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Nanoparticles - A review
Open accessAbstract
For the past few decades, there has been a considerable research interest in the area of drug delivery using particulate delivery systems as carriers for small and large molecules. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. They have been used in vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to the site of action. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. Here, we review various aspects of nanoparticle formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules and therapeutic genes. Keywords: nanoparticles, drug delivery, targeting, drug release > Tropical Journal of Pharmaceutical Research Vol. 5 (1) 2006: pp. 561-573
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The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent
Desai, M. P., Labhasetwar, V., Walter, E., Levy, R. J., & Amidon, G. L. (1997) · Pharmaceutical Research · doi:10.1023/a:1012126301290 · Cited by 858
Defining the drug incorporation properties of PLA–PEG nanoparticles
Govender, T. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00375-6 · Cited by 225
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Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Ratiometric optical nanoprobes enable accurate molecular detection and imaging
Huang, X., Song, J., Yung, B. C., Huang, X., Xiong, Y., & Chen, X. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00612h · Cited by 820
Vanlalveni, C., Lallianrawna, S., Biswas, A., Selvaraj, M., Changmai, B., & Rokhum, S. L. (2021) · RSC Advances · doi:10.1039/d0ra09941d · Cited by 804
Polyhydroxyalkanoates: Characteristics, production, recent developments and applications
Raza, Z. A., Abid, S., & Banat, I. M. (2018) · International Biodeterioration & Biodegradation · doi:10.1016/j.ibiod.2017.10.001 · Cited by 708
Mahapatro, A., & Singh, D. K. (2011) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-9-55 · Cited by 685
Metadata
- Authors
- Mohanraj, V. J., & Chen, Y.
- Venue
- Tropical Journal of Pharmaceutical Research
- Publisher
- African Journals Online (AJOL)
- Published
- 2007-07-31
- Volume
- 5
- Issue
- 1
- ISSN
- 1596-5996 (ISSN-L)
- 1596-9827
- OpenAlex
- W2138281910
- Cited by
- 1,217
- References
- 2
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- gold
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