The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
Open accessAbstract
a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause.
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Cites
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A unique view on male infertility around the globe
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Role of reactive oxygen species in the pathophysiology of human reproduction
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Self-citationOxidative stress and male infertility—a clinical perspective
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Self-citationThe International Glossary on Infertility and Fertility Care, 2017
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Effect of Oxidative Stress on Male Reproduction
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Self-citationEuropean Association of Urology Guidelines on Male Infertility: The 2012 Update
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Cited by
Li, K.-P., Yang, X.-S., & Wu, T. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.810242 · Cited by 79
Cicek, O. S. Y., Kaya, G., Alyuruk, B., Doger, E., Girisen, T., & Filiz, S. (2021) · International braz j urol · doi:10.1590/s1677-5538.ibju.2019.0751 · Cited by 17
Bibi, R., Jahan, S., Afsar, T., Almajwal, A., Hammadeh, M. E., Amor, H., Abusharha, A., & Razak, S. (2023) · Biomedicines · doi:10.3390/biomedicines11020467 · Cited by 15
Metadata
- Authors
- Agarwal, A., Parekh, N., Panner Selvam, M. K., Henkel, R., Shah, R., Homa, S. T., Ramasamy, R., Ko, E., Tremellen, K., Esteves, S., Majzoub, A., Alvarez, J. G., Gardner, D. K., Jayasena, C. N., Ramsay, J. W., Cho, C.-L., Saleh, R., Sakkas, D., Hotaling, J. M., Lundy, S. D., Vij, S., Marmar, J., Gosalvez, J., Sabanegh, E., Park, H. J., Zini, A., Kavoussi, P., Micic, S., Smith, R., Busetto, G. M., Bakırcıoğlu, M. E., Haidl, G., Balercia, G., Puchalt, N. G., Ben-Khalifa, M., Tadros, N., Kirkman-Browne, J., Moskovtsev, S., Huang, X., Borges, E., Franken, D., Bar-Chama, N., Morimoto, Y., Tomita, K., Srini, V. S., Ombelet, W., Baldi, E., Muratori, M., Yumura, Y., La Vignera, S., Kosgi, R., Martinez, M. P., Evenson, D. P., Zylbersztejn, D. S., Roque, M., Cocuzza, M., Vieira, M., Ben-Meir, A., Orvieto, R., Levitas, E., Wiser, A., Arafa, M., Malhotra, V., Parekattil, S. J., Elbardisi, H., Carvalho, L., Dada, R., Sifer, C., Talwar, P., Gudeloglu, A., Mahmoud, A. M. A., Terras, K., Yazbeck, C., Nebojsa, B., Durairajanayagam, D., Mounir, A., Kahn, L. G., Baskaran, S., Pai, R. D., Paoli, D., Leisegang, K., Moein, M.-R., Malik, S., Yaman, O., Samanta, L., Bayane, F., Jindal, S. K., Kendirci, M., Altay, B., Perovic, D., & Harlev, A.
- Venue
- The World Journal of Men's Health
- Publisher
- XMLink
- Published
- 2019
- Volume
- 37
- Issue
- 3
- Pages
- 296
- ISSN
- 2287-4208 (ISSN-L)
- 2287-4690
- OpenAlex
- W2945116772
- Cited by
- 474
- References
- 136
- FWCI
- 43.79
- Type
- journal article
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility. https://app.cochat.ai/papers/10.5534/wjmh.190055
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- Agarwal, A., Parekh, N., Panner Selvam, M. K., Henkel, R., Shah, R., Homa, S. T., Ramasamy, R., Ko, E., Tremellen, K., Esteves, S., Majzoub, A., Alvarez, J. G., Gardner, D. K., Jayasena, C. N., Ramsay, J. W., Cho, C.-L., Saleh, R., Sakkas, D., Hotaling, J. M., . . . Harlev, A. (2019). Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility. The World Journal of Men's Health. https://doi.org/10.5534/wjmh.190055
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.