Comparative Study of Kefir Yogurt-Drink and Sodium Fluoride Mouth Rinse on Salivary Mutans Streptococci
Open accessAbstract
Aim: The level of mutans streptococci (MS) is reduced by regularly consumption of probiotic Kefir drink. The present study aiming at answer to this question ‘may the Kefir drink be considered an alternative to fluoride rinse?’ Materials and Methods: Twenty-two healthy volunteers aged 22-32 years with good oral hygiene participated in this study. None of participants had received any antibiotic or antimicrobial agent or professional fluoride therapy within the last month. None of them exhibited active caries lesions. Smokers and subjects who have chewing gums xylitol habit or who were undergoing orthodontic treatment were excluded. In a cross over design with 2 parallel groups, people in group A for 2 weeks received 100 ml of Kefir drink per day, then avoided brushing, eating and drinking for an hour. Simultaneously, people in group B were administered 0.05% sodium fluoride rinse in the same manner. After washout period, people in groups A and B respectively used 0.05% sodium fluoride rinse and Kefir drink. Saliva sampling was performed before and after interventions. The acidity and the count of MS were assessed and data were analyzed statistically. Result: There was no significant difference between base line pH values of saliva in study groups (p > 0.05). Although, a significant difference was shown between MS counts before and after interventions (p . 0.0001 and p . 0.0001 for NaF and Kefir respectively), but the equal inhibitory effect was found between study groups (p > 0.05). Conclusion: Kefir drink can inhibit salivary MS as well the sodium fluoride rinse. This beverage may be considered an alternative for fluoride rinse. Clinical significance: Probiotics containing dairy products was known with anticariogenic properties. These agents may be used in caries control strategies adjunctively. How to cite this article: Ghasempour M, Sefidgar SAA, Moghadamnia AA, Ghadimi R, Gharekhani S, Shirkhani L. Comparative Study of Kefir Yogurt-Drink and Sodium Fluoride Mouth Rinse on Salivary Mutans Streptococci. J Contemp Dent Pract 2014;15(2):214-217.
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Cites
Bergey's Manual of Systematic Bacteriology
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-391_3 · Cited by 15,633 · see citing works
Dentistry for the Child and Adolescent
McDonald, E. B. R. E., Avery, D. R., & Dean, J. A. (1974) · Cited by 628 · see citing works
Demineralization and remineralization around orthodontic appliances: An in vivo study
O'Reilly, M., & Featherstone, J. D. B. (1987) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/0889-5406(87)90293-9 · Cited by 621 · see citing works
The Microbiology of Primary Dental Caries in Humans
Tanzer, J. M., Livingston, J., & Thompson, A. M. (2001) · Journal of Dental Education · doi:10.1002/j.0022-0337.2001.65.10.tb03446.x · Cited by 594 · see citing works
Kefir: a probiotic dairy-composition, nutritional and therapeutic aspects
., S. O., & ., O. C. (2003) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2003.54.59 · Cited by 325 · see citing works
Ecology of Lactobacilli in the Oral Cavity: A Review of Literature
Badet, C., & Thébaud, N. (2008) · The Open Microbiology Journal · doi:10.2174/1874285800802010038 · Cited by 244 · see citing works
Çağlar, E., Kavaloglu, S. C., Kuşcu, Ö. Ö., Sandallı, N., Holgerson, P. L., & Twetman, S. H. A. (2007) · Clinical Oral Investigations · doi:10.1007/s00784-007-0129-9 · Cited by 195 · see citing works
Probiotics and oral health effects in children
Twetman, S. H. A., & STECKSÉN‐BLICKS, C. (2007) · International Journal of Paediatric Dentistry · doi:10.1111/j.1365-263x.2007.00885.x · Cited by 160 · see citing works
Lactobacillus‐mediated interference of mutans streptococci in caries‐free vs. caries‐active subjects
Simark‐Mattsson, C., Emilson, C. G., Håkansson, E. G., Jacobsson, C., Roos, K., & Holm, S. E. (2007) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2007.00458.x · Cited by 144 · see citing works
Montalto, M., Vastola, M. E., Marigo, L., Covino, M., Graziosetto, R., Curigliano, V., Santoro, L., Cuoco, L., Manna, R., & Gasbarrini, A. (2004) · Digestion · doi:10.1159/000076559 · Cited by 141 · see citing works
Probiotics for oral health: myth or reality?
