The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence
Abstract
Hedgehog signaling is required for maintaining the integrity of the blood-brain barrier.
Integrity signals
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Astrocytes influence blood-brain barrier integrity, and transporters at astrocytic endfeet are relevant to the blood-brain barrier because astrocytic endfeet surround brain vessels.
“While astrocytes also influence BBB integrity and transporters at astrocytic endfeet are relevant to the BBB since astrocytic endfeet surround brain vessels (13, 667, 682), currently the transcriptome or proteome specifically enriched only in astrocytic endfeet has not been examined.”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [13]
During postnatal development, astrocytes can release Shh to promote brain vascular integrity by acting on EC Patched-1 receptors.
“During postnatal development, astrocytes can release Shh to promote the brain vascular integrity by acting on EC Patched-1 receptors9.”
From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [9]
At postnatal stages, astrocyte-secreted Shh promotes vascular integrity of the brain by activating Hedgehog signaling in ECs through the receptor Patched-1.
“At postnatal stages, astrocyte-secreted Shh further promotes vascular integrity of the brain by activating Hedgehog signaling in ECs through the receptor Patched-19.”
From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [9]
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- Authors
- Alvarez, J. I., Dodelet-Devillers, A., Kebir, H., Ifergan, I., Fabre, P. J., Terouz, S., Sabbagh, M., Wosik, K., Bourbonnière, L., Bernard, M., van Horssen, J., de Vries, H. E., Charron, F., & Prat, A.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- Neuroimmunology Unit, Center of Excellence in Neuromics, Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Faculty of Medicine, Université de Montréal, Montréal, Quebec, H2L 4M1, Canada.
- Montreal Clinical Research Institute (CA)
- Department of Molecular Cell Biology and Immunology, VU Medical Center, 1007 MB Amsterdam, Netherlands.
- Corresponding author
- Alvarez, Jorge Ivan
- Dodelet-Devillers, Aurore
- Prat, Alexandre
- ORCID
- Venue
- Science
- Published
- 2011-12-23
- Volume
- 334
- Issue
- 6063
- Pages
- 1727-1731
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013517841
- Cited by
- 845
- References
- 3
- Citations by year
- 2026: 34 · 2025: 69 · 2024: 66 · 2023: 60 · 2022: 67 · 2021: 89 · 2020: 80 · 2019: 54 · 2018: 51 · 2017: 55 · 2016: 33 · 2015: 75 · 2014: 36 · 2013: 45 · 2012: 28
- FWCI
- 19.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Canadian Institutes of Health Research (MOP81880, MOP74700)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- Hedgehog signaling, blood-brain barrier, Sonic hedgehog, endothelial cells, perivascular astrocytes, leukocyte adhesion, leukocyte migration, pro-inflammatory mediators, multiple sclerosis, CNS homeostasis
- MeSH terms
- Animals, Astrocytes, Blood-Brain Barrier, Brain, Cell Adhesion, Cell Movement, Cells, Cultured, Encephalomyelitis, Autoimmune, Experimental, Female, Humans, Mice, Inbred C57BL, Multiple Sclerosis, Permeability, Veratrum Alkaloids, Signal Transduction, CD4-Positive T-Lymphocytes, Electric Impedance, Inflammation Mediators, Chemokines, Endothelial Cells, Mice, Hedgehog Proteins
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