The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Loop-Mediated Isothermal PCR (LAMP) for the Diagnosis of Falciparum Malaria
Abstract
A recently described loop-mediated isothermal polymerase chain reaction (LAMP) for molecular detection of Plasmodium falciparum was compared with microscopy, PfHRP2-based rapid diagnostic test (RDT), and nested polymerase chain reaction (PCR) as the “gold standard” in 115 Bangladeshi in-patients with fever. DNA extraction for LAMP was conducted by conventional methods or simple heating of the sample; test results were either assessed visually or by gel electrophoresis. Conventional DNA extraction followed by gel electrophoresis had the highest agreement with the reference method (81.7%, κ = 0.64), with a sensitivity (95% CI) of 76.1% (68.3–83.9%), comparable to RDT and microscopy, but a specificity of 89.6% (84.0–95.2%) compared with 100% for RDT and microscopy. DNA extraction by heat treatment deteriorated specificity to unacceptable levels. LAMP enables molecular diagnosis of falciparum malaria in settings with limited technical resources but will need further optimization. The results are in contrast with a higher accuracy reported in an earlier study comparing LAMP with a non-validated PCR method.
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“Several studies that compared the LAMP method to microscopy, PCR and RDT, reported high sensitivity and specificity compared with microscopy or PCR in nonpregnant populations [34–37].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [35]
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Metadata
- Authors
- Paris, D. H., Imwong, M., Faiz, A. M., Hasan, M., Yunus, E. B., Silamut, K., Lee, S. J., Day, N. P. J., & Dondorp, A. M.
- Affiliations
- Mahidol University (TH)
- Corresponding author
- Paris, Daniel H.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2007-11
- Volume
- 77
- Issue
- 5
- Pages
- 972-976
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W1888003576
- Cited by
- 132
- References
- 19
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 9 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 18 · 2014: 11 · 2013: 12 · 2012: 12
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Keywords
- falciparum malaria, molecular diagnosis, microscopic diagnosis, nested PCR, diagnostic accuracy, DNA extraction, resource-limited settings
- MeSH terms
- Bangladesh, Humans, Microscopy, Sensitivity and Specificity, Polymerase Chain Reaction, Malaria, Falciparum
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