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Cited by 38Barrier Structure and Function StudiesCerebrospinal fluid and hydrocephalusNeuroinflammation and Neurodegeneration Mechanisms

The blood cerebrospinal fluid barrier orchestrates immunosurveillance, immunoprotection, and immunopathology in the central nervous system

Open access
Ayub, Maria, Jin, Hee Kyung, Bae, Jae-sung·2021·BMB Reports
DOI 10.5483/bmbrep.2021.54.4.205PMC PMC8093941
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Abstract

Once characterized as an immune privileged area, recent scientific advances have demonstrated that the central nervous system (CNS) is both immunologically active and a specialized site. The anatomical and cellular features of the brain barriers, the glia limitans, and other superficial coverings of the CNS endow the brain with specificity for immune cell entry and other macro- and micro-elements to the brain. Cellular trafficking via barriers comprised of tightly junctioned non-fenestrated endothelium or tightly regulated fenestrated epithelium results in different phenotypic and cellular changes in the brain, that is, inflammatory versus regulatory changes. Based on emerging evidence, we described the unique ability of the blood cerebrospinal fluid barrier (BCSFB) to recruit, skew, and suppress immune cells. Additionally, we sum up the current knowledge on both cellular and molecular mechanisms governed by the choroid plexus and the cerebrospinal fluid at the BCSFB for immunosurveillance, immunoprotection, and immunopathology. [BMB Reports 2021; 54(4): 196-202].

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  • BCSFB disruption impairs its selectivity, leading to increased infiltration of cytokines and leukocytes into the CSF, which then activate glial cells in the CNS.

    “BCSFB disruption impaired the selectivity of it, leading to increased infiltration of cytokines and leukocytes into the CSF which then activated glial cells in the CNS.”

    From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [145]

    The MS subsection (page unavailable) says loss of a tight-junction protein essential to BCSFB function enhances leukocyte infiltration into the CSF and brain parenchyma. The paper does not establish the rest of the proposed chain: increased cytokine infiltration into the CSF followed by activation of CNS glial cells. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • BCSFB disruption in AD is induced by proinflammatory cytokines or matrix metalloproteinase (MMP) expressed by choroid plexus epithelial cells.

    “Numerous studies have revealed AD associated BCSFB disruption induced by proinflammatory cytokines or matrix metalloproteinase (MMP) expressed by CP epithelial cells.”

    From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [145]

    The “Aging and AD” section reports BCSFB changes and disrupted choroid plexus–CSF function in AD. It does not attribute that disruption to proinflammatory cytokines or to matrix metalloproteinases expressed by choroid plexus epithelial cells; its AD discussion instead describes altered transthyretin transport and nitric-oxide signaling. No page numbers are available in our copy. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

  • Role of neuroinflammation in neurodegeneration development

    Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668 · see citing works

    “BCSFB disruption impaired the selectivity of it, leading to increased infiltration of cytokines and leukocytes into the CSF which then activated glial cells in the CNS.144,145 BCSFB acts as a gateway for inflammationresolving leukocyte entry into the CSF during immune responses through the constitutively expressed adh…”
    BackgroundInfluential

Authors
Ayub, M., Jin, H. K., & Bae, J.-S.
Affiliations
Kyungpook National University (KR)
Corresponding author
Ayub, Maria
ORCID
Venue
BMB Reports
Publisher
Korean Society for Biochemistry and Molecular Biology - BMB Reports
Published
2021-04-30
Volume
54
Issue
4
Pages
196-202
ISSN
  • 1976-6696 (ISSN-L)
  • 1976-670X
DOI
10.5483/bmbrep.2021.54.4.205
PMC
PMC8093941
OpenAlex
W3110772232
Cited by
38
References
4
Citations by year
2026: 7 · 2025: 11 · 2024: 4 · 2023: 11 · 2022: 5
FWCI
2.00
Type
journal article
Language
en
Open access
Licence
Locations
  • BMB Reports (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
Ministry of Science and ICT, South Korea (2017R1A4A1015652, 2020R1A2C3006875, 2020R1A2C3006734)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
blood-CSF barrier, central nervous system immunity, immune surveillance, immunoprotection, immunopathology, choroid plexus, cerebrospinal fluid, immune cell trafficking, blood-brain barrier, immune privilege, neuroinflammation
MeSH terms
Blood-Brain Barrier, Central Nervous System, Humans

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