Epigenetics of the depressed brain: role of histone acetylation and methylation

Chromatin modifications and their function

Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works

The language of covalent histone modifications

Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679 · see citing works

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works

The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)

Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works

Epigenetic programming by maternal behavior

Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works

Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study

Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · cited 1× · see citing works

Epigenetic differences arise during the lifetime of monozygotic twins

Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602 · see citing works

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works

Genetic Epidemiology of Major Depression: Review and Meta-Analysis

Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431 · see citing works

Stress and Depression

Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979 · see citing works

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952 · see citing works

The molecular neurobiology of depression

Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works

The complex language of chromatin regulation during transcription

Berger, S. L. (2007) · Nature · doi:10.1038/nature05915 · Cited by 2,768 · see citing works

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

Allfrey, V. G., Faulkner, R. D., & Mirsky, A. E. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.51.5.786 · Cited by 2,649 · see citing works

Combinatorial patterns of histone acetylations and methylations in the human genome

Wang, Z., Zang, C., Rosenfeld, J. A., Schones, D. E., Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Peng, W., Zhang, M. Q., et al. (2008) · Nature Genetics · doi:10.1038/ng.154 · Cited by 2,331 · see citing works

Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions

Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works

The Strategy of the Genes

Waddington, C. H. (2014) · doi:10.4324/9781315765471 · Cited by 2,153 · see citing works

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works

THE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION

Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111 · cited 1× · see citing works

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments

Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works

The mesolimbic dopamine reward circuit in depression

Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works

Animal models of neuropsychiatric disorders

Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

Taunton, J., Hassig, C. A., & Schreiber, S. L. (1996) · Science · doi:10.1126/science.272.5260.408 · Cited by 1,829 · see citing works

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

Brownell, J. E., Zhou, J., Ranalli, T. A., Kobayashi, R., Edmondson, D. G., Dent, S., & Allis, C. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81063-6 · Cited by 1,636 · see citing works

Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS

Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605 · see citing works

Neuroimaging studies of mood disorders

Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,313 · see citing works

Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states

Gold, P. W., & Chrousos, G. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001032 · Cited by 1,274 · see citing works

The Strategy of the Genes: A Discussion of Some Aspects of Theoretical Biology

(1958) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1958.tb86500.x · Cited by 1,244 · see citing works

Dynamic DNA methylation programs persistent adverse effects of early-life stress

Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., & Spengler, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2436 · Cited by 1,162 · see citing works

Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants

Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Komatsu, N., Kumakiri, C., Nakazato, M., Watanabe, H., Shinoda, N., Okada, S.-I., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00181-1 · Cited by 1,151 · see citing works

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146 · see citing works

The subgenual anterior cingulate cortex in mood disorders

Drevets, W. C., Savitz, J., & Trimble, M. (2008) · CNS Spectrums · doi:10.1017/s1092852900013754 · Cited by 1,109 · see citing works

Epigenetic mechanisms of gene regulation

Russo, V. E. A., Martienssen, R. A., & Riggs, A. D. (1996) · Medical Entomology and Zoology · Cited by 1,088 · see citing works

Towards a Theoretical Biology

WADDINGTON, C. H. (1968) · Nature · doi:10.1038/218525a0 · Cited by 1,061 · see citing works

Stress-Induced Alterations in Prefrontal Cortical Dendritic Morphology Predict Selective Impairments in Perceptual Attentional Set-Shifting

Liston, C., Miller, M. M., Goldwater, D. S., Radley, J. J., Rocher, A. B., Hof, P. R., Morrison, J. H., & McEwen, B. S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1184-06.2006 · Cited by 968 · see citing works

Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus

Pencea, V., Bingaman, K. D., Wiegand, S. J., & Luskin, M. B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06706.2001 · Cited by 928 · see citing works

Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects

Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works

IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress

Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Alland, L., Muhle, R., Hou, H., Potes, J., Chin, L., Schreiber‐Agus, N., & DePinho, R. A. (1997) · Nature · doi:10.1038/387049a0 · Cited by 841 · see citing works

Attenuation of the Neural Response to Sad Faces in Major Depressionby Antidepressant Treatment: A Prospective, Event-Related Functional Magnetic Resonance ImagingStudy

Fu, C. H. Y., Williams, S. C. R., Cleare, A. J., Brammer, M. J., Walsh, N. D., Kim, J., Andrew, C. M., Pich, E. M., Williams, P. M., Reed, L. J., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.9.877 · Cited by 775 · see citing works

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762 · see citing works

Chronic stress alters dendritic morphology in rat medial prefrontal cortex

Cook, S. C., & Wellman, C. L. (2004) · Journal of Neurobiology · doi:10.1002/neu.20025 · Cited by 750 · see citing works

Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

Gao, L., Cueto, M. A., Asselbergs, F., & Atadja, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111871200 · Cited by 744 · see citing works

