Activated microglial cells synthesize and secrete AGE-albumin
Open accessAbstract
A holy grail of curing neurodegenerative diseases is to identify the main causes and mechanisms underlying neuronal death. Many studies have sought to identify these targets in a wide variety of ways, but a more important task is to identify critical molecular targets and their origins. Potential molecular targets include advanced glycation end products (AGEs) that can promote neuronal cell death, thereby contributing to neurodegenerative disorders such as Alzheimer disease or Parkinson disease. In this study, we showed that AGE-albumin (glycated albumin) is synthesized in microglial cells and secreted in the human brain. Our results provide new insight into which microglial cells can promote the receptor for AGE-mediated neuronal cell death, eventually leading to neurodegenerative diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activated microglial cells produce and secrete AGE-albumin to induce RAGE expression in neurons and promote neuronal cell death, contributing to neurodegenerative disorders.
“Activated microglial cells produce and secrete AGE-albumin to induce RAGE expression in neurons and promote neuronal cell death, thereby contributing to neurodegenerative disorders4,108.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [108]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Regulation of cell death: the calcium–apoptosis link
Orrenius, S., Zhivotovsky, B., & Nicotera, P. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1150 · Cited by 2,990 · see citing works
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012 · see citing works
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
Schmidt, A. M., Yan, S. D., Yan, S. F., & Stern, D. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14002 · Cited by 1,256 · see citing works
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
Schmidt, A. M., Yan, S. D., Yan, S. F., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200114002 · Cited by 1,039 · see citing works
Hajnóczky, G., Csordás, G., Das, S., Garcı́a-Pérez, C., Saotome, M., Roy, S. S., & Yi, M. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.08.016 · Cited by 613 · see citing works
Edison, P., Archer, H. A., Gerhard, A., Hinz, R., Pavese, N., Turkheimer, F. E., Hammers, A., Tai, Y. F., Fox, N., Kennedy, A., et al. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.08.001 · Cited by 513 · see citing works
Kim, B.-J., Ryu, S.-W., & Song, B.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510644200 · Cited by 470 · see citing works
RAGE and Alzheimer's Disease: A Progression Factor for Amyloid-β-Induced Cellular Perturbation?
Yan, S. D., Bierhaus, A., Nawroth, P. P., & Stern, D. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1030 · Cited by 179 · see citing works
Ko, H. W., Park, K., Kim, H., Han, P., Kim, Y. U., Gwag, B. J., & Choi, E. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71041390.x · Cited by 102 · see citing works
Human Microglial Cells Synthesize Albumin in BrainPreprint
Ahn, S., Byun, K., Cho, K., Kim, J. Y., Yoo, J. S., Kim, D., Paek, S. H., Kim, S. U., Simpson, R. J., & Lee, B. (2008) · Nature Precedings · doi:10.1371/journal.pone.0002829 · Cited by 87 · see citing works
Self-citationTakeuchi, M., Sato, T., Takino, J.-I., Kobayashi, Y., Furuno, S., Kikuchi, S., & Yamagishi, S. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2006.12.017 · Cited by 42 · see citing works
Schumacher, U., Kretzschmar, H. A., & Pf�ller, U. (1994) · Acta Neuropathologica · doi:10.1007/bf00313612 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
Byun, K., Yoo, Y., Son, M., Lee, J., Jeong, G.-B., Park, Y. M., Salekdeh, G. H., & Lee, B. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.030 · Cited by 357 · see citing works
Self-citationDiabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview
Naik, L. C. P. (2014) · Journal of Pharmacovigilance · doi:10.4172/2329-6887.1000125 · Cited by 262 · see citing works
Oxidative Stress in Alzheimer’s Disease: Should We Keep Trying Antioxidant Therapies?
Ferreira, M. E. S., de Vasconcelos, A. S., Vilhena, T. D. C., da Silva, T. L., Barbosa, A. D. S., Gomes, A. R. Q., Dolabela, M. F., & Percário, S. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0157-y · Cited by 108 · see citing works
Hazrati, A., Malekpour, K., Soudi, S., & Hashemi, S. M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113943 · Cited by 73 · see citing works
Castellazzi, M., Morotti, A., Tamborino, C., Alessi, F., Pilotto, S., Baldi, E., Caniatti, L. M., Trentini, A., Casetta, I., Granieri, E., et al. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-0173-2 · Cited by 65 · see citing works
Wątroba, M., Grabowska, A. D., & Szukiewicz, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210069 · Cited by 60 · see citing works
Gonçalves, J., Leitão, R. A., Higuera‐Matas, A., Assis, M. A., Coria, S. M., Ribeiro, C., Ambrosio, E., & Silva, A. P. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.02.017 · Cited by 57 · see citing works
Namyen, J., Permpoonputtana, K., Nopparat, C., Tocharus, J., Tocharus, C., & Govitrapong, P. (2020) · Neurotoxicity Research · doi:10.1007/s12640-019-00156-1 · Cited by 50 · see citing works
CRISPR/Cas9 Edited sRAGE-MSCs Protect Neuronal Death in Parkinson’s Disease Model
Lee, J., Bayarsaikhan, D., Roshini, A., Park, H. J., Lim, B., Gwak, P., Jeong, G., Lee, J., Byun, K., & Lee, B. (2019) · International Journal of Stem Cells · doi:10.15283/ijsc18110 · Cited by 47 · see citing works
Self-citationChemically defined serum-free and xeno-free media for multiple cell lineages.
