Wound healing is promoted by Musa paradisiaca (banana) extract in diabetic rats
Open accessAbstract
Introduction: Impairments in wound healing commonly occur among patients with diabetes. Herbal medicines have a long history of usage in wound care management. Super green (SG) is a newly discovered natural product obtained from Musa paradisiaca. This study aimed to investigate the efficacy of the topical application of SG in healing surgical wounds in diabetic rats. Material and methods: Wistar rats received a one-time intraperitoneal injection of streptozotocin to induce type 1 diabetes. Full-thickness excisional skin wounds were created on the backs of the rats. The relevant groups were topically treated with the indicated concentrations of SG or vehicle dressing throughout the study duration. Histological analysis was performed and the mRNA levels of proinflammatory cytokines were measured to evaluate the improvement of wound closure. Results: The wound area ratio of the SG (1/6000 dilution)-treated group was greatly reduced compared to that of the vehicle-treated group. The histological analysis showed fewer inflammatory cells, accelerated re-epithelialization, and increased collagen deposition in SG 1/6000-treated wounds. The gene expression levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 were decreased and the levels of type I and type III collagen were increased after SG treatment. Conclusions: These results show that the most therapeutically efficacious concentration of SG (1/6000 dilution) can enhance wound repair in diabetic rats. SG has the potential to be a new treatment strategy for diabetic wounds.
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Clinical and animal model studies indicate that banana peel extract has no side effects on human volunteers and in model animals except for mild burning sensation felt by some subjects.
“Its clinical and animal model studies indicate that this extract has no side effects on human volunteers and in model animals except for mild burning sensation felt by some subjects [3 - 5], therefore, offers eco-friendly product enrichment for cosmetic science.”
From Formulation development, physical stability, and preliminary safety screening of cosmetic emulsions containing banana peel extract (2026) · cites this paper as [5]
The Results section (page unavailable) says treated rat wounds appeared clean, without irritation or bleeding during the experiment. That supports a limited observation in rats, but the paper reports no human-volunteer study and does not document mild burning or establish an absence of all side effects. (LLM, conf=0.84)
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- Authors
- Cheng, Y.-Z., Liu, I.-M., Cheng, J.-T., Lin, B.-S., & Liu, F.
- Affiliations
- Chi Mei Medical Center (TW)
- Tajen University (TW)
- National Yang Ming Chiao Tung University (TW)
- Department of Research and Development, Natural Well Technical Company, Guishan, Taoyuan, Taiwan
- Corresponding author
- Cheng, Juei-Tang
- Venue
- Archives of Medical Science
- Publisher
- Termedia Sp. z.o.o.
- Published
- 2020-01-19
- Volume
- 20
- Issue
- 2
- Pages
- 632-640
- ISSN
- 1734-1922 (ISSN-L)
- 1896-9151
- PMC
- PMC11094818
- OpenAlex
- W3004367924
- Cited by
- 8
- References
- 44
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Archives of Medical Science (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
- Keywords
- wound healing, Musa paradisiaca, banana peel extract, diabetic wounds, type 1 diabetes, streptozotocin-induced diabetes, topical application, re-epithelialization, collagen deposition, inflammatory cytokines, TNF-α, IL-1β, interleukin-6, anti-inflammatory activity
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