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

Maze, I., Covington, H. E., Dietz, D. M., LaPlant, Q., Renthal, W., Russo, S. J., Mechanic, M., Mouzon, E., Neve, R. L., Haggarty, S. J., et al. (2010) · Science · doi:10.1126/science.1179438 · Cited by 665 · see citing works

Neuroimaging studies of mood disorder effects on the brain

Sheline, Y. I. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00347-0 · Cited by 660 · see citing works

Antidepressant Actions of Histone Deacetylase Inhibitors

Covington, H. E., Maze, I., LaPlant, Q. C., Vialou, V. F., Ohnishi, Y. N., Berton, O., Fass, D. M., Renthal, W., Rush, A. J., Wu, E. Y., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1758-09.2009 · Cited by 624 · see citing works

The NPY system in stress, anxiety and depression

Heilig, M. A. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.05.002 · Cited by 617 · see citing works

Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior

Koo, J. W., Russo, S. J., Ferguson, D., Nestler, E. J., & Duman, R. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910658107 · Cited by 607 · see citing works

Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli

Renthal, W., Maze, I., Krishnan, V., Covington, H. E., Xiao, G., Kumar, A., Russo, S. J., Graham, A., Tsankova, N., Kippin, T. E., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.032 · Cited by 599 · see citing works

Genes, Genetics, and Epigenetics: A Correspondence

Wu, C.-T., & Morris, J. R. (2001) · Science · doi:10.1126/science.293.5532.1103 · Cited by 577 · see citing works

Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase III

Tse, C., Sera, T., Wolffe, A. P., & Hansen, J. C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4629 · Cited by 574 · see citing works

Preclinical models: status of basic research in depression

Nestler, E. J., Gould, E., & Manji, H. K. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01405-1 · Cited by 559 · see citing works

Chromatin disruption and modification

Wolffe, A. P., & Hayes, J. J. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.3.711 · Cited by 551 · see citing works

The Changing Concept of Epigenetics

Jablonka, E., & Lamb, M. J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04913.x · Cited by 545 · see citing works

Neuroimaging Abnormalities in the Amygdala in Mood Disorders

DREVETS, W. C. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07098.x · Cited by 544 · see citing works

Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse

Schroeder, F. A., Lin, C. L., Crusio, W. E., & Akbarian, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.036 · Cited by 541 · see citing works

Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain

Benraiss, A., Chmielnicki, E., Lerner, K., Roh, D., & Goldman, S. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06718.2001 · Cited by 540 · see citing works

Decoding the Epigenetic Language of Neuronal Plasticity

Borrelli, E., Nestler, E. J., Allis, C. D., & Sassone‐Corsi, P. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.012 · Cited by 529 · see citing works

Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors

Monteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502 · see citing works

Lack of Ventral Striatal Response to Positive Stimuli in Depressed Versus Normal Subjects

Epstein, J., Pan, H., Kocsis, J. H., Yang, Y., Butler, T., Chusid, J., Hochberg, H., Murrough, J., Strohmayer, E., Stern, E., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.10.1784 · Cited by 464 · see citing works

Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats

McGowan, P. O., Suderman, M., Sasaki, A., Huang, T. C. T., Hallett, M., Meaney, M. J., & Szyf, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014739 · Cited by 452 · see citing works

Histone Modifications at Gene Promoter Regions in Rat Hippocampus after Acute and Chronic Electroconvulsive Seizures

Tsankova, N. M., Kumar, A., & Nestler, E. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0589-04.2004 · Cited by 447 · see citing works

VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants

Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438 · see citing works

Histone H3 Lysine 4 Demethylation Is a Target of Nonselective Antidepressive Medications

Lee, M. G., Wynder, C., Schmidt, D. M., McCafferty, D. G., & Shiekhattar, R. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.05.004 · Cited by 438 · see citing works

Life Stress, Genes, and Depression: Multiple Pathways Lead to Increased Risk and New Opportunities for Intervention

Charney, D. S., & Manji, H. K. (2004) · Science s STKE · doi:10.1126/stke.2252004re5 · Cited by 426 · see citing works

Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines

Johnson, J. D., Campisi, J., Sharkey, C. M., Kennedy, S. L., Nickerson, M., Greenwood, B. N., & Fleshner, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.090 · Cited by 424 · see citing works

Orbitofrontal cortex function and structure in depression

DREVETS, W. C. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.029 · Cited by 417 · see citing works

Conserved Metabolic Regulatory Functions of Sirtuins

Schwer, B., & Verdin, E. M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.006 · Cited by 415 · see citing works

Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

Uchida, S., Hara, K., Kobayashi, A., Otsuki, K., Yamagata, H., Hobara, T., Suzuki, T., Miyata, N., & Watanabe, Y. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.023 · Cited by 398 · see citing works

CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

Wallace, D. L., Han, M.-H., Graham, D. L., Green, T. A., Vialou, V., Iñiguez, S. D., Cao, J.-L., Kirk, A., Chakravarty, S., Kumar, A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2257 · Cited by 342 · see citing works

Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery

Goldwater, D. S., Pavlides, C., Hunter, R. G., Bloss, E. B., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.053 · Cited by 333 · see citing works

Roles of H1 domains in determining higher order chromatin structure and H1 location

Allan, J., Mitchell, T. C., Harborne, N., et al. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90337-2 · Cited by 322 · see citing works

Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase

Zhang, W., Bone, J. R., Edmondson, D. G., Turner, B. M., & Dent, S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3155 · Cited by 322 · see citing works

The neuropathology of primary mood disorder

Harrison, P. J. (2002) · Brain · doi:10.1093/brain/awf149 · Cited by 321 · see citing works

Overview: a current perspective on twin studies of schizophrenia

Kendler, K. S. (1983) · American Journal of Psychiatry · doi:10.1176/ajp.140.11.1413 · Cited by 314 · see citing works

Poor replication of candidate genes for major depressive disorder using genome-wide association data

Bosker, F. J., Hartman, C. A., Nolte, I. M., Prins, B. P., Terpstra, P., Posthuma, D., van Veen, T., Willemsen, G., DeRijk, R. H., de Geus, E. J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.38 · Cited by 309 · see citing works

Regulation of hippocampal H3 histone methylation by acute and chronic stress

Hunter, R. G., McCarthy, K. J., Milne, T. A., Pfaff, D. W., & McEwen, B. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911143106 · Cited by 290 · see citing works

A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress

Covington, H. E., Maze, I., Sun, H., Bomze, H. M., DeMaio, K. D., Wu, E. Y., Dietz, D. M., Lobo, M. K., Ghose, S., Mouzon, E., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.007 · Cited by 289 · see citing works

Epigenetic Mechanisms of Depression and Antidepressant Action

Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134540 · Cited by 277 · see citing works

Maternal Care and DNA Methylation of a Glutamic Acid Decarboxylase 1 Promoter in Rat Hippocampus

Zhang, T., Hellstrom, I. C., Bagot, R. C., Wen, X., Diorio, J. C., & Meaney, M. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1039-10.2010 · Cited by 269 · see citing works

IκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity

Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M.-H., Ables, J. L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4763-10.2011 · Cited by 267 · see citing works

Long‐lasting depression‐like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury

Onishchenko, N. R., Karpova, N. N., Sabri, F., Ċastrén, E., & Ceccatelli, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05484.x · Cited by 263 · see citing works

Imipramine Treatment and Resiliency Exhibit Similar Chromatin Regulation in the Mouse Nucleus Accumbens in Depression Models

Wilkinson, M. B., Xiao, G., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T. J., & Nestler, E. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0932-09.2009 · Cited by 262 · see citing works

Brain-Derived Neurotrophic Factor MRNA Downregulation Produced by Social Isolation Is Blocked by Intrahippocampal Interleukin-1 Receptor Antagonist

Barrientos, R. M., Sprunger, D. B., Campeau, S., Higgins, E. A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00564-5 · Cited by 251 · see citing works

Nuclear Factor κB Signaling Regulates Neuronal Morphology and Cocaine Reward

Russo, S. J., Wilkinson, M. B., Mazei‐Robison, M. S., Dietz, D., Maze, I. S., Krishnan, V., Renthal, W. R., Graham, A., Birnbaum, S. G., Green, T. A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6173-08.2009 · Cited by 248 · see citing works

Bi-phasic change in BDNF gene expression following antidepressant drug treatment

Coppell, A., Pei, Q., & Zetterström, T. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00077-7 · Cited by 241 · see citing works

Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk‐1 protein expression

Heine, V. M., Zareno, J., Maslam, S., Joëls, M., & Lucassen, P. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03951.x · Cited by 225 · see citing works

NMDA receptor subunit composition controls synaptogenesis and synapse stabilization

Gambrill, A. C., & Barría, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012676108 · Cited by 221 · see citing works

Partial Normalization of Serum Brain-Derived Neurotrophic Factor in Remitted Patients after a Major Depressive Episode

Gervasoni, N., Aubry, J., Bondolfi, G., Osiek, C., Schwald, M., Bertschy, G., & Karege, F. (2005) · Neuropsychobiology · doi:10.1159/000085725 · Cited by 204 · see citing works

Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens

Maze, I. S., Feng, J., Wilkinson, M. B., Sun, H., Shen, L., & Nestler, E. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015483108 · Cited by 191 · see citing works

Altered gene expression of histone deacetylases in mood disorder patients

Hobara, T., Uchida, S., Otsuki, K., Matsubara, T., Funato, H., Matsuo, K., Suetsugi, M., & Watanabe, Y. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.08.015 · Cited by 185 · see citing works

Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test

Cryan, J. F., Page, M. E., & Lucki, I. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01628-4 · Cited by 184 · see citing works

Histone deacetylases—an important class of cellular regulators with a variety of functions

Hildmann, C., Riester, D., & Schwienhorst, A. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-0911-2 · Cited by 182 · see citing works

Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders

Dudley, K. J., Li, X., Kobor, M. S., Kippin, T. E., & Bredy, T. W. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.016 · Cited by 180 · see citing works

The forced swimming‐induced behavioural immobility response involves histone H3 phospho‐acetylation and c‐Fos induction in dentate gyrus granule neurons via activation of the N‐methyl‐ d ‐aspartate/extracellular signal‐regulated kinase/mitogen‐ and stress‐activated kinase signalling pathway

Chandramohan, Y., Droste, S. K., Arthur, J. S. C., & Reul, J. M. H. M. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06230.x · Cited by 180 · see citing works

Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition

Covington, H. E., Vialou, V. F., LaPlant, Q., Ohnishi, Y. N., & Nestler, E. J. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.022 · Cited by 178 · see citing works

Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor ( BDNF) gene and histone acetylation at its promoters in the rat hippocampus

Fuchikami, M., Morinobu, S., Kurata, A., Yamamoto, S., & Yamawaki, S. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008997 · Cited by 177 · see citing works

A Novel Role of the WNT-Dishevelled-GSK3  Signaling Cascade in the Mouse Nucleus Accumbens in a Social Defeat Model of Depression

Wilkinson, M. B., Dias, C., Magida, J., Mazei-Robison, M., Lobo, M., Kennedy, P., Dietz, D., Covington, H., Russo, S., Neve, R., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0039-11.2011 · Cited by 170 · see citing works

Dose-Related Effects of Chronic Antidepressants on Neuroprotective Proteins BDNF, Bcl-2 and Cu/Zn-SOD in Rat Hippocampus

Xu, H., Steven Richardson, J., & Li, X.-M. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300009 · Cited by 167 · see citing works

The Neuropeptide VGF Produces Antidepressant-Like Behavioral Effects and Enhances Proliferation in the Hippocampus

Thakker‐Varia, S., Krol, J. G., Nettleton, J., Bilimoria, P. M., Bangasser, D. A., Shors, T. J., Black, I. B., & Alder, J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1898-07.2007 · Cited by 166 · see citing works

Reduced Neuropeptide Y Concentrations in Suicide Brain

Widdowson, P. S., Ordway, G. A., & Halaris, A. E. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08877.x · Cited by 155 · see citing works

Chronic Stress Induces Sex-Specific Alterations in Methylation and Expression of Corticotropin-Releasing Factor Gene in the Rat

Sterrenburg, L., Gaszner, B., Boerrigter, J., Santbergen, L., Bramini, M., Elliott, E., Chen, A., Peeters, B. W. M. M., Roubos, E. W., & Kozicz, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028128 · Cited by 149 · see citing works

Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression

Karolewicz, B., Szebeni, K., Gilmore, T., Maciąg, D., Stockmeier, C. A., & Ordway, G. A. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008985 · Cited by 144 · see citing works

Long-lasting behavioural and molecular alterations induced by early postnatal fluoxetine exposure are restored by chronic fluoxetine treatment in adult mice

Karpova, N. N., Lindholm, J., Pruunsild, P., Timmusk, T., & Ċastrén, E. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.09.002 · Cited by 142 · see citing works

Persistent Interactions of Core Histone Tails with Nucleosomal DNA following Acetylation and Transcription Factor Binding

Mutskov, V. J., Gerber, D., Angelov, D., Ausió, J., Workman, J. L., & Dimitrov, S. I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6293 · Cited by 142 · see citing works

Stress risk factors and stress-related pathology: Neuroplasticity, epigenetics and endophenotypes

Radley, J. J., Kabbaj, M., Jacobson, L., Heydendael, W., Yehuda, R., & Herman, J. P. (2011) · Stress · doi:10.3109/10253890.2011.604751 · Cited by 142 · see citing works

Histone Regulation in the CNS: Basic Principles of Epigenetic Plasticity

Maze, I. S., Noh, K., & Allis, C. D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.124 · Cited by 136 · see citing works

Histone acetyltransferase complexes

Grant, P. A., & Berger, S. L. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1999.0298 · Cited by 136 · see citing works

Altered sirtuin deacetylase gene expression in patients with a mood disorder

Abe, N., Uchida, S., Otsuki, K., Hobara, T., Yamagata, H., Higuchi, F., Shibata, T., & Watanabe, Y. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.01.016 · Cited by 131 · see citing works

Chatting histone modifications in mammals

Izzo, A., & Schneider, R. (2010) · Briefings in Functional Genomics · doi:10.1093/bfgp/elq024 · Cited by 129 · see citing works

Psychological stress increases histone H3 phosphorylation in adult dentate gyrus granule neurons: involvement in a glucocorticoid receptor‐dependent behavioural response

Bilang‐Bleuel, A., Ulbricht, S., Chandramohan, Y., Carli, S. D., Droste, S. K., & Reul, J. M. H. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04358.x · Cited by 126 · see citing works

