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Cited by 17Sperm and Testicular FunctionAntioxidant Activity and Oxidative StressReproductive Health and Technologies

The association of seminal oxidation reduction potential with sperm parameters in patients with unexplained and male factor ınfertility

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Cicek, Ozge Senem Yucel, Kaya, Gozde, Alyuruk, Begum, Doger, Emek, Girisen, Tugba, Filiz, Serdar·2021·International braz j urol
DOI 10.1590/s1677-5538.ibju.2019.0751PMC PMC7712687
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Abstract

PURPOSE: Understanding the effects of high oxidation reduction potential (ORP) levels on sperm parameters will help to identify patients with unexplained and male factor infertility who may have seminal oxidative stress and determine if ORP testing is needed. This study aimed to evaluate the association between seminal ORP and conventional sperm parameters. MATERIALS AND METHODS: A total of 58 patients who provided a semen sample for simultaneous evaluation of sperm parameters and ORP between January and September 2019 were enrolled in this retrospective study. To identify normal and high ORP levels, a static ORP (sORP) cut-off value of 1.36mV/106sperm/mL was used. Sperm parameters were compared between infertile men with normal sORP (control group, n=23) and high sORP values (study group, n=35). RESULTS: Men with sORP values >1.36mV/106sperm/mL had significantly lower total sperm count (TSC) (p <0.001), sperm concentration (p <0.001) and total motile sperm count (TMSC) (p <0.001). In addition, progressive motility (p=0.04) and fast forward progressive motility (p <0.001) were significantly lower in the study group. A negative correlation was found between sORP and TSC (r=-0.820, p <0.001), sperm concentration (r=-0.822, p <0.001), TMSC (r=-0.808, p <0.001) and progressive motility (r=-0.378, p=0.004). Non-progressive motility positively correlated with sORP (r=0.344, p=0.010). CONCLUSIONS: This study has shown that TSC, sperm concentration, progressive motility and TMSC are associated with seminal oxidative stress, indicated by a sORP cut-off of 1.36mV/106sperm/mL. Presence of oligozoospermia, reduced progressive motilty or low TMSC in sperm analysis should raise the suspicion of oxidative stress and warrants seminal ROS testing.

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • OS negatively affects all sperm functions, including sperm DNA integrity, and thereby the fertilization process and reproductive outcomes.

    “Consequently, OS negatively affects all sperm functions, including sperm DNA integrity [47,48], and thereby the fertilization process and reproductive outcomes [49,50,51,52,53,54,55].”

    From The Sixth Edition of the WHO Manual for Human Semen Analysis: A Critical Review and SWOT Analysis (2021) · cites this paper as [47]

    The Introduction says excessive ROS can cause sperm DNA damage and dysfunction, supporting the claim's general point. But the Results report no correlation between oxidative-stress measure sORP and total motility or immotility, so the source does not support the unqualified assertion that oxidative stress negatively affects *all* sperm functions. The later clause about fertilization and reproductive outcomes is attached to different citations in the citing sentence. (LLM, conf=0.86)

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1 of the 25 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [13]Arafa M Agarwal A Al Said S Majzoub A Sharma R Bjugstad KB Elbardisi H. Semen quality and infertility status can be identified through measures of oxidation-reduction potential Andrologia 2018 50 50 28771782 13. Arafa M, Agarwal A, Al Said S, Majzoub A, Sharma R, Bjugstad KB, et al. Elbardisi H. Semen quality and infertility status can be identified through measures of oxidation-reduction potential. Andrologia. 2018; 50. 28771782

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Authors
Cicek, O. S. Y., Kaya, G., Alyuruk, B., Doger, E., Girisen, T., & Filiz, S.
Affiliations
  • Kocaeli Üniversitesi (TR)
  • Kocaeli University, Turkey
  • Kocaeli University, Turkey; Kocaeli University, Turkey
Corresponding author
Cicek, Ozge Senem Yucel
ORCID
Venue
International braz j urol
Publisher
FapUNIFESP (SciELO)
Published
2021-02
Volume
47
Issue
1
Pages
112-119
ISSN
  • 1677-5538 (ISSN-L)
  • 1677-6119
DOI
10.1590/s1677-5538.ibju.2019.0751
PMC
PMC7712687
OpenAlex
W3092044727
Cited by
17
References
25
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2022: 6 · 2021: 2 · 2020: 1
FWCI
1.98
Type
journal article
Language
en
Open access
Licence
Locations
  • International braz j urol (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Kocaeli Üniversitesi - AVESİS (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords
redox potential, seminal oxidative stress, male infertility, unexplained infertility, semen parameters, sperm motility, total sperm count, sperm concentration, oligozoospermia, reactive oxygen species
MeSH terms
Humans, Infertility, Male, Male, Oxidation-Reduction, Retrospective Studies, Semen, Sperm Count, Sperm Motility, Spermatozoa

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