Cited by 517Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

Open access
Edison, Paul, Archer, Hilary A., Gerhard, Alexander, Hinz, Rainer, Pavese, Nicola, Turkheimer, Federico E., Hammers, Alexander, Tai, Yen Fong +4 more·2008·Neurobiology of Disease

Abstract

[11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load. Here we studied in vivo the distributions of amyloid load and microglial activation in Alzheimer's disease (AD) and their relationship with cognitive status. Thirteen AD subjects had [11C](R)PK11195-PET and [11C]PIB-PET scans. Ten healthy controls had [11C](R)PK11195-PET and 14 controls had [11C]PIB-PET scans. Region-of-interest analysis of [11C](R)PK11195-PET detected significant 20-35% increases in microglial activation in frontal, temporal, parietal, occipital and cingulate cortices (p<0.05) of the AD subjects. [11C]PIB-PET revealed significant two-fold increases in amyloid load in these same cortical areas (p<0.0001) and SPM (statistical parametric mapping) analysis confirmed the localisation of these increases to association areas. MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage.

Integrity signals

Registry

Crossref · 10.1016/j.nbd.2008.08.001

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 55 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Edison, P., Archer, H. A., Gerhard, A., Hinz, R., Pavese, N., Turkheimer, F. E., Hammers, A., Tai, Y. F., Fox, N., Kennedy, A., Rossor, M., & Brooks, D. J.
Affiliations
  • Hammersmith Hospital (GB)
  • University of Manchester (GB)
Corresponding author
Edison, Paul
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2008-12
Volume
32
Issue
3
Pages
412-419
ISSN
0969-9961 (ISSN-L)
OpenAlex
W1993305977
Cited by
513
References
55
Citations by year
2026: 9 · 2025: 19 · 2024: 21 · 2023: 16 · 2022: 27 · 2021: 40 · 2020: 29 · 2019: 32 · 2018: 27 · 2017: 44 · 2016: 39 · 2015: 40 · 2014: 46 · 2013: 33 · 2012: 31
FWCI
12.97
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UCL Discovery (University College London) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
Medical Research Council
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, microglial activation, amyloid-beta, cognitive impairment, [11C](R)-PK11195, [11C]PIB, positron emission tomography, association cortex, Mini-Mental State Examination, neuroinflammation, neuronal injury
MeSH terms
Aged, Alzheimer Disease, Amyloid, Aniline Compounds, Carbon Radioisotopes, Cerebral Cortex, Cognition, Female, Humans, Isoquinolines, Magnetic Resonance Imaging, Male, Middle Aged, Thiazoles, Cluster Analysis, Microglia, Positron-Emission Tomography

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review