Reversible acetylation of chromatin: Implication in regulation of gene expression, disease and therapeutics

Selvi, R. B., & Kundu, T. K. (2009) · Biotechnology Journal · doi:10.1002/biot.200900032 · Cited by 120 · see citing works

Corticostriatal brain‐derived neurotrophic factor dysregulation in adult rats following prenatal stress

Fumagalli, F., Bedogni, F., Pérez, J., Racagni, G., & Riva, M. A. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03592.x · Cited by 119 · see citing works

Setdb1 Histone Methyltransferase Regulates Mood-Related Behaviors and Expression of the NMDA Receptor Subunit NR2B

Jiang, Y., Jakovcevski, M., Bharadwaj, R., Connor, C., Schroeder, F. A., Lin, C. L., Straubhaar, J., Martin, G., & Akbarian, S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1314-10.2010 · Cited by 118 · see citing works

Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus

Yamawaki, Y., Fuchikami, M., Morinobu, S., Segawa, M., Matsumoto, T., & Yamawaki, S. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.585663 · Cited by 117 · see citing works

Effects of the histone deacetylase inhibitor sodium butyrate in models of depression and anxiety

Gundersen, B. B., & Blendy, J. A. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.04.008 · Cited by 112 · see citing works

Balancing histone methylation activities in psychiatric disorders

Peter, C. J., & Akbarian, S. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.02.003 · Cited by 110 · see citing works

Countervailing Modulation of I h by Neuropeptide Y and Corticotrophin-Releasing Factor in Basolateral Amygdala As a Possible Mechanism for Their Effects on Stress-Related Behaviors

Giesbrecht, C. J., Mackay, J. P., Silveira, H., Urban, J. H., & Colmers, W. F. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2306-10.2010 · Cited by 108 · see citing works

Individual differences in the effect of social defeat on anhedonia and histone acetylation in the rat hippocampus

Hollis, F., Duclot, F., Gunjan, A., & Kabbaj, M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.09.005 · Cited by 107 · see citing works

Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression

Iga, J.-I., Ueno, S.-I., Yamauchi, K., Numata, S., Kinouchi, S., Tayoshi-Shibuya, S., Song, H., & Ohmori, T. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.014 · Cited by 105 · see citing works

Histone acetylation: truth of consequences?This paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

Choi, J. K., & Howe, L. J. (2009) · Biochemistry and Cell Biology · doi:10.1139/o08-112 · Cited by 104 · see citing works

Histone methylation and decreased expression of TrkB.T1 in orbital frontal cortex of suicide completers

Ernst, C., Chen, E. S., & Turecki, G. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.35 · Cited by 98 · see citing works

Epigenetic mechanisms in stress-related memory formation

Reul, J. M. H. M., & Chandramohan, Y. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.016 · Cited by 92 · see citing works

Chromatin regulation in drug addiction and depression

Renthal, W. R., & Nestler, E. J. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/wrenthal · Cited by 91 · see citing works

Effect of Acetylation on the Binding of N-Terminal Peptides of Histone H4 to DNA

Cary, P. D., Crane‐Robinson, C., Bradbury, E. M., & Dixon, G. H. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb06847.x · Cited by 88 · see citing works

Regulation of histone acetylation in the hippocampus of chronically stressed rats: a potential role of sirtuins

Ferland‐Beckham, C., & Schrader, L. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.077 · Cited by 86 · see citing works

When the Serotonin Transporter Gene Meets Adversity: The Contribution of Animal Models to Understanding Epigenetic Mechanisms in Affective Disorders and Resilience

Lesch, K.-P. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2010_109 · Cited by 86 · see citing works

Major depression and the environment: a psychiatric genetic perspective

Kendler, K. (1998) · Pharmacopsychiatry · doi:10.1055/s-2007-979287 · Cited by 85 · see citing works

Role of histone acetylation in cell physiology and diseases: An update

Khan, S. N., & Khan, A. U. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.06.020 · Cited by 77 · see citing works

Histone acetylation in chicken erythrocytes. Rates of acetylation and evidence that histones in both active and potentially active chromatin are rapidly modified

Zhang, D., & Nelson, D. A. (1988) · Biochemical Journal · doi:10.1042/bj2500233 · Cited by 73 · see citing works

Neuropeptide Y Y1 and Y2 Receptor mRNA Expression in the Prefrontal Cortex of Psychiatric Subjects Relationship of Y2 Subtype to Suicidal Behavior

Caberlotto, L. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00231-1 · Cited by 67 · see citing works

Effects of histone acetylation on chromatin topology in vivo.

