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Cited by 15Maternal Mental Health During Pregnancy and PostpartumBioinformatics and Genomic NetworksTreatment of Major Depression

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Co-expression modules construction by WGCNA and identify potential hub genes and regulation pathways of postpartum depression

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Deng, Zhifang, Cai, Wei, Liu, Jue, Deng, Aiping, Yang, Yuan, Tu, Jie, Yuan, Cheng, Xiao, Han, Gao, Wenqi·2021·Frontiers in Bioscience-Landmark
DOI 10.52586/5006
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Abstract

Purpose : The purpose of our present study was to, for the first time, identify key genes associated with postpartum depression (PPD) and discovery the potential molecular mechanisms of this condition. Methods : First, microarray expression profiles GSE45603 dataset were acquired from the Gene Expression Omnibus (GEO) in National Center for Biotechnology Information (NCBI). The weighted gene co-expression network analysis (WGCNA) was performed to identify the top three modules from differentially expressed genes (DEGs). Furthermore, cross-validated differential gene expression analysis of the top three modules and DEGs was used to identify the hub genes. Gene set enrichment analysis (GSEA) was conducted to identify the potential functions of the hub genes. We conducted a Receiver Operator Characteristic (ROC) curve to verify the diagnostic efficiencies of the hub genes. Lastly, GSE44132 dataset was used to search the association between the methylation profiles of the hub genes and susceptibility to PPD. Results : Altogether, 8979 genes were identified as DEGs for WGCNA analysis. The turquoise, yellow, and green functional modules were the most significant modules related to PPD development after WGCNA analysis. The enrichment analysis results of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway demonstrated that hub genes in the three modules were mainly enriched in the neurotrophin signaling pathway, chemokine signaling pathway, Fcγ receptor-mediated phagocytosis,…

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Metadata

Authors
Deng, Z., Cai, W., Liu, J., Deng, A., Yang, Y., Tu, J., Yuan, C., Xiao, H., & Gao, W.
Affiliations
  • Central Hospital of Wuhan (CN)
  • Wuhan Children's Hospital (CN)
  • Wuhan University (CN)
  • Institute of Maternal and Child Health, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University and Technology, 430015 Wuhan, Hubei, China
ORCID
Venue
Frontiers in Bioscience-Landmark
Publisher
IMR Press
Published
2021-11-30
Volume
26
Issue
11
Pages
1019-1030
ISSN
  • 2768-6698 (ISSN-L)
  • 2768-6701
DOI
10.52586/5006
OpenAlex
W3216615230
Cited by
15
References
2
Citations by year
2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 1
FWCI
1.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Bioscience-Landmark (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
postpartum depression, hub genes, gene co-expression modules, differential gene expression, HNRNPA2B1, RPL13A, UBA52, DNA methylation, diagnostic biomarkers, neurotrophin signaling, chemokine signaling, MAPK signaling, KEGG pathway enrichment
MeSH terms
Female, Humans, Signal Transduction, Depression, Postpartum, Gene Expression Profiling, Gene Regulatory Networks

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