Low Cardiac Output Syndrome after Cardiac Surgery: A Life-Threatening Condition from the Perspective of Pediatric Intensivists
Open accessAbstract
Low cardiac output syndrome is a clinical picture insourcing from insufficient oxygen sup- ply to tissues so as to meet the metabolic demand, myocardial dysfunction, and cardiovas- cular insufficiency. Low cardiac output syndrome is seen in nearly 25% of pediatric patients who underwent corrective or palliative surgery due to congenital heart defects. It is a clinical condition occurring typically 6-18 hours after surgery in pediatric patients undergoing cardiac surgery and causes organ failure, prolonged hospital and intensive care hospitalization time, increased resource utilization, and mortality. The identification and correct management of this serious complication in the early period is very important. However, there is no clear con- sensus or consensus report on the follow-up of this patient group and the definition of low cardiac output syndrome. Clinicians generally produced low cardiac output syndrome defini- tions according to their own approach. In this review, we aim to draw attention to low cardiac output syndrome and hope to summarize the pathophysiology, etiology, clinical definition, and treatment options of low cardiac output syndrome as a life-threatening condition in pediatric intensive care unit.
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NIRS was proved efficient in identifying low cardiac output syndrome, leading to its routine use after cardiopulmonary bypass.
“NIRS was proved efficient in identifying low cardiac output syndrome (LCOS), leading to its routine use after cardiopulmonary bypass [64].”
From Trends and Challenges in Noninvasive Hemodynamic Monitoring of Neonates Following Cardiac Surgery: A Narrative Review (2025) · cites this paper as [64]
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Sobieraj, M., Urbanowicz, T. K., Wiśniewska, A. O. –., Gładki, M. M., Michalak, M., Filipiak, K. J., Węclewska, A., Bartkowska‐Śniatkowska, A., Tykarski, A., Bobkowski, W., et al. (2024) · Advances in Medical Sciences · doi:10.1016/j.advms.2024.03.004 · Cited by 2 · see citing works
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Ali, S. G., Alatroush, H. H., Omar, E. E., Kotb, M. A., & Wafa, M. A. (2026) · The Egyptian Journal of Critical Care Medicine · doi:10.1007/s44349-026-00041-9
Huang, Y., Hu, J., Lan, X., Guo, D., Chen, J., Yu, J., Zhong, Y., Tian, C., Li, W., & Liu, Z. (2026) · BMC Cardiovascular Disorders · doi:10.1186/s12872-026-05911-9
“LCOS is one of the most serious postoperative complications in VHD patients, which can prolong the hospital stay, increase costs, and even lead to death [4, 5].”
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Shahannaz, D. C., & Sugiura, T. (2026) · Complications · doi:10.3390/complications3030013
“…oxidative stress, restoration of mitochondrial ATP stores depleted during aortic cross-clamping, and re-establishment of intracellular calcium homeostasis through sarcoplasmic reticulum re-sequestration—processes essential for normalization of excitation–contraction coupling [60,72].”
Khddam, A., Turkmani, L. T., & Hajeer, M. Y. (2026) · Cureus · doi:10.7759/cureus.115537
- Authors
- Department of Pediatric Intensive Care, M. T. A. R. H., Aslan, N., Yildizdas, D., & Department of Pediatric Intensive Care, C. U. F. O. M.
- ORCID
- Aslan, Nagehan
- Venue
- Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology
- Publisher
- Turkish Society of Cardiology
- Published
- 2022-06-07
- Volume
- 50
- Issue
- 4
- Pages
- 284-292
- ISSN
- 1308-4488 (ISSN-L)
- OpenAlex
- W4281719591
- Cited by
- 20
- References
- 0
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 6 · 2023: 3
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Keywords
- low cardiac output syndrome, pediatric cardiac surgery, congenital heart disease, postoperative complications, cardiac dysfunction, organ failure, clinical definition, pathophysiology, treatment options, pediatric intensive care
- MeSH terms
- Cardiac Output, Cardiac Output, Low, Child, Heart Defects, Congenital, Cardiac Surgical Procedures, Humans, Postoperative Complications, Intensive Care Units, Pediatric
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