Lutter, L. C., Judis, L. M., & Paretti, R. F. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5004 · Cited by 62 · see citing works

Effects of histone acetylation on chromatin topology in vivo

Lutter, L. C., Judis, L., & Paretti, R. F. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5004-5014.1992 · Cited by 58 · see citing works

Enhanced Sensitivity of the MRL/MpJ Mouse to the Neuroplastic and Behavioral Effects of Chronic Antidepressant Treatments

Balu, D. T., Hodes, G. E., Anderson, B. T., & Lucki, I. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.234 · Cited by 57 · see citing works

Antidepressant-like effects of sodium butyrate in combination with estrogen in rat forced swimming test: Involvement of 5-HT1A receptors

Zhu, H., Huang, Q., Xu, H., Niu, L., & Zhou, J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.08.039 · Cited by 53 · see citing works

Histone acetylation in chicken erythrocytes. Rates of deacetylation in immature and mature red blood cells

Zhang, D. E., & Nelson, D. A. (1988) · Biochemical Journal · doi:10.1042/bj2500241 · Cited by 50 · see citing works

Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains

Benton, C. S., Miller, B. H., Skwerer, S., Suzuki, O., Schultz, L. E., Cameron, M. D., Marron, J. S., Pletcher, M. T., & Wiltshire, T. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2574-z · Cited by 48 · see citing works

DNA Methylation: Basic Mechanisms

Doerfler, W., & Böhm, P. (2006) · Springer eBooks · doi:10.1007/3-540-31390-7 · Cited by 37 · see citing works

Neurodevelopment and Mood Stabilizers

Harwood, A. J. (2003) · Current Molecular Medicine · doi:10.2174/1566524033479672 · Cited by 33 · see citing works

Anna-Monika-Prize paper. Major depression and the environment : a psychiatric perspective

Kendler, K. S. (1998) · Medical Entomology and Zoology · Cited by 29 · see citing works

Potential Antidepressant Properties of Subchronic GABA Transaminase Inhibitors in the Forced Swimming Test in Mice

Semba, J., Kuroda, Y., & Takahashi, R. (2008) · Neuropsychobiology · doi:10.1159/000118569 · Cited by 18 · see citing works

Major depressive disorder

Otte, C., Gold, S. M., Penninx, B. W., Pariante, C. M., Etkin, A., Fava, M., Mohr, D. C., & Schatzberg, A. F. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.65 · Cited by 2,269 · see citing works

The brain reward circuitry in mood disorders

Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750 · see citing works

Biological and psychosocial predictors of postpartum depression: systematic review and call for integration

Yim, I. S., Tanner Stapleton, L. R., Guardino, C. M., Hahn-Holbrook, J., & Dunkel Schetter, C. (2015) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-101414-020426 · Cited by 749 · see citing works

Pathogenesis of depression: Insights from human and rodent studies

Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

Zhang, J.-C., Yao, W., & Hashimoto, K. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160119094646 · Cited by 538 · see citing works

Stress, epigenetics and depression: A systematic review

Park, C., Rosenblat, J. D., Brietzke, E., Pan, Z., Lee, Y., Cao, B., Zuckerman, H., Kalantarova, A., & McIntyre, R. S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.010 · Cited by 465 · see citing works

HPA Axis in the Pathomechanism of depression and schizophrenia: new therapeutic strategies based on its participation

Mikulska, J., Juszczyk, G., Gawrońska-Grzywacz, M., & Herbet, M. (2021) · Brain Sciences · doi:10.3390/brainsci11101298 · Cited by 450 · see citing works

Animal models of major depression and their clinical implications

Czéh, B., Fuchs, E., Wiborg, O., & Simon, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.04.004 · Cited by 375 · see citing works

Psychological processing in chronic pain: a neural systems approach

Simons, L. E., Elman, I., & Borsook, D. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.006 · Cited by 359 · see citing works

The impact of environmental factors in severe psychiatric disorders

Schmitt, A., Malchow, B., Hasan, A., & Falkai, P. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00019 · Cited by 322 · see citing works

Role of BDNF in the Pathophysiology and Treatment of Depression: Activity-Dependent Effects Distinguish Rapid-Acting Antidepressants

Duman, R. S., Deyama, S., & Fogaça, M. V. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14630 · Cited by 321 · see citing works

Metabolic disturbances connecting obesity and depression

Hryhorczuk, C., Sharma, S., & Fulton, S. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00177 · Cited by 322 · see citing works

The role of DNA methylation in stress-related psychiatric disorders

Klengel, T., Pape, J., Binder, E. B., & Mehta, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.013 · Cited by 309 · see citing works

Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

Zhang, J.-C., Wu, J., Fujita, Y., Yao, W., Ren, Q., Yang, C., Li, S.-X., Shirayama, Y., & Hashimoto, K. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu077 · Cited by 289 · see citing works

The depressed brain: an evolutionary systems theory

Badcock, P. B., Davey, C. G., Whittle, S., Allen, N. B., & Friston, K. J. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.01.005 · Cited by 190 · see citing works

Epigenetic mechanisms of major depression: Targeting neuronal plasticity

Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works

The serotonin-BDNF duo: developmental implications for the vulnerability to psychopathology

Homberg, J. R., Molteni, R., Calabrese, F., & Riva, M. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.012 · Cited by 177 · see citing works

