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AN ULTRASTRUCTURAL STUDY OF THE BRAIN IN FATAL PLASMODIUM FALCIPARUM MALARIA
Abstract
Cerebral malaria (CM) is a major cause of death in severe Plasmodium falciparum malaria. We present quantitative electron microscopic findings of the neuropathologic features in a prospective clinicopathologic study of 65 patients who died of severe malaria in Thailand and Vietnam. Sequestration of parasitized red blood cells (PRBCs) in cerebral microvessels was significantly higher in the brains of patients with CM compared with those with non-cerebral malaria (NCM) in all parts of the brain (cerebrum, cerebellum, and medulla oblongata). There was a hierarchy of sequestration with more in the cerebrum and cerebellum than the brain stem. When cerebral sequestration was compared with the peripheral parasitemia pre mortem, there were 26.6 times more PRBCs in the brain microvasculature than in the peripheral blood. The sequestration index was significantly higher in CM patients (median = 50.7) than in NCM patients (median = 6.9) (P = 0.042). The degree of sequestration of P. falciparum-infected erythrocytes in cerebral microvessels is quantitatively associated with pre-mortem coma.
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Cited by
White, N. J., Pukrittayakamee, S., Hien, T. T., Faiz, M. A., Mokuolu, O. A., & Dondorp, A. M. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60024-0 · Cited by 1,123
Self-citationEstimation of the Total Parasite Biomass in Acute Falciparum Malaria from Plasma PfHRP2
Dondorp, A. M., Desakorn, V., Pongtavornpinyo, W., Sahassananda, D., Silamut, K., Chotivanich, K., Newton, P. N., Pitisuttithum, P., Smithyman, A. M., White, N. J., et al. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020204 · Cited by 448
Self-citationWhite, N. J. (2017) · Malaria Journal · doi:10.1186/s12936-017-1731-1 · Cited by 230
Self-citationEpidemiology, drug resistance, and pathophysiology of Plasmodium vivax malaria
Gowda, D., Dayananda, K., & Achur, R. (2018) · Journal of Vector Borne Diseases · doi:10.4103/0972-9062.234620 · Cited by 111
Fairhurst, R. M., & Wellems, T. E. (2006) · Current Opinion in Hematology · doi:10.1097/01.moh.0000219655.73162.42 · Cited by 31
Metadata
- Authors
- PONGPONRATN, E., TURNER, G. D. H., DAY, N. P. J., PHU, N. H., SIMPSON, J. A., STEPNIEWSKA, K., MAI, N. T. H., VIRIYAVEJAKUL, P., LOOAREESUWAN, S., HIEN, T. T., FERGUSON, D. J. P., & WHITE, N. J.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2003-10
- Volume
- 69
- Issue
- 4
- Pages
- 345-359
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W1955203614
- Cited by
- 240
- References
- 0
- FWCI
- 10.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- PONGPONRATN, E., TURNER, G. D. H., DAY, N. P. J., PHU, N. H., SIMPSON, J. A., STEPNIEWSKA, K., MAI, N. T. H., VIRIYAVEJAKUL, P., LOOAREESUWAN, S., HIEN, T. T., FERGUSON, D. J. P., & WHITE, N. J. (2003). AN ULTRASTRUCTURAL STUDY OF THE BRAIN IN FATAL PLASMODIUM FALCIPARUM MALARIA. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.2003.69.345
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