Bonifait, L., Chandad, F., & Grenier, D. (2009) · PubMed · Cited by 133 · see citing works
Petersson, L. G., Magnusson, K., Hakestam, U., Baigi, A., & Twetman, S. H. A. (2011) · Acta Odontologica Scandinavica · doi:10.3109/00016357.2011.568962 · Cited by 103 · see citing works
Effectiveness of a caries preventive program in pregnant women and new mothers on their offspring
Gomez, S. S., & Weber, A. A. (2001) · International Journal of Paediatric Dentistry · doi:10.1046/j.1365-263x.2001.00255.x · Cited by 91 · see citing works
Acid Production from Sugars and Sugar Alcohols by Probiotic Lactobacilli and Bifidobacteria in vitro
Haukioja, A. L., Söderling, E. M., & Tenovuo, J. O. (2008) · Caries Research · doi:10.1159/000163020 · Cited by 86 · see citing works
Tahmourespour, A., Salehi, R., Kermanshahi, R. K., & Eslami, G. (2011) · Biofouling · doi:10.1080/08927014.2011.575458 · Cited by 70 · see citing works
Tahmourespour, A., & Kermanshahi, R. K. (2011) · Biomolecules and Biomedicine · doi:10.17305/bjbms.2011.2621 · Cited by 64 · see citing works
Probiotics--do they have a role in medicine and dentistry?
Saraf, K., Shashikanth, M., Priy, T., Sultana, N., & Chaitanya, N. C. (2010) · PubMed · Cited by 58 · see citing works
Achieving Probiotic Effects <i>via</i> Modulating Oral Microbial Ecology
He, X., Lux, R., Kuramitsu, H. K., Anderson, M. H., & Shi, W. (2009) · Advances in Dental Research · doi:10.1177/0895937409335626 · Cited by 52 · see citing works
Antimicrobial effect of fluoride mouthrinse on mutans streptococci and lactobacilli in saliva.
Yoshihara, A., Sakuma, S., Kobayashi, S., & Miyazaki, H. (2001) · PubMed · Cited by 47 · see citing works
STECKSÉN‐BLICKS, C., Holgerson, P. L., & Twetman, S. (2008) · International Journal of Paediatric Dentistry · doi:10.1111/j.1365-263x.2007.00912.x · Cited by 37 · see citing works
Çoğulu, D., Ak, A. T., Çağlar, E., Sandallı, N., Karagözlü, C., Ersin, N. K., & Yerlıkaya, O. (2010) · Journal of Dental Sciences · doi:10.1016/s1991-7902(10)60021-9 · Cited by 35 · see citing works
The role of fluoride mouthrinses in the control of dental caries: a brief review.
Sm, A. (1998) · PubMed · Cited by 23 · see citing works
Evaluation of clinical and microbiological features of deep carious lesions in primary molars.
Ayna, B. E., Çelenk, S., Atakul, F., Sezgin, B., & Özekinci, T. (2003) · PubMed · Cited by 17 · see citing works
Probiotics, Critical Illness, and Methodologic Bias
Koretz, R. L. (2009) · Nutrition in Clinical Practice · doi:10.1177/0884533608329296 · Cited by 16 · see citing works
Influence of a Fluoride Mouthrinse on Mutans Streptococci in Schoolchildren
Kaneko, N., Yoshihara, A., Ida, H., Nomura, Y., Imai, S., Nisizawa, T., Sakuma, S., Hanada, N., & Miyazaki, H. (2006) · Caries Research · doi:10.1159/000095649 · Cited by 15 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Sundas S, Rao A. Comprative evaluation of chlorhexidine and sodium fluoride mouthwashes on streptococcus mutans. J Nepal Dent Assoc 2011;12(1):17-21.
- Agarwal E, Bajaj P, Guruprasad CN, Naik S, Pradeep AR. Probiotics: a novel step towards oral health. AOSR 2011; 1(2):108-115.
