Assessment of commercially safflower oils (Carthami Oleum Raffinatum) in terms of European Pharmacopoeia Criteria and their weight control potentials
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Objectives: weight control potential of all samples was investigated. Materials and Methods: Samples to be analyzed were purchased from pharmacies, herbal, online, and cosmetics stores. Acid and peroxide values of 11 safflower samples and analysis of their fatty acids by gas chromatography-mass spectrometry (GC-MS) were carried out according to the "Carthami oleum raffinatum" monograph registered in the European Pharmacopeia 7.0. To test the effects of all samples on weight control, their inhibitory effects on carbohydrate-digesting enzymes (α-glucosidase and α-amylase) were evaluated using spectrophotometric methods. Results: Out of 11 oil samples, only two of them had acid and peroxide values below the reference value. According to GC analysis, safflower oil samples are rich in monounsaturated fatty acids (oleic acid) and polyunsaturated fatty acids (linoleic acid) (67.10-99.53%) of total fatty acids in its content are oleic, linoleic, palmitic, and stearic acids. Saturated fatty acids were 0.58 to 12.18% of the total fatty acid methyl esters in oils. When evaluated in terms of the inhibition of α-amylase and α-glucosidase enzymes that hydrolyze carbohydrates, the results showed that safflower oil samples had no inhibitory activity on these enzymes. Conclusion: It has been determined in this report that many safflower oil samples on the market do not meet the quality criteria recommended in European Pharmacopoeia 7.0. It was observed that safflower oil did not show any inhibitory effect on these two enzymes, which is considered a rational approach for weight control.
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Nearly all almond and safflower oil samples from the Turkish market were reported to lack quality according to EP criteria.
“Nearly all of the almond and safflower oil samples from the Turkish market were reported as lacking quality in terms of EP criteria.11,12”
From Evaluation of Marketed Rosemary Essential Oils (<i>Rosmarinus officinalis</i> L.) in Terms of European Pharmacopoeia 10.0 Criteria (2023) · cites this paper as [12]
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Ali, H. K., Houghton, P., & Soumyanath, A. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.04.004 · Cited by 867 · see citing works
Zhou, X., Tang, L., Xu, Y.-L., et al. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.10.050 · Cited by 237 · see citing works
Khalid, N., Khan, R. S., Hussain, M. I., Farooq, M., Ahmad, A., & Ahmed, I. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.06.009 · Cited by 203 · see citing works
Wang, Y., Chen, P., Tang, C., Wang, Y., Li, Y., & Zhang, H. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.12.003 · Cited by 159 · see citing works
Extraction of safflower seed oil by supercritical CO2
Han, X., Cheng, L., Zhang, R., et al. (2008) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2008.12.002 · Cited by 154 · see citing works
Safflower (Carthamus tinctorius L.) the Underutilized and Neglected Crop: A Review
Emongor, V. E. (2010) · Asian Journal of Plant Sciences · doi:10.3923/ajps.2010.299.306 · Cited by 122 · see citing works
α-Glucosidase inhibitors from the seeds of Syagrus romanzoffiana
Lam, S.-H., Chen, J., Kang, C.-J., Chen, C.-H., & Lee, S. (2008) · Phytochemistry · doi:10.1016/j.phytochem.2007.12.004 · Cited by 112 · see citing works
Inhibitory potential of fatty acids on key enzymes related to type 2 diabetes
Su, C., Hsu, C., & Ng, L. (2013) · BioFactors · doi:10.1002/biof.1082 · Cited by 100 · see citing works
Potent α‐Glucosidase Inhibitors from Safflower (Carthamus tinctorius L.) Seed
Takahashi, T., & Miyazawa, M. (2012) · Phytotherapy Research · doi:10.1002/ptr.3622 · Cited by 59 · see citing works
Oil extraction from enriched Spirulina platensis microalgae using supercritical carbon dioxide
Crampon, C., Nikitine, C., Zaier, M., Lépine, O., Tanzi, C. D., Vian, M. A., Chemat, F., & Badens, E. (2017) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2016.10.006 · Cited by 58 · see citing works
Konopka, I., Roszkowska, B., Czaplicki, S., & Tańska, M. (2016) · Food Technology and Biotechnology · doi:10.17113/ftb.54.04.16.4623 · Cited by 51 · see citing works
Mendes-da-Silva, R. F., Ferreira, D. J. S., Morais, A., de Macêdo, P. F. C., Lagranha, C. J., & Hornsby, M. B.-D.-O. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1360549 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 8
- Kıllı F, Beycioğlu T. Oil seeds and crude oil production in the World and Turkey, problems of oilseeds production in Turkey. IJAAES. 2019;1:17-33.
- Gautam S, Bhagyawant SS, Srivastava N. Detailed study on therapeutic properties, uses and pharmacological applications of safflower (Carthamus tinctorius L.). Int J Ayur Pharma Res. 2014;2:1-4.
- EU. European pharmacopeia 7 th edition. In: Healthcare EDftQoMa (ed). Vol 1. Germany, Druckerei C.H. Beck Press, 2011;1346.
- EU. European pharmacopeia 8 th edition. In: Healthcare EDftQoMa (ed). Vol a. Germany, Druckerei C.H. Beck Press, 2014;155.
- Davis PH. Flora of Turkey and The East Aegeans Islands (vol. 5). Edinburgh England; The University Press; 1975.
- Rashmi Dehariya AKD. A review on potential pharmacological uses of Carthamus tinctorius L. World J Pharm Sci. 2015;3:1741-1747.
- Safflower. Smith JR. Taylor & Francis, 1996.
- Arslan Y, Katar D, Güneylioğlu H, Subaşı İ, Şahin B, Bülbül AS. Arslan Y, Katar D, Güneylioğlu H, Subaşı İ, Şahin B, Bülbül AS. The wild species of Carthamus L. in natural flora of Turkey and possibilities of using safflower breeding. J Central Res Inst Field Crops. 2010;19:36-43.
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BARAK, T. H., BÖLÜKBAŞ, E., & BARDAKCI, H. (2023) · Turkish Journal of Pharmaceutical Sciences · doi:10.4274/tjps.galenos.2022.78010 · Cited by 29 · see citing works
- Authors
- DELİORMAN ORHAN, D., PEKACAR, S., ULUTAŞ, O. K., ÖZÜPEK, B., SÜMMEOĞLU, D., & BERKKAN, A.
- Affiliations
- Gazi University (TR)
- ORCID
- Venue
- Turkish Journal of Pharmaceutical Sciences
- Publisher
- Galenos Yayinevi
- Published
- 2022-06-27
- Volume
- 19
- Issue
- 3
- Pages
- 273-279
- ISSN
- 1304-530X (ISSN-L)
- 2148-6247
- PMC
- PMC9254086
- OpenAlex
- W3195462579
- Cited by
- 14
- References
- 12
- Citations by year
- 2026: 5 · 2024: 6 · 2023: 2 · 2022: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Turkish Journal of Pharmaceutical Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Sunflower and Safflower Cultivation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Keywords
- safflower oil, weight management, European Pharmacopoeia monograph, fatty acid composition, oleic acid, linoleic acid, acid value, peroxide value, α-glucosidase inhibition, α-amylase inhibition, carbohydrate-digesting enzymes
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