The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases
Open accessAbstract
Epithelial tight junctions (TJs) are the key structures regulating paracellular trafficking of macromolecules. The TJ is multi-protein complex that forms a selective permeable seal between adjacent epithelial cells and demarcates the boundary between apical and basolateral membrane domains. Disruption of the intestinal TJ barrier, followed by permeation of luminal noxious molecules, induces a perturbation of the mucosal immune system and inflammation, which can act as a trigger for the development of intestinal and systemic diseases. Inflammatory bowel disease (IBD) patients demonstrate increased intestinal paracellular permeability. Although it remains unclear whether barrier dysfunction precedes disease or results from active inflammation, increased intestinal TJ disruption is observed in IBD patients suggest that dysregulation of TJ barrier integrity may predispose or enhance IBD progression. Therefore, therapeutic target to restore the TJ barrier integrity may provide effective therapeutic and preventive approaches against IBD. This review discusses the molecular structure and regulation of intestinal TJs and the involvement of intestinal TJs in IBD pathogenesis.
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Cites
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
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An insight into gut microbiota and its functionalities
Adak, A., & Khan, M. R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2943-4 · Cited by 1,485
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Butyrate-producing human gut symbiont, Clostridium butyricum , and its role in health and disease
Stoeva, M. K., Garcia-So, J., Justice, N., Myers, J., Tyagi, S., Nemchek, M., McMurdie, P. J., Kolterman, O., & Eid, J. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1907272 · Cited by 518
Therapies from Fucoidan: An Update
Fitton, J., Stringer, D., & Karpiniec, S. (2015) · Marine Drugs · doi:10.3390/md13095920 · Cited by 418
Lee, B., Moon, K. M., & Kim, C. Y. (2018) · Journal of Immunology Research · doi:10.1155/2018/2645465 · Cited by 404
Metadata
- Authors
- Lee, S. H.
- Venue
- Intestinal Research
- Published
- 2015
- Volume
- 13
- Issue
- 1
- Pages
- 11
- ISSN
- 1598-9100 (ISSN-L)
- 2288-1956
- OpenAlex
- W2081864509
- Cited by
- 807
- References
- 5
- FWCI
- 32.89
- Type
- journal article
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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