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Rosa, D. D., Dias, M. M. S., Grześkowiak, Ł. M., Reis, S. A., Conceição, L. L., & Peluzio, M. D. C. G. (2017) · Nutrition Research Reviews · doi:10.1017/s0954422416000275 · Cited by 463 · see citing works
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Rad, A. H., Pourjafar, H., & Mirzakhani, E. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1120995 · Cited by 200 · see citing works
Nadelman, P., Magno, M., Masterson, D., da Cruz, A. D., & Maia, L. (2018) · Clinical Oral Investigations · doi:10.1007/s00784-018-2682-9 · Cited by 66 · see citing works
Devasya, A. (2015) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2015/10942.5532 · Cited by 62 · see citing works
da Cruz, M. F., Magno, M. B., Jural, L. A., Pimentel, T. C., Ferreira, D. M. T. P., Esmerino, E. A., Ramos, G. L. D. P. A., Gomila, J. V., Silva, M. C., da Cruz, A. G., et al. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111228 · Cited by 57 · see citing works
Javid, A. Z., Amerian, E., Basir, L., Ekrami, A., Haghighizadeh, M. H., & Maghsoumi‐Norouzabad, L. (2019) · Caries Research · doi:10.1159/000504164 · Cited by 54 · see citing works
Alp, S., & Baka, Z. M. (2018) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2018.01.010 · Cited by 50 · see citing works
Kairey, L., Leech, B., El‐Assaad, F., Bugarc̀ić, A., Dawson, D. E., & Lauche, R. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac054 · Cited by 28 · see citing works
Pietri, F., Rossouw, P. E., Javed, F., & Michelogiannakis, D. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-020-09683-2 · Cited by 24 · see citing works
Mahantesha, T., Reddy, K. P., Kumar, N. H. P., Nara, A., Devasya, A., & Buddiga, V. (2015) · PubMed Central · Cited by 23 · see citing works
Patil, R., Dastoor, P., & Unde, M. (2019) · Journal of Indian Society of Pedodontics and Preventive Dentistry · doi:10.4103/jisppd.jisppd_45_19 · Cited by 20 · see citing works
Afshari, E., Haghgoo, R., Ghanaat, T., & Aghazadeh, S. (2015) · Journal of International Society of Preventive and Community Dentistry · doi:10.4103/2231-0762.172947 · Cited by 20 · see citing works
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Bessa, M. K., Bessa, G. R., & Bonamigo, R. R. (2023) · Nutrition Research Reviews · doi:10.1017/s0954422423000070 · Cited by 15 · see citing works
Gedam, K. Y., & Katre, A. N. (2022) · Lifestyle Genomics · doi:10.1159/000519916 · Cited by 14 · see citing works
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Kefir Consumption and Health Effects Based on Human Clinical Trials: An Overview of Literature
Fijan, S., Povalej, P., Pogačar, M. Š., & Klanjšek, P. (2026) · Healthcare · doi:10.3390/healthcare14050652 · Cited by 7 · see citing works
Parker, E., Gossard, C. M., Dolan, K. E., Finley, H. J., Burns, C. M., Gasta, M. G., Pizano, J. M., Williamson, C. B., & Lipski, E. A. (2016) · Europe PMC (PubMed Central) · Cited by 6 · see citing works
The Effect of Probiotics on Oral Health
Nadelman, P., Magno, M. B., da Cruz, M. F., da Cruz, A. G., Pithon, M. M., Fonseca‐Gonçalves, A., & Maia, L. C. (2020) · Wiley eBooks · doi:10.1002/9781119618973.ch12 · Cited by 3 · see citing works
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Murwani, S. (2017) · American Journal of Animal and Veterinary Sciences · doi:10.3844/ajavsp.2017.53.57 · Cited by 2 · see citing works
Keyfi Adında Olan İçecek: Kefirin Diş Hekimliğindeki Yeri ve Periodontolojideki Geleceği
Şahin, T., & Özmeriç, N. (2021) · Hacettepe Üniversitesi Sağlık Bilimleri Fakültesi Dergisi · doi:10.21020/husbfd.815116 · Cited by 1 · see citing works
BILOURO, F. C., Rocha, R. S., Guimarães, J. T., Pimentel, T. C., Magnani, M., Esmerino, E. A., Freitas, M. Q., Silva, M. C., da Cruz, A. G., & Canabarro, A. (2022) · Food Science and Technology · doi:10.1590/fst.17922 · Cited by 1 · see citing works
González-Rascón, A. A., Chávez-Cortéz, E. G., Camarena, A. H., Serafín‐Higuera, N., Castillo-Uribe, S., Martínez-Aguilar, V. M., Carrillo-Ávila, B. A., & Pitones-Rubio, V. (2025) · Dentistry Journal · doi:10.3390/dj13020086 · Cited by 1 · see citing works
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- Authors
- Sefidgar, S. A. A., Moghadamnia, A. A., Ghadimi, R., & Shirkhani, L.
- Affiliations
- Babol University of Medical Sciences (IR)
- Venue
- The Journal of Contemporary Dental Practice
- Publisher
- Jaypee Brothers Medical Publishing
- Published
- 2014
- Volume
- 15
- Issue
- 2
- Pages
- 214-217
- ISSN
- 1526-3711 (ISSN-L)
- OpenAlex
- W2002423116
- Cited by
- 33
- References
- 25
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 3
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Contemporary Dental Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Keywords
- kefir, probiotics, mutans streptococci, salivary bacteria, dental caries prevention, anticariogenic effect, salivary pH, fluoride alternatives
- MeSH terms
- Adult, Cariostatic Agents, Female, Food Handling, Humans, Male, Mouthwashes, Saliva, Sodium Fluoride, Streptococcus mutans, Cross-Over Studies, Probiotics, Cultured Milk Products, Young Adult, Bacterial Load
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