The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
THE EFFECTS OF PLASMODIUM FALCIPARUM AND P. VIVAX INFECTIONS ON PLACENTAL HISTOPATHOLOGY IN AN AREA OF LOW MALARIA TRANSMISSION
Open accessAbstract
Placental histopathology was studied in a cohort of 204 women living in an area of low Plasmodium falciparum and P. vivax malaria transmission. Detection of malaria antenatally was active, by weekly peripheral blood smears, and all infections were treated. Significant histopathologic placental malaria changes (increased malaria pigment, cytotrophoblastic prominence, and presence of parasites) were found only in a minority of women who had P. falciparum infections in pregnancy. These changes were significantly more frequent in women with evidence of peripheral blood infection close to delivery and only in these cases were placental inflammatory cells increased. Antenatal P. vivax infection was associated only with the presence of malaria pigment in the placenta. All placental infections diagnosed by blood smear and 32.4% (12 of 37) diagnosed by histopathology were associated with patent peripheral parasitemia. This study indicates that prompt treatment of peripheral parasitemias during pregnancy limits placental pathology. The effect on birth weight reduction may not result from irreversible placental changes but from the acute insult of infection. These findings emphasize the importance of treating malaria in pregnancy promptly with effective antimalarial drugs.
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“Vivax parasites do not frequently express variant surface antigens, at the basis of placenta sequestration, so that this does not occur frequently.81”
From Malaria in pregnancy. (2013) · cites this paper as [81]
In the citing paper
“women with malaria detected by weekly ante natal screenings and effective treatment often have no histological changes at delivery [56,57].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [56]
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Desai, M., ter Kuile, F. O., Nosten, F., McGready, R., Asamoa, K., Brabin, B., & Newman, R. D. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70021-x · Cited by 1,432
Self-citationVivax Malaria: Neglected and Not Benign
Price, R. N., Tjitra, E., Guerra, C. A., Yeung, S., White, N. J., & Anstey, N. M. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.77.79 · Cited by 840
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Rogerson, S. J., Hviid, L., Duffy, P. E., Leke, R. F., & Taylor, D. W. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70022-1 · Cited by 628
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Metadata
- Authors
- McGREADY, R., DAVISON, B. B., STEPNIEWSKA, K., CHO, T., SHEE, H., BROCKMAN, A., UDOMSANGPETCH, R., LOOAREESUWAN, S., WHITE, N. J., MESHNICK, S. R., & NOSTEN, F.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Shoklo Malaria Research Unit, Mae Sot, Thailand; Faculty of Tropical Medicine, and Faculty of Science, Mahidol University, Bangkok, Thailand; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana; Departments of Epidemiology and Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2004-04
- Volume
- 70
- Issue
- 4
- Pages
- 398-407
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2102655747
- Cited by
- 170
- References
- 46
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 17 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 4 · 2015: 10 · 2014: 7 · 2013: 17 · 2012: 16
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- green
- cdr.lib.unc.edu
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (5r01ai042400-05)
- National Institute of Allergy and Infectious Diseases (5R01AI42400)
- National Center for Research Resources (P51-RR-00164, P51RR000164)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
- Keywords
- Plasmodium falciparum, Plasmodium vivax, placental malaria, placental pathology, malaria in pregnancy, hemozoin, placental inflammation, low malaria transmission
- MeSH terms
- Adolescent, Adult, Animals, Antimalarials, Female, Fetal Blood, Histocytochemistry, Humans, Infant, Low Birth Weight, Infant, Newborn, Placenta, Plasmodium falciparum, Plasmodium vivax, Pregnancy, Prospective Studies, Thailand, Cohort Studies, Pregnancy Complications, Parasitic, Malaria, Falciparum, Malaria, Vivax, Parasitemia
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