The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Convergent Antibody Signatures in Human Dengue
Open accessAbstract
SUMMARY Dengue is the most prevalent mosquito-transmitted viral disease in humans, and the lack of early prognostics, vaccines and therapeutics contributes to immense disease burden. To identify patterns that could be used for sequence-based monitoring of the antibody response to dengue, we examined antibody heavy-chain gene rearrangements in longitudinal peripheral blood samples from 60 dengue patients. Comparing signatures between acute dengue, post-recovery and healthy samples, we find increased expansion of B cell clones in acute dengue patients, with higher overall clonality in secondary infection. Additionally, we observe consistent antibody sequence features in acute dengue in the major antigen-binding determinant Complementarity Determining Region-3 (CDR3), with specific CDR3 sequences highly enriched in acute samples compared to post-recovery, healthy or non-dengue samples. Dengue thus provides a striking example of a human viral infection where convergent immune signatures can be identified in multiple individuals. Such signatures could facilitate surveillance of immunological memory in communities.
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Metadata
- Authors
- Parameswaran, P., Liu, Y., Roskin, K. M., Jackson, K. K. L., Dixit, V. P., Lee, J.-Y., Artiles, K. L., Zompi, S., Vargas, M. J., Simen, B. B., Hanczaruk, B., McGowan, K. R., Tariq, M. A., Pourmand, N., Koller, D., Balmaseda, A., Boyd, S. D., Harris, E., & Fire, A. Z.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 13
- Issue
- 6
- Pages
- 691-700
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2018339091
- Cited by
- 261
- References
- 40
- FWCI
- 23.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Parameswaran, P., Liu, Y., Roskin, K. M., Jackson, K. K. L., Dixit, V. P., Lee, J.-Y., Artiles, K. L., Zompi, S., Vargas, M. J., Simen, B. B., Hanczaruk, B., McGowan, K. R., Tariq, M. A., Pourmand, N., Koller, D., Balmaseda, A., Boyd, S. D., Harris, E., & Fire, A. Z. (2013). Convergent Antibody Signatures in Human Dengue. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2013.05.008
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