Use of prucalopride for chronic constipation: a systematic review and meta-analysis of published randomized, controlled trials
Open accessAbstract
This article highlights the role of prucalopride in the management of chronic constipation based upon the principles of meta-analysis using data reported in the published randomized, controlled trials. Sixteen randomized, controlled trials on 3943 patients reported the effectiveness of prucalopride in patients with chronic constipation. Prucalopride successfully increased the frequency of spontaneous bowel movements per week in all variable doses of 1 mg (standardized mean difference [SMD], 0.42 [95% CI, 0.18-0.66; P = 0.006]), 2 mg (SMD, 0.34 [95% CI, 0.11-0.56; P = 0.003]), and 4 mg (SMD, 0.33 [95% CI, 0.22-0.44; P = 0.00001]). The risks of adverse events or side effects such as headache, abdominal cramps, excessive flatulence, dizziness, diarrhea, and rash were higher (odds ratio, 1.70 [95% CI, 1.27 to -2.27; P = 0.0004]) in prucalopride group. Prucalopride is clinically a beneficial pharmacotherapy for chronic constipation and its routine use may be considered in patients with chronic simple laxative-resistant constipation.
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Prucalopride, a highly selective agonist for the serotonin 5-HT4 receptor, increases the number of bowel movements per week in adults with chronic functional constipation.
“For example, prucalopride, a highly selective agonist for serotonin 5-HT4 receptor, increases the number of bowel movements per week in adults with chronic FC [ 64 ].”
From Role of gut microbiota in functional constipation (2021) · cites this paper as [64]
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- Authors
- Sajid, M. S., Hebbar, M., Baig, M. K., Li, A., & Philipose, Z.
- Affiliations
- Worthing Hospital (GB)
- National Health Service (GB)
- Corresponding author
- Sajid, Muhammad S
- Venue
- Journal of Neurogastroenterology and Motility
- Published
- 2016-06-28
- Volume
- 22
- Issue
- 3
- Pages
- 412-422
- ISSN
- 2093-0879 (ISSN-L)
- 2093-0887
- PMC
- PMC4930296
- OpenAlex
- W2343386012
- Cited by
- 65
- References
- 70
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 2 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of Neurogastroenterology and Motility (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- prucalopride, chronic constipation, stool frequency, adverse events, drug efficacy, serotonin receptor agonists, pharmacotherapy
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