Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca2+signaling pathway
Open accessAbstract
Mobilization of intracellular Ca(2+) stores is involved in many diverse cell functions, including: cell proliferation; differentiation; fertilization; muscle contraction; secretion of neurotransmitters, hormones and enzymes; and lymphocyte activation and proliferation. Cyclic adenosine diphosphate ribose (cADPR) is an endogenous Ca(2+) mobilizing nucleotide present in many cell types and species, from plants to animals. cADPR is formed by ADP-ribosyl cyclases from nicotinamide adenine dinucleotide. The main ADP-ribosyl cyclase in mammals is CD38, a multi-functional enzyme and a type II membrane protein. It has been shown that many extracellular stimuli can induce cADPR production that leads to calcium release or influx, establishing cADPR as a second messenger. cADPR has been linked to a wide variety of cellular processes, but the molecular mechanisms regarding cADPR signaling remain elusive. The aim of this review is to summarize the CD38/cADPR/Ca(2+) signaling pathway, focusing on the recent advances involving the mechanism and physiological functions of cADPR-mediated Ca(2+) mobilization.
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CD38 influences cellular processes and immune responses by producing secondary messenger NAD metabolites, including cADPR and NaADP, to control Ca2+ mobilization and cell migration.
“Another mechanism by which CD38 may influence cellular processes and immune responses is by the production of secondary messenger NAD metabolites, including cADPR and NaADP, to control Ca2+ mobilization and cell migration67.”
From Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages (2020) · cites this paper as [67]
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- Deshpande DA, Walseth TF, Panettieri RA, Kannan MS. CD38/cyclic ADP-ribose-mediated Ca2+ signaling contrib- utes to airway smooth muscle hyper-responsiveness. FASEB J 2003; 17: 452-454 [PMID: 12514117]
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- Authors
- Wei, W.
- Affiliations
- University of Hong Kong (HK)
- Corresponding author
- Wei, Wenjie
- ORCID
- Wei, Wenjie
- Venue
- World Journal of Biological Chemistry
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 5
- Issue
- 1
- Pages
- 58
- ISSN
- 1949-8454 (ISSN-L)
- PMC
- PMC3942542
- OpenAlex
- W1989881684
- Cited by
- 89
- References
- 91
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 14 · 2020: 9 · 2019: 11 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 8 · 2014: 2
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Biological Chemistry (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- CD38, cyclic ADP-ribose, calcium signaling, calcium mobilization, ADP-ribosyl cyclase, second messengers, intracellular calcium stores, lymphocyte activation, type II membrane protein
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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