The DOI matches its Crossref record, with a small difference in title or year; 13 of the 13 references it cites were found in a registry or an index.
An Alternative Route of Treatment in Transient Hypothyroxinemia of Prematurity: Rectal Administration of Levothyroxine
Open accessAbstract
Parallel to the improved survival of more immature preterm babies, studies concerning THOP have also increased.Conflicting results have been reported considering neurodevelopmental, auditory and cognitive outcomes of very low birth weight babies with or without THOP, some showing no significant difference between the two groups (5).Reports on the effect of treatment of THOP on neurodevelopmental outcome in preterm babies are also AbstractTransient hypothyroxinaemia of prematurity (THOP) is a disorder encountered particularly in extremely low birth weight and preterm newborns.In recent years, the survival rates of these babies have increased, owing to the advances in neonatal care, thereby increasing the incidence of THOP.Controversies about the management of this disorder still continues while accompanying morbidites may create difficulties in the treatment of these patients.A preterm baby boy, born at 25 6/7 gestational weeks with a birthweight of 665 g who developed short bowel syndrome after necrotizing enterocolitis surgery and who was treated with rectal levothyroxine, is presented.
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Some patients with short bowel syndrome were reported to be refractory to oral LT4.
“Some patients with short bowel syndrome were reported to be refractory to oral LT4, and alternative routes, such as rectal administration or SC injection, were recommended (24, 53).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [53]
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Leemhuis, A. G., Kok, J. H., de Vijlder, J. J. M., Briët, J. M., Smit, B. J., Tamminga, P., van Baar, A. L., Dekker, F. W., & Vulsma, T. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701023360104 · Cited by 292
Developmental Trends in Cord and Postpartum Serum Thyroid Hormones in Preterm Infants
Williams, F. L. R., Simpson, J., Delahunty, C., Ogston, S. A., Bongers‐Schokking, J. J., Murphy, N., van Toor, H., Wu, S.-Y., Visser, T. J., & Hume, R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0869 · Cited by 186
Reference ranges for newer thyroid function tests in premature infants
Adams, L. M., Emery, J. R., Clark, S. J., Carlton, E. I., & Nelson, J. C. (1995) · The Journal of Pediatrics · doi:10.1016/s0022-3476(95)70514-7 · Cited by 123
Trials with Thyroid Hormone in Preterm Infants: Clinical and Neurodevelopmental Effects
Leemhuis, A. G., & Kok, J. H. (2008) · Seminars in Perinatology · doi:10.1053/j.semperi.2008.09.008 · Cited by 36
Current knowledge of transient hypothyroxinemia of prematurity: to treat or not to treat?
Iijima, S. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1441277 · Cited by 31
Ng, S. M., Turner, M. A., & Weindling, A. M. (2020) · Thyroid · doi:10.1089/thy.2019.0293 · Cited by 24
Clinical efficacy and pharmacokinetics of levothyroxine suppository in patients with hypothyroidism
Kashiwagura, Y., Uchida, S., Tanaka, S., Watanabe, H., Masuzawa, M., Sasaki, T., & Namiki, N. (2014) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00998 · Cited by 18
Alternative routes of levothyroxine administration for hypothyroidism
Ritter, M. J., Gupta, S., & Hennessey, J. V. (2020) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000558 · Cited by 18
Tan, L. O., Tan, M. G., & Poon, W. B. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222018 · Cited by 18
Eerdekens, A., Langouche, L., den Berghe, G. V., Verhaeghe, J., Naulaers, G., & Vanhole, C. (2018) · Acta Paediatrica · doi:10.1111/apa.14685 · Cited by 17
Yoon, S. A., Chang, Y. S., Ahn, S. Y., Sung, S. I., & Park, W. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-46108-9 · Cited by 14
Obeidat, K. A., Saadeh, N. A., As\'ad, A., & Bakkar, S. (2018) · American Journal of Case Reports · doi:10.12659/ajcr.909437 · Cited by 12
Rectal levothyroxine for the treatment of hypothyroidism: a case study
Ybarra, M., dos Santos, T. J., Pinheiro, C. T. C., Dichtchekenian, V., & Damiani, D. (2018) · PEDIATRICS · doi:10.1542/peds.2017-3317 · Cited by 10
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Levothyroxine: conventional and novel drug delivery formulations.
Liu, H., Li, W., Zhang, W., Sun, S., & Chen, C. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnac030 · Cited by 63
Side effects of thyroid hormones, iodine, iodides, and antithyroid medications
Damanakis, E., Shor, A., & Ray, S. D. (2024) · Side effects of drugs annual · doi:10.1016/bs.seda.2024.08.011
Tablets for insertion into body cavities
Kumar, L., Pandav, G., & Jana, P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36751-9.00015-2
Metadata
- Authors
- Tunçel, D., İnce, Z., Aygün, E., & Çoban, A.
- Affiliations
- Istanbul University (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Corresponding author
- Tunçel, Duygu
- Venue
- Journal of Clinical Research in Pediatric Endocrinology
- Publisher
- Galenos Yayinevi
- Published
- 2023-05-29
- Volume
- 15
- Issue
- 2
- Pages
- 220-224
- ISSN
- 1308-5727 (ISSN-L)
- 1308-5735
- PMC
- PMC10234050
- OpenAlex
- W3203068505
- Cited by
- 3
- References
- 13
- Citations by year
- 2026: 1 · 2024: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Journal of Clinical Research in Pediatric Endocrinology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- preterm infants, extremely low birth weight, short bowel syndrome, necrotizing enterocolitis
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