Adrenopause – does it really exist?
Open accessAbstract
In ageing human adrenal glands there occur some morphological changes which result in alterations of their cortex endocrine function. Glucocorticoid-excreting cells in the zona glomerulosa live longer than androgen-producing cells in the zona reticularis, which undergo significant apoptosis. Therefore, in elderly humans cortisol levels are normal (significantly higher than at young age), while adrenal androgen concentrations decline with ageing. Function of the zona glomerulosa is affected by the adrenal status, circulatory system condition, efficiency of the kidneys and liver and medication. An important problem of ageing is the rising incidence of non-secreting, incidentally detected, benign adrenal tumors, called incidentalomas. They necessitate clear-sighted radiological and hormonal diagnosis.
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Adrenopause reaches minimum by age 70, with only about 5-10% of peak levels observed in young adulthood.
“This reaches a minimum by the age of 70, with only about 5–10% of the peak levels observed in young adulthood [46].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [46]
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“This reaches a minimum by the age of 70, with only about 5-10% of the peak levels observed in young adulthood [46].”
- Authors
- Papierska, L.
- Corresponding author
- Papierska, Lucyna
- ORCID
- Papierska, Lucyna
- Venue
- Menopausal Review
- Publisher
- Termedia Sp. z.o.o.
- Published
- 2017
- Volume
- 2
- Issue
- 2
- Pages
- 57-60
- ISSN
- 1643-8876 (ISSN-L)
- PMC
- PMC5509973
- OpenAlex
- W2725624115
- Cited by
- 8
- References
- 31
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 1
- FWCI
- 0.08
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Menopause Review/Przegląd Menopauzalny (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- adrenal cortex, zona glomerulosa, zona fasciculata, zona reticularis, apoptosis, cortisol, adrenal androgens, incidental adrenal tumor, adrenal incidentaloma, menopause
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