Usta, S. N., Scharer, C. D., Xu, J., Frey, T. K., & Nash, R. J. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2014.09.05 · Cited by 40 · see citing works
An, S. S. A., Lee, B., Byun, K., Bayarsaikhan, E., Bayarsaikhan, D., Lee, J., Son, M., Moon, J., Park, H., Roshini, A., et al. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s95077 · Cited by 42 · see citing works
Self-citationGlycated proteome: From reaction to intervention
Kulkarni, M. J., Korwar, A. M., Mary, S., Bhonsle, H. S., & Giri, A. P. (2012) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201200101 · Cited by 32 · see citing works
Chrysanthou, M., Estruch, I. M., Rietjens, I. M. C. M., Wichers, H. J., & Hoppenbrouwers, T. (2022) · Nutrients · doi:10.3390/nu14020363 · Cited by 29 · see citing works
Modulation of Neuronal Proteome Profile in Response to Japanese Encephalitis Virus Infection
Sengupta, N., Ghosh, S., Vasaikar, S. V., Gomes, J., & Basu, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090211 · Cited by 29 · see citing works
Kountouras, J., Boziki, M. K., Kazakos, E. I., Theotokis, P., Kesidou, E., Nella, M., Bakirtzis, C., Karafoulidou, E., Vardaka, E., Mouratidou, M. C., et al. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105724 · Cited by 23 · see citing works
Targeting Scavenger Receptors in Inflammatory Disorders and Oxidative Stress
Bayarsaikhan, G., Bayarsaikhan, D., Lee, J., & Lee, B. (2022) · Antioxidants · doi:10.3390/antiox11050936 · Cited by 20 · see citing works
Self-citationYu, S., Chen, X., Yang, T., Cheng, J., Liu, E., Jiang, L., Song, M., Shu, H., & Ma, Y. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0040 · Cited by 23 · see citing works
Chemokine CX3CL1 (Fractalkine) Signaling and Diabetic Encephalopathy
Wątroba, M., Grabowska, A. D., & Szukiewicz, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147527 · Cited by 13 · see citing works
Diabetes Mellitus: A Path to Amnesia, Personality, and Behavior Change
Ahmad, R., Chowdhury, K., Kumar, S., Irfan, M., Reddy, G. S., Akter, F., Jahan, D., & Haque, M. (2022) · Biology · doi:10.3390/biology11030382 · Cited by 14 · see citing works
Martati, E., Wang, H., Rietjens, I. M. C. M., & Zheng, L. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157772 · Cited by 8 · see citing works
Bayarsaikhan, D., Bayarsaikhan, G., Lee, J., & Lee, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415630 · Cited by 8 · see citing works
Self-citationKomorowska, J., Wątroba, M., Bednarzak, M., Grabowska, A. D., & Szukiewicz, D. (2023) · Medical Science Monitor · doi:10.12659/msm.941044 · Cited by 8 · see citing works
Coppo, L., Scheggi, S., DeMontis, G., Priora, R., Frosali, S., Margaritis, A., Summa, D., Giuseppe, D. D., Ulivelli, M., & Simplicio, P. D. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0269 · Cited by 5 · see citing works
[Use of sodium diclofenac in acute renal colic].
Tankó, A., & Tamás, G. (1996) · PubMed · Cited by 3 · see citing works
Szutowicz, A. (2015) · Diagnostyka Laboratoryjna · doi:10.5604/01.3001.0008.2261 · Cited by 3 · see citing works
- Authors
- Byun, K., Bayarsaikhan, E., Kim, D., Son, M., Hong, J., Jeong, G.-B., Paek, S. H., Won, M.-H., & Lee, B.
- Affiliations
- Gachon University (KR)
- Center for Genomics and Proteomics, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea.
- Seoul National University (KR)
- Kangwon National University (KR)
- Venue
- Anatomy & Cell Biology
- Publisher
- Korean Association of Anatomists
- Published
- 2012
- Volume
- 45
- Issue
- 1
- Pages
- 47
- ISSN
- 2093-3665 (ISSN-L)
- 2093-3673
- PMC
- PMC3328740
- OpenAlex
- W2097824168
- Cited by
- 26
- References
- 11
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2012: 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Anatomy & Cell Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Research Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- microglia, advanced glycation end products, glycated albumin, microglial activation, neurodegenerative diseases, neuronal cell death, Alzheimer's disease, Parkinson's disease, AGE receptor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
