J. A., Bancroft, J. E., Piper, R. C., Gibbins, B. L., & Hinrichs, D. J. (1993). Parasite Lactate Dehydrogenase as an Assay for Plasmodium falciparum Drug Sensitivity. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.1993.48.739
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
