Composite nerve fibers in the hypogastric and pelvic splanchnic nerves: an immunohistochemical study using elderly cadavers
Open accessAbstract
To determine the proportion of nerve fibers in the hypogastric nerve (HGN) and pelvic splanchnic nerve (PSN), small tissue strips of the HGN and PSN from 12 donated elderly cadavers were examined histologically. Immunohistochemistry for neuronal nitric oxide synthase (NOS), vasoactive intestinal peptide (VIP), and tyrosine hydroxylase (TH) was performed. More than 70% of fibers per bundle in the HGN were positive for TH at the level of the sacral promontory. In addition, NOS- (negative) and/or VIP+ (positive) fibers were observed in small areas of each nerve bundle, although the proportion of each was usually less than 10%. In the PSN near the third sacral nerve root, the proportion of nerve fibers positive for NOS and/or VIP (or TH) was below 30%. In both the HGN and PSN, the number of VIP+ fibers was usually greater than that of NOS+ fibers, with frequent co-localization of NOS and VIP. More fibers in both nerves were positive for TH than for these other markers. In contrast to pelvic plexus branches, there were no differences in the proportions of NOS+ and VIP+ fibers between nerve bundles in each of the tissue strips. Thus, target-dependent sorting of nerve fibers was not apparent in the HGN at the level of the sacral promontory or in the PSN near the third sacral nerve root. The NOS+ and/or VIP+ fibers in the HGN were most likely ascending postganglionic fibers to the colon, while those in the PSN root may be preganglionic fibers from Onuf's nucleus.
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Peripheral nerve size and composition varies greatly; the major and minor diameters of the compound femoral nerve are about 10.5 mm and 2.3 mm, respectively, while pelvic splanchnic nerve bundles can be smaller than 0.05 mm or larger than 0.2 mm.
“for example, the major and minor diameters of the compound femoral nerve are about 10.5 mm and 2.3 mm, respectively. In contrast, the diameter of pelvic splanchnic nerve bundles can be smaller than 0.05 mm, or larger than 0.2 mm”
From Realizing flexible bioelectronic medicines for accessing the peripheral nerves – technology considerations (2018) · cites this paper as Jang et al. 2015
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- Authors
- Jang, H. S., Cho, K. H., Hieda, K., Kim, J. H., Murakami, G., Abe, S.-I., & Matsubara, A.
- Affiliations
- Wonkwang University Hospital (KR)
- Wonkwang University (KR)
- Hiroshima University (JP)
- Jeonbuk National University (KR)
- Division of Internal Medicine, Iwamizawa Kojin-kai Hospital, Iwamizawa, Japan.
- Department of Anatomy, Tokyo Dental College, Tokyo, Japan.
- Corresponding author
- Cho, Kwang Ho
- Venue
- Anatomy & Cell Biology
- Publisher
- Korean Association of Anatomists
- Published
- 2015
- Volume
- 48
- Issue
- 2
- Pages
- 114
- ISSN
- 2093-3665 (ISSN-L)
- 2093-3673
- PMC
- PMC4488639
- OpenAlex
- W1957698535
- Cited by
- 23
- References
- 36
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2016: 3
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Anatomy & Cell Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Keywords
- hypogastric nerve, pelvic splanchnic nerves, nerve fiber composition, neuronal nitric oxide synthase, vasoactive intestinal peptide, tyrosine hydroxylase, Onuf's nucleus, postganglionic fibers, preganglionic fibers, pelvic plexus, sacral promontory, elderly cadavers, autonomic nervous system
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