Comparative Diagnosis of Malaria Infections by Microscopy, Nested PCR, and LAMP in Northern Thailand

Pöschl, Birgit; Waneesorn, Jarurin; Thekisoe, Oriel; Chutipongvivate, Salakchit; Panagiotis, Karanis

doi:10.4269/ajtmh.2010.09-0630

Cited by 94Malaria Research and ControlBiosensors and Analytical DetectionBacterial Identification and Susceptibility Testing

Comparative Diagnosis of Malaria Infections by Microscopy, Nested PCR, and LAMP in Northern Thailand

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Pöschl, Birgit, Waneesorn, Jarurin, Thekisoe, Oriel, Chutipongvivate, Salakchit, Panagiotis, Karanis·2010·The American Society of Tropical Medicine and Hygiene

DOI 10.4269/ajtmh.2010.09-0630PMC PMC2912576

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Abstract

Three methods, microscopy, nested polymerase chain reaction (nPCR), and loop-mediated isothermal amplification (LAMP) have been applied for malaria diagnosis in 105 human blood samples collected in Northern Thailand. Only Plasmodium falciparum and Plasmodium vivax infections were detected. A total number of 57 positives (54%) could be detected for P. falciparum and 25 (24%) for P. vivax when all samples that were positive in any of the three methods are counted together. The nPCR was used as a reference standard for comparison with the other methods, microscopy and LAMP. The sensitivity of LAMP for P. falciparum was 100%. All nPCR-negative samples for P. falciparum were also negative by both microscopy and LAMP (specificity, 100%). For diagnosis of P. vivax , microscopy detected 15 of 23 nPCR-positive samples (sensitivity, 65%). LAMP detected 22 of 23 nPCR-positives (sensitivity, 96%). Among the 82 nPCR-negative samples microscopy detected two samples (specificity, 98%). All 82 nPCR-negative were also negative by the LAMP method (specificity, 100%). Both Plasmodium genus- and species-specific LAMP primer sets yielded the same results in all samples. There were no significant differences in the prevalence detected by each method. We assume that LAMP was as reliable as nPCR and more reliable than microscopy in the detection of Plasmodium DNA tested in the examined Thai field blood samples. This study further validates LAMP as an alternative molecular diagnostic tool, which can be used in the diagnosis of early infections of malaria cases and together with nPCR can also be used as supplementary methods for clinical and epidemiological use.

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Several studies reported high sensitivity and specificity of LAMP compared with microscopy or PCR in nonpregnant populations.
“Several studies that compared the LAMP method to microscopy, PCR and RDT, reported high sensitivity and specificity compared with microscopy or PCR in nonpregnant populations [34–37].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [37]

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MALARIA DIAGNOSIS BY LOOP-MEDIATED ISOTHERMAL AMPLIFICATION (LAMP) IN THAILAND
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Authors: Pöschl, B., Waneesorn, J., Thekisoe, O., Chutipongvivate, S., & Panagiotis, K.
Affiliations: University of Cologne (DE)
ORCID: Waneesorn, Jarurin
Thekisoe, Oriel
Venue: The American Society of Tropical Medicine and Hygiene
Publisher: American Society of Tropical Medicine and Hygiene
Published: 2010-07
Volume: 83
Issue: 1
Pages: 56-60
ISSN: 0002-9637 (ISSN-L)
1476-1645
DOI: 10.4269/ajtmh.2010.09-0630
PMC: PMC2912576
OpenAlex: W2104196075
Cited by: 94
References: 29
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 9 · 2016: 1 · 2015: 7 · 2014: 12 · 2013: 11 · 2012: 10
FWCI: 8.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Tropical Medicine and Hygiene (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
Keywords: malaria diagnosis, loop-mediated isothermal amplification, nested PCR, microscopy, Plasmodium falciparum, Plasmodium vivax, sensitivity and specificity, molecular diagnosis, northern Thailand
MeSH terms: DNA, Mitochondrial, DNA, Ribosomal, Humans, Malaria, Microscopy, Molecular Sequence Data, Plasmodium falciparum, Sensitivity and Specificity, Species Specificity, Thailand, Prevalence, DNA, Protozoan, Polymerase Chain Reaction, Malaria, Falciparum, Sequence Analysis, DNA, Nucleic Acid Amplification Techniques, Pathology, Molecular

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Comparative Diagnosis of Malaria Infections by Microscopy, Nested PCR, and LAMP in Northern Thailand

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