Epigenetic signaling in psychiatric disorders: stress and depression

Bagot, R. C., Labonté, B., Peña, C. J., & Nestler, E. J. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/rbagot · Cited by 171 · see citing works

Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist

Shirayama, Y., Yang, C., Zhang, J.-C., Ren, Q., Yao, W., & Hashimoto, K. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.09.002 · Cited by 137 · see citing works

Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus

Zheng, Y., Fan, W., Zhang, X., & Dong, E. (2016) · Epigenetics · doi:10.1080/15592294.2016.1146850 · Cited by 111 · see citing works

Potential roles of zinc in the pathophysiology and treatment of major depressive disorder

Swardfager, W., Herrmann, N., McIntyre, R. S., Mazereeuw, G., Goldberger, K., Cha, D. S., Schwartz, Y., & Lanctôt, K. L. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.018 · Cited by 116 · see citing works

Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress

Hamilton, P. J., Burek, D. J., Lombroso, S. I., Neve, R. L., Robison, A. J., Nestler, E. J., & Heller, E. A. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.88 · Cited by 113 · see citing works

Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress

Nasca, C., Bigio, B., Zelli, D., de Angelis, P., Lau, T., Okamoto, M., Soya, H., Ni, J., Brichta, L., Greengard, P., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.020 · Cited by 113 · see citing works

Role of the Brain's Reward Circuitry in Depression

Nestler, E. J. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.07.003 · Cited by 108 · see citing works

Evidence for epigenetic regulation of pro-inflammatory cytokines, interleukin-12 and interferon gamma, in peripheral blood mononuclear cells from PTSD patients

Bam, M., Yang, X., Zhou, J., Ginsberg, J. P., Leyden, Q., Nagarkatti, P. S., & Nagarkatti, M. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9643-8 · Cited by 103 · see citing works

A model for streamlining psychotherapy in the RDoC era: the example of ‘Engage’

Alexopoulos, G. S., & Arean, P. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.150 · Cited by 95 · see citing works

Antidepressant action of HDAC inhibition in the prefrontal cortex

Covington, H. E., Maze, I., Vialou, V., & Nestler, E. J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.030 · Cited by 97 · see citing works

ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior

Sun, H., Damez-Werno, D. M., Scobie, K. N., Shao, N.-Y., Dias, C., Rabkin, J., Koo, J. W., Korb, E., Bagot, R. C., Ahn, F. H., et al. (2015) · Nature Medicine · doi:10.1038/nm.3939 · Cited by 91 · see citing works

Altered miRNA expression network in locus coeruleus of depressed suicide subjects

Roy, B., Wang, Q., Palkovits, M., Faludi, G., & Dwivedi, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-04300-9 · Cited by 86 · see citing works

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: possible relevance for treatment-resistant depression

Meylan, E. M., Halfon, O., Magistretti, P. J., & Cardinaux, J.-R. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.012 · Cited by 87 · see citing works

Progress in Epigenetics of Depression

Peña, C. J., & Nestler, E. J. (2018) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2017.12.011 · Cited by 84 · see citing works

Neuroinflammatory basis of depression: learning from experimental models

Afridi, R., & Suk, K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.691067 · Cited by 82 · see citing works

Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides

Zhou, Y., Lutz, P.-E., Wang, Y. C., Ragoussis, J., & Turecki, G. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0267-7 · Cited by 77 · see citing works

Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy

Jorgensen, A., Krogh, J., Miskowiak, K., Bolwig, T. G., Kessing, L. V., Fink-Jensen, A., Nordentoft, M., Henriksen, T., Weimann, A., Poulsen, H. E., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.02.011 · Cited by 74 · see citing works

Effects of DNA methylation inhibitors and conventional antidepressants on mice behaviour and brain DNA methylation levels

Sales, A. J., & Joca, S. R. L. (2016) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.40 · Cited by 62 · see citing works

Early life trauma, depression and the glucocorticoid receptor gene—An epigenetic perspective

Smart, C., Strathdee, G., Watson, S., Murgatroyd, C., & McAllister-Williams, R. H. (2015) · Psychological Medicine · doi:10.1017/s0033291715001555 · Cited by 61 · see citing works

Developmental exposure to 50 parts-per-billion arsenic influences histone modifications and associated epigenetic machinery in a region- and sex-specific manner in the adult mouse brain

Tyler, C. R., Hafez, A. K., Solomon, E. R., & Allan, A. M. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.07.013 · Cited by 60 · see citing works

Histone acetylation and expression of mono-aminergic transmitters synthetases involved in CUS-induced depressive rats

Liu, D., Qiu, H.-M., Fei, H.-Z., Hu, X.-Y., Xia, H.-J., Wang, L.-J., Qin, L.-J., Jiang, X.-H., & Zhou, Q.-X. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370213513987 · Cited by 49 · see citing works

The importance of epigenetics in diagnostics and treatment of major depressive disorder

Czarny, P., Białek, K., Ziółkowska, S., Strycharz, J., Barszczewska, G., & Sliwinski, T. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11030167 · Cited by 37 · see citing works

The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review

Persaud, N. S., & Cates, H. M. (2023) · eneuro · doi:10.1523/eneuro.0109-21.2021 · Cited by 41 · see citing works

Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson’s disease.

Bortolozzi, A., Manashirov, S., Chen, A., & Artigas, F. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107873 · Cited by 37 · see citing works

H3K9 acetylation of Tph2 involved in depression-like behavior in Male, but not female, juvenile offspring rat induced by prenatal stress

Dang, S., Lu, Y., Su, Q., Lin, T., Zhang, X., Zhang, H., Zhang, J., Zhang, L., Zhu, Z., & Li, H. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.043 · Cited by 30 · see citing works

Moving pharmacoepigenetics tools for depression toward clinical use

Hack, L. M., Fries, G. R., Eyre, H. A., Bousman, C. A., Singh, A. B., Quevedo, J., John, V. P., Baune, B. T., & Dunlop, B. W. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.02.009 · Cited by 33 · see citing works

A MIR4646 associated methylation locus is hypomethylated in adolescent depression

Boström, A. E., Ciuculete, D.-M., Attwood, M., Krattinger, R., Nikontovic, L., Titova, O. E., Kullak-Ublick, G. A., Mwinyi, J., & Schiöth, H. B. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.05.017 · Cited by 33 · see citing works

On the role of epigenetic modifications of HPA axis in posttraumatic stress disorder and resilience

Khan, Z., Messiri, N. E., Iqbal, E., Hassan, H., Tanweer, M. S., Sadia, S. R., Taj, M., Zaidi, U., Yusuf, K., Syed, N. I., et al. (2025) · Journal of Neurophysiology · doi:10.1152/jn.00345.2024 · Cited by 32 · see citing works

Update on the neurodevelopmental theory of depression: is there any 'unconscious code'?

Gałecka, M., Bliźniewska-Kowalska, K., Maes, M., Su, K.-P., & Gałecki, P. (2021) · Pharmacological Reports · doi:10.1007/s43440-020-00202-2 · Cited by 27 · see citing works

SAHA improves depressive symptoms, cognitive impairment and oxidative stress: rise of a new antidepressant class

Ershadi, A. S. B., Amini-Khoei, H., Hosseini, M.-J., & Dehpour, A. R. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03263-8 · Cited by 25 · see citing works

The molecular basis of depression: implications of sex-related differences in epigenetic regulation

Kawatake-Kuno, A., Murai, T., & Uchida, S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.708004 · Cited by 23 · see citing works

Understanding the Neuroepigenetic Constituents of Suicide Brain

Roy, B., & Dwivedi, Y. (2018) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2018.01.007 · Cited by 17 · see citing works

Prenatal stress induces long-term behavioral sex-dependent changes in rats offspring: the role of the HPA axis and epigenetics

Possamai-Della, T., Cararo, J. H., Aguiar-Geraldo, J. M., Peper-Nascimento, J., Zugno, A. I., Fries, G. R., Quevedo, J., & Valvassori, S. S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03348-1 · Cited by 16 · see citing works

The interaction of P11 methylation and early-life stress impacts the antidepressant response in patients with major depressive disorder

Wang, T., Li, L., Yue, Y., Liu, X., Chen, S., Shen, T., Xu, Z., & Yuan, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.06.042 · Cited by 10 · see citing works

Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook

Lv, L.-Z., Wang, Z.-D., Ren, J.-J., Li, L.-H., Liu, X.-B., Li, J.-L., Zhu, H., Jiang, B., Han, Y.-P., Zhou, X.-M., et al. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2025.1722453 · Cited by 7 · see citing works

Histone H10: A maintainer of the differentiated cell state?

van Helden, P. D. (1985) · International Journal of Biochemistry · doi:10.1016/0020-711x(85)90214-9 · Cited by 5 · see citing works

[Protein composition of fragmented rat liver chromatin during postnatal ontogenesis].

Klimenko, A. I., Malyshev, A. B., & Shevtsova, M. I. (1978) · PubMed

Changing the Selectivity of p300 by Acetyl-CoA Modulation of Histone Acetylation

Henry, R. A., Kuo, Y., Bhattacharjee, V., Yen, T. J., & Andrews, A. J. (2014) · ACS Chemical Biology · doi:10.1021/cb500726b · Cited by 78 · see citing works

Histone acetylation in chicken erythrocytes. Estimation of the percentage of sites actively modified

Zhang, D., & Nelson, D. A. (1986) · Biochemical Journal · doi:10.1042/bj2400857 · Cited by 23 · see citing works

Critical review of non‐histone human substrates of metal‐dependent lysine deacetylases

Toro, T. B., & Watt, T. J. (2020) · The FASEB Journal · doi:10.1096/fj.202001301rr · Cited by 23 · see citing works