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THE ETIOLOGY OF FEBRILE ILLNESS IN ADULTS PRESENTING TO PATAN HOSPITAL IN KATHMANDU, NEPAL
Abstract
In Nepal, many infections remain poorly characterized, partly due to limited diagnostic facilities. We studied consecutive febrile adults presenting to a general hospital in Kathmandu, Nepal. Of the 876 patients enrolled, enteric fever and pneumonia were the most common clinical diagnoses. Putative pathogens were identified in 323 (37%) patients, the most common being Salmonella enterica serotype Typhi and S. enterica serotype Paratyphi A (117), Rickettsia typhi (97), Streptococcus pneumoniae (53), Leptospira spp. (36), and Orientia tsutsugamushi (28). Approximately half of the Salmonella isolates were resistant to nalidixic acid. No clinical predictors were identified to reliably distinguish between the different infections. These findings confirm the heavy burden of enteric fever and pneumonia in Kathmandu, and highlight the importance of murine typhus, scrub typhus, and leptospirosis. Given the lack of reliable clinical predictors, the development of cheap and accurate diagnostic tests are likely to be of great clinical utility in this setting.
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Cited by
Non-prescription antimicrobial use worldwide: a systematic review
Morgan, D. J., Okeke, I. N., Laxminarayan, R., Perencevich, E. N., & Weisenberg, S. (2011) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70054-8 · Cited by 947
McBride, A. J., Athanazio, D. A., Reis, M. G., & Ko, A. I. (2005) · Current Opinion in Infectious Diseases · doi:10.1097/01.qco.0000178824.05715.2c · Cited by 518
Leptospirosis in the Asia Pacific region
Victoriano, A. F. B., Smythe, L. D., Gloriani-Barzaga, N., Cavinta, L. L., Kasai, T., Limpakarnjanarat, K., Ong, B. L., Gongal, G., Hall, J., Coulombe, C. A., et al. (2009) · BMC Infectious Diseases · doi:10.1186/1471-2334-9-147 · Cited by 373
Etiology of Central Nervous System Infections in a Rural Area of Nepal Using Molecular Approaches
Säll, O., Thulin Hedberg, S., Neander, M., Tiwari, S., Dornon, L., Bom, R., Lagerqvist, N., Sundqvist, M., & Mölling, P. (2019) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.18-0434 · Cited by 20
Metadata
- Authors
- MURDOCH, D. R., WOODS, C. W., ZIMMERMAN, M. D., DULL, P. M., BELBASE, R. H., KEENAN, A. J., SCOTT, R. M., BASNYAT, B., ARCHIBALD, L. K., & RELLER, L. B.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2004-06
- Volume
- 70
- Issue
- 6
- Pages
- 670-675
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2122999487
- Cited by
- 203
- References
- 0
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- MURDOCH, D. R., WOODS, C. W., ZIMMERMAN, M. D., DULL, P. M., BELBASE, R. H., KEENAN, A. J., SCOTT, R. M., BASNYAT, B., ARCHIBALD, L. K., & RELLER, L. B. (2004). THE ETIOLOGY OF FEBRILE ILLNESS IN ADULTS PRESENTING TO PATAN HOSPITAL IN KATHMANDU, NEPAL. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.2004